JCI Table of Contents -- July 2, 2007
... repairs cardiac cell rupture Kevin Campell and fellow University of Iowa researchers have shown that a protein known as dysferlin plays a critical role in repairing the plasma membranes of cardiac muscle cells that are torn as a result of strain-induced injury. Inadequate cell membrane repair may be inv...Europe struggles to meet the challenges posed by PGD patients travelling abroad
...at Newcastle University and is a visiting research fellow at Durham University Law School, UK, is a co-author of the report and he focused on the legal, ethical and regulatory aspects of the research in his presentation to the ESHRE conference. Reproductive and genetic technologies are regulated in a wide...New approach to pulmonary hypertension shows promise
...diagnosis," said Sebastien Bonnet, a post-doctoral fellow in the U of A Department of Medicine and first author of the paper. However, the U of A researchers believe they've made a breakthrough in their discovery of the role that nuclear-factor-of-activated-T-lymphocytes (NFAT) play in the cause of the di...Satellite images reveal link between urban growth and changing rainfall patterns
...sor of geological and environmental sciences and a fellow at the Woods Institute for the Environment at Stanford University. ''The exciting thing is really for the first time, using a time series of satellite images, we can monitor Earth in a way that we haven't been able to,'' Seto said. ''It's not just ...Time-lapse recordings reveal why IVF embryos are more likely to develop into twins
...ding into twins. Dianna Payne, a visiting research fellow at the Mio Fertility Clinic, Yonago, Japan, told the 23rd annual meeting of the European Society of Human Reproduction and Embryology today (Monday 2 July) that about three pairs of twins per thousand deliveries occurred as a result of natural concep...Support for chromosomal theory of cancer found in cancers' development of drug resistance
...chromosomes. Duesberg and UC Berkeley postdoctoral fellow Ruhong Li showed that the karyotype of drug-resistant cancer cells differs significantly from the karyotype of drug-sensitive cells from which they grew. Clinicians have found, for example, that the gene expression profile of a breast cancer cell c...Gene variant increases risk for alcoholism following childhood abuse
...ins first author Francesca Ducci, M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic region (MAOA-LPR) -- of the MAOA gene. Two such MAOA-LPR variants occur most frequently and result in high or lo...MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
.... Hayashi, a former Picower Institute postdoctoral fellow currently at Merck Research Laboratories in Boston. The study identifies a key enzyme-a chemical reaction-inducing protein-as a possible target for an FXS drug. The enzyme, called p21-activated kinase, or PAK, affects the number, size and shape of ...Omega-3 fatty acids protect eyes against retinopathy, study finds
...ient Kip M. Connor, Ph.D., a postdoctoral research fellow at Childrens Hospital Boston. Given this, it is remarkable that with only a two percent change in dietary omega-3 intake, we observed an approximate 40-50 percent decrease in retinopathy severity. Our findings represent new evidence suggesting the...Weill Cornell team identifies potential new cancer drug target
...plains lead researcher Dr. Miao Lu, a postdoctoral fellow of biochemistry at Weill Cornell. In their experiments, the researchers used a variety of cutting-edge techniques, including X-ray crystallography, to track changes in the structure and activity of XIAP and the molecules it interacts with in cells.......A in the mouse genome, says Sen Wu, a postdoctoral fellow in human genetics at the University of Utah and HHMI. The best way to know the function of the genetic blueprint is by removing part of the DNA and seeing what goes wrong. We have found a way to do this job on a large scale that is simple and practic...Genetic defect links respiratory disease and congenital heart disease
...or of pediatrics, andDr. Marcus P. Kennedy, then a fellow in pulmonary and critical care medicine at UNC-Chapel Hill, to examine the connection between PCD and heterotaxy. Out of 337 patients with PCD, 21 (6. 3 percent) had heterotaxy. The researchers performed genetic testing on 12 patients with heterota...Dartmouth professor makes case for ethically universal stem cell lines
...research and also respect the sensitivities of our fellow citizens. Its not impossible to do both, says Green, the Eunice and Julian Cohen Professor for the Study of Ethics and Human Values, and the faculty director of the Dartmouth Ethics Institute. In addition to resolving current debates, he argues, thes...Pesticides choke pathway for nature to produce nitrogen for crops
...h and National Research Service Award postdoctoral fellow under Joe Thornton, a professor of biology who focuses on phylogenomics and nuclear receptor genes. Fox and colleagues began detailing their findings in the journal Nature (2001) and Environmental Health Perspectives (2004), testing more than 50 ch...Organic Food Miles take toll on environment
...osts, said researcher Vicki Burtt. Burtt and her fellow researchers compared the cost of food miles between organic and conventionally grown produce, and found that there was little difference in the cost to the environment. Food miles are defined as the distance that food travels from the field to the ...Genetic 'fellow traveler' discovered in Alzheimer's
...ecause of their subtle effects. To identify such fellow traveler genes, the research team performed comparative analyses of the entire genomes of 1,411 people who were either Alzheimers-affected carriers of APOE epsilon 4 or unaffected controls. They searched for tiny genetic variations, called single-nuc...Reprogrammed fibroblasts identical to embryonic stem cells
... student Ruth Foreman; and Manching Ku, a research fellow from Bradley Bernsteins lab at Massachusetts General Hospital. Konrad Hochedlinger, formerly of the Jaenisch lab and now heading his own laboratory at Massachusetts General Hospital, also contributed. Using artificial viruses called vectors, the ...Cancer drug enhances long-term memory
...and other psychiatric disorders, said Wood, also a fellow of the UCI Center for the Neurobiology of Learning and Memory. Wood and his colleagues placed mice in a chamber and gave them mild electric shocks, similar to static electricity shocks that humans can get when they walk across a rug and touch a doo...Mule deer moms rescue other fawns
...ngle, who conducted the research as a postdoctoral fellow in biological sciences at the University of Alberta and in psychology at the University of Lethbridge. "It was surprising just how indiscriminate mule deer females were. For example, the females that weren't even mothers also ran to the speakers t......ologist Monica Diez-Silva, now an MIT postdoctoral fellow and an author of the PNAS paper. Shortly after this meeting, Suresh started a formal collaboration known as GEM4 (Global Enterprise for MicroMechanics and Molecular Medicine), which brings together researchers from MIT, Institut Pasteur, the Nation...