Searle grant funds proteomics initiative
...p retain them. "We are very grateful to the Searle family and The Chicago Community Trust for their generous gift," said Lawrence B. Dumas, provost of Northwestern University. "Their support of the Chicago Biomedical Consortium will help make Chicago a leader in and destination for biomedical research." "Th...UCSD medical researchers discover molecular pathway that turns a juvenile heart into an adult heart
...ular and Molecular Medicine. ASF/SF2 are part of a family of proteins that function in a vital cellular process called alternative splicing the mechanism through which a single gene can generate several kinds of proteins by selecting different combinations of the same set of amino acid building blocks. Al...Scientists decipher genome of fungus that can cause life-threatening infections
...kely involved in capsule biosynthesis, including a family containing 7 members of the capsule associated (CAP64) gene. Researchers compared two closely related genomes of C. neoformans that differ markedly in their virulence properties. The results indicate that the differences likely involve other ...Albatross study provides new information vital to their conservation
Albatrosses are the world's most threatened family of birds. New research offers the first hope of identifying migration and feeding patterns to reduce their unnecessary slaughter by long-line fisheries. The study is reported in the journal Science , and outlines, for the first time, the year-round ...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...the chemical mixture. The research is focused on a family of genes known as P53, which helps to regulate the cell cycle. They have also moved their studies to a new model system: the zebrafish, a vertebrate with more similarities to humans. Reinisch's work on BCE is funded by a STAR grant from the ...Genetic testing for Parkinson's disease on the horizon
...e LRRK2 gene in 482 Parkinson's patients without a family history of the disease. The investigators found that the mutation was present in 8 patients; implicating the mutation in sporadic as well as inherited forms of the disease. William Nichols (Cincinnati Children's Hospital Medical Centre, Cincinnati, U...Individualized medicine emerging from gene-environment studies
...ividual. He says, "When doctors knew you and your family and your work and home environment, they were able to treat and prescribe for you based on their awareness of those unique characteristics. Advances in genetics can help return to a more individualized approach to medicine."...New genetic mutation linked to Parkinson's disease
...es on Parkinson's disease patients without a known family history of the disease. Dr. Wood found the same LRRK2 gene mutation in eight of 482 study participants. The Bonifati study identified the same LRRK2 gene mutation as the Cincinnati Children's study. Bonifati found the mutation in four of 61 families ...Scientists detect probable genetic cause of some Parkinson's disease cases
... 5 percent of Parkinson's disease in people with a family history of the disorder and may account for 1 to 2... percent of cases in individuals who do not have a family history of the disease. The researchers found a mutation in one copy of the gene can lead to the dis...Study identifies the most common genetic cause of Parkinson's disease
...ed on Parkinson's disease patients without a known family history of the disease. Dr. Wood found the same LRRK2 gene mutation in eight of 482 individuals in the study. The Bonifati study identified the same LRRK2 gene mutation as the Cincinnati Children's study. Bonifati found the mutation in four of 61 fam...New cancer gene identified by Memorial Sloan-Kettering scientists
...ikely to be aggressive. "Pokemon is a member of a family of proteins that are known to be transcription factors and are mutated in human cancer," said Takahiro Maeda, MD, PhD, a postdoctoral research fellow in Dr. Pandolfi's laboratory who was the paper's first author. "It is likely that the protein plays ...Scientists find common roots for thousands of plant compounds
...s called terpenoids - the largest and most diverse family of natural products - come from a single plant pathway, located inside the same part of a cell where photosynthesis occurs. Terpenoids are made from compounds called precursor molecules, which are a kind of molecular raw material. Just as a potter ca...Research may speed development of new oral drugs for fertility treatments
...up is now concentrating on the action of the large family of G-protein-coupled-receptors -- including those for the glycoprotein hormones -- that regulate a vast range of cellular processes....Key molecule in plant photo-protection identified
...olecules of zeaxanthin, a member of the carotenoid family of pigment molecules, carry away the excess energy. This study was led by Graham Fleming, director of Berkeley Lab's Physical Biosciences Division and a chemistry professor with UC Berkeley, and Kris Niyogi, who also holds joint appointments with B...Why do some people get bitten by mosquitoes more than others?
...t that when you go on holiday some members of your family always seem to get bitten more than others? Researchers supported by the Biotechnology and Biological Sciences Research Council (BBSRC) think they may have found the answer and their work could lead to new types of insect repellent. James Logan, a re...The Cochrane Library Newsletter, 2005, Issue 1
...ne contracts the disease, doctors try to treat all family members and close contacts with antibiotics to eradicate the bacteria and prevent the disease spreading. In addition, antibiotics can be given periodically to 'at risk' groups of people to wipe out the background population of bacteria. Rifampi...Plant protein mimics hormone that mitigates diabetes and obesity
...otein, called osmotin, belongs to a large, diverse family of proteins that defend plants from fungal pathogens. Bressan and his colleagues report in the current issue (Friday, Jan. 21) of Molecular Cell that a protein in mammal muscle cells called a receptor, which normally binds to the hormone adiponectin,...By age 6, children of overweight mothers are also prone to obesity
... environmental influence apparent in the study was family income; lower income was associated with higher body weight, similar to the pattern found in adults. The researchers found no genetic influence for the fathers' weight, possibly because the number of children studied was not large enough. "This resea...Study provides insights on why some prostate cancer becomes resistant to hormone withdrawl therapy
...duced by prostate cells that binds to androgens, a family of chemically related hormones that includes testosterone. Although the binding of androgens to the receptor is important for healthy prostate development, the hormones may, under some conditions, stimulate the prostate-tumor cells to divide. For tha...Protein tyrosine phosphatases to be topic of ASBMB-Merck Award lecture
...osine residues in proteins. All members of the PTP family contain a highly conserved motif in their active s...ratory has recently identified 107 members of this family in the human genome. The PTP superfamily enzymes participate in a wide variety of cellular processes...