Genomics-based vaccine could prevent deadly cattle disease
Rockville, MD--Every year, East Coast fever destroys the small farmer's dream of escaping pove...oteins that could form the basis for an East Coast fever subunit vaccine. Based on combined bioinformatics analyses and lab tests, these proteins appear to p...Biologists visualize protein interaction that may initiate viral infection
...us insect-borne diseases such as West Nile, yellow fever and St. Louis encephalitis. These diseases, however, use different biological mechanisms than dengue to infect host cells. Dengue is prevalent in Southeast Asia, Central America and South America. Mosquitoes transmit the virus to people, setting in m...Patterns in genome organization may partially explain how microbial cells work
...135 bacteria ranging from those that cause typhoid fever and various other human infections to organisms that enrich the nitrogen content of soil. In addition, 16 more primitive microorganisms, including one that thrives in boiling hot springs, also exhibit patterns in their genomes that are highly nonrand...Typhoid fever led to the fall of Athens
...from an ancient Greek burial pit points to typhoid fever as the disease responsible for this devastating ep...fever. The results of this study point to typhoid fever as the probable cause of the Plague of Athens. Typhoid fever is transmitted by contaminated food or ...Gene-specific Ebola therapies protect non-human primates from lethal disease
...viral replication. Ebola virus causes hemorrhagic fever with case fatality rates as high as 80 percent in humans. The virus, which is infectious by aerosol (although more commonly spread through blood and bodily fluids of infected patients), is of concern both as a global health threat and a potential age...Infectious agent thwarts typical defense mechanisms; Sheds light on immune system function
...s present, and increased levels of IL-1B trigger a fever one of the mechanisms the body uses to rid itself of some pathogens. IL-1B levels typically increase as the immune system begins to fight an infection, but not to the degree that the researchers saw in this study. "The response was greater here than...How Rickettsial pathogens break into cells
...able Rickettsia conorii, the Mediterranean spotted fever pathogen, to enter cells. Understanding how this b...lated pathogens, including Rocky Mountain spotted fever and typhus. Pascale Cossart, an HHMI international research scholar at the Pasteur Institute in Pari...X-rays good predictor of survival in avian flu patients
...ally represents pus and infection in patients with fever and a cough," said Nagmi Qureshi, F.R.C.R., a fellow of thoracic radiology at the University of Oxford in England. "We also discovered that the severity of these findings turned out to be a good predictor of patient mortality." The investigators stud...Scientists evaluate impact of preemptive malaria treatment for infants
... and the overall severity of infections, including fever attacks, by 50 percent. The researchers have now expanded their project to cover 300 children in an effort to determine the most effective dosage. "Our key message is that the supplements of vitamin A and zinc confer a solid measure of protection a...Gene variants predict heart muscle damage after cardiac surgery
...he bloodstream as a natural reaction to infection, fever or other injury. ICAM-1 allows the white cells to attach to the inner lining of the blood vessels where they inflict damage. LBP regulates the body's response to bacteria normally living in the gastrointestinal tract that can release endotoxins into ...UV measurement tool aids defense against microbes in tap water
...clude acute diarrhea, abdominal pain, vomiting and fever that can last up to two weeks in healthy adults, but may be chronic or fatal in those with a compromised immune system. In 1993, a massive outbreak of Crypto transmitted through the public water supply infected an estimated 400,000 people in Milwauke...Tulane receives multi-million grant for hemorrhagic fever research
...will develop modern diagnostic tests for the Lassa fever virus and other hemorrhagic fevers. "This project...currently available. Hemorrhagic fevers begin with fever and muscle aches, then may worsen until the patient becomes very ill with severe bleeding (hemorrhag...CU virologist finds contagious equine flu in dogs
...said Dubovi, noting that symptoms can include high fever and a respiratory infection that lasts a few weeks, although 1 to 5 percent die from related hemorrhagic pneumonia. From January to May 2005, outbreaks occurred at 20 racetracks in 10 states (Florida, Texas, Arkansas, Arizona, West Virginia, Kansas, ...Sept/Oct 2005 Annals of Family Medicine tip sheet
...ting for primary HIV infection among patients with fever or other viral symptoms may be a good expenditure ...g a hypothetical cohort of 3 million patients with fever and other viral symptoms, regardless of HIV risk factors, using the p24 antigen EIA test would ident...Duke researchers uncover genetic link to stroke after heart surgery
...he bloodstream as a natural reaction to infection, fever or other injury, while IL-6 is a protein that regulates the intensity of the immune response. Of the patients enrolled in the study, 36 percent had the polymorphism pair in question 3.09 percent of those patients suffered a stroke, while only 0.95 p...Infectious disease expert warns of spread of Rocky Mountain spotted fever
...ck-borne infection known as Rocky Mountain spotted fever warns that the first widespread outbreak of the ba...tibiotics if caught early. "Rocky Mountain spotted fever is a dangerous and potentially fatal disease, unlike its more widespread cousin, Lyme disease, which...Mechanism proposed for link between RU-486 and fatal infections
...e they often lack the usual warning signs, such as fever and tenderness on examination. In 2004, the labeling of mifepristone was amended to include a black box warning about bacterial infections, sepsis, and death that may occur after use. A citizen petition for withdrawal of mifepristone from the US mar...Certolizumab pegol demonstrates positive results in two Phase III Crohn's disease trials
...ominal pain, and at times loss of appetite/weight, fever or rectal bleeding . Unfortunately there is no single test to diagnose Crohn' TM s disease and because it can often imitate other gastroenterological conditions, patients may experience a lengthy diagnosis process. Although Crohn' TM s disease affe...Prevalence of infection in a population can shape parasite virulence
...ompetition, Bedhomme et al. worked with the yellow fever mosquito Aedes aegypti and its natural enemy, the single-celled parasite Vavraia culicis . They divided recently hatched mosquito larvae into groups of 60 larvae, and exposed half of the groups to the parasite. Larvae were then placed two by two i...Elevated temperature enhances success of viral cancer therapy
...n clinical trials. Now, new research suggests that fever might be a useful weapon in the fight as well. The...cate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. This study indicates that induction of a he...