Tag: "fibroblasts" at biology news
Pain reliever may help treat life-threatening childhood disease
... of tested compounds. Researchers used human fibroblasts
taken from patients with Type I SMA, the most seve... can't extract spinal neurons from humans, and the fibroblasts
gave us a pretty good idea of indoprofen's affect on human cells," Burghes said. SMN protei...
Cigarette smoke a culprit in poor healing and increased scarring
...e effects of cigarette smoke on the phase in which fibroblasts
proliferate and migrate to create healing tissue, ...ng normal development of wound healing tissue, the fibroblasts
at the site of the wound produce proteins that form a matrix into which fibroblasts
and endothelial ...
Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
...s condition arises when heart cells called cardiac fibroblasts
are activated. These cells secrete collagen, a pro...tural support for the heart. Overactive cardiac fibroblasts
cause fibrosis of the heart tissue, which then loses its ability to efficiently pump blood, said Jos...
Olfactory receptor cells may provide clues to psychiatric disease
...revious studies have used non-nerve cells, such as fibroblasts
or red blood cells, to examine how cells function in patients with bipolar disorder. But since this is a psychiatric disorder, we need to understand what's going on in nerve cells." Olfactory receptor neurons (ORNs), located in a small patch of epit...
Study of genomic DNA leads to new advances in cancer diagnostics
... epithelium and breast carcinoma cells, and normal fibroblasts
and fibrosarcoma cells) and diagnostic biopsy samples. Will these methods help clinicians in diagnosing cancer? Because the investigators utilized several practical methods in their study, potential exists for future diagnostic applications. The ...
Keeping cancer in check
...tigators looked at noncancerous mouse cells called fibroblasts
to see how normal cells work and what they do physiologically when faced with an environmental challenge: in this case, low glucose levels, explains Jones. When the enzyme called AMP-activated protein kinase (AMPK) is turned on, it prevents cells...
MIT tissue engineers implant viable, vascularized 3D muscles
...independently self-organize into vessel tubes; and fibroblasts
that are the precursors for the smooth muscle cell...mooth muscle cells," she says. "The differentiated fibroblasts
expressed the angiogenic growth factor, VEGF, which further stimulated vessel growth." The construct...
New study finds how cells with damaged DNA alert the immune system
...chers put cultures of ovarian epithelial cells and fibroblasts
from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic material -- the DNA damage ...
Researchers identify gene's role in suppressing longevity
...of defects," said Alt. "And when we grew embryonic fibroblasts
from those mice in culture, we observed that, unli...is that we have only shown this in mouse embryonic fibroblasts
so far. It needs to be demonstrated in other differentiated cells and in stem cells," he said. "A se...
JCI table of contents November, 2005
...he authors use normal human skin keratinocytes and fibroblasts
on a three-dimensional matrix to support the complete process of T cell development from bone marrow-derived precursor cells. This work provides evidence that skin and bone marrow biopsies can provide the starting material for generation of a new, ...
Study sheds light on signaling mechanism in stem cells, cancer
...two studies, one involving cultured epithelial and fibroblasts
cells expressing Smoothened, another involving a mouse embryo. In both cases, one set of cells was exposed to Hedgehog signals. Another set was exposed to cyclopamine, a drug that blocks Smoothened's function. In the cells exposed to the Hedgehog sig...
JCI table of contents: December 15, 2005
...uki Mizutani and colleagues have now shown that in fibroblasts
deficient in ATM it is failure of the early G2/M phase checkpoint to detect these etoposide-induced chromosomal abnormalities and arrest cell cycle progression that allows structural abnormalities in chromosome 11 to be retained during cell division....
Cancer support cells may evolve, fuel tumor growth, study shows
...ng tissue cells. Next, the researchers showed that fibroblasts
eventually lost p53 function. This resulted in cells continuing to divide and proliferate, thereby fueling the cancer's growth. "This occurred in 100 percent of the animals studied. It's a strong selective pressure," Van Dyke said. "Now the whole org...
Little known DNA repair enzyme may be a tumor suppressor gene
...e embryos. The investigators nevertheless isolated fibroblasts
from these embryos to see if they could be kept alive in culture. After repeated attempts, the mouse embryonic fibroblasts, or MEFs, failed to divide and died within a few weeks or months. Suspecting that the MEFs were dying because they were self-de...
Proteins are key to cell death in heart disease, stroke and degenerative conditions
...ment and died within the first day of life. "Using fibroblasts
from these mice, we were able to determine that a lack of these two proteins renders individual cells highly resistant to dying," said first author on the study Saquib A. Lakhani, associate research scientist in the Department of Pediatrics and the S...
First different black/white mechanism in pulmonary fibrosis/scleroderma identified
...ct of hepatocyte growth factor is impaired in lung fibroblasts
isolated from African-Americans," APS Physiology A...t antifibrotic effects of HGF are impaired in lung fibroblasts
isolated from Africa-Americans may be due to the deficiency in c-Met receptor function," Bogatkevich...
News tips from The Journal of Neuroscience
...s or NG2 cells that were twice as long as those on fibroblasts
or a polylysine surface. NG2 cells overexpressing NG2 did not inhibit neurite outgrowth; neither did NG2 cells with reduced NG2 expression. Thus, an attractant or adhesive role of NG2 cells appears not to depend on expression levels of NG2. 3. Exp...
U-M scientists target key cells and signals that trigger pulmonary fibrosis
...jured area. Once in the lung, fibrocytes turn into fibroblasts
cells that secrete collagen, growth factors and other substances to form scar tissue and help heal the damaged lung. Once repairs are complete, chemical signaling molecules called prostaglandins shut down the influx of fibrocytes and turn off the fi...
JCI table of contents: June 22, 2006
...ent. An example of such cells are tumor-associated fibroblasts
that make collagen type I, which play a role in th...pecifically targeting and killing tumor-associated fibroblasts
with an orally delivered DNA-based vaccine, they can significantly suppress the growth and spread of...
Mapping system tells skin cells whether to become scalp, palm tissues, Stanford study finds
...sts analyzed the gene-expression profiles of adult fibroblasts
from more than 40 areas of the body. They found ab...has this code," said Rinn. "I like to think of the fibroblasts
as wise, old parental cells who may tell the others how to behave." Their input is invaluable during...