Discovery might improve design, effectiveness of anti-cancer drugs
...or might be improved further -- by expanding it to fill the gap -- which is important in designing drugs. "Moreover, this specific enzyme is known to inactivate the anticancer agent cytarabine," he said. "That inactivation limits the effectiveness of cytarabine in cancer tissue such as in non-Hodgkins lym...Mail-order drugs exposed to extreme heat become less effective
...ity of ordering medications by mail, retailers who fill prescriptions by mail must place additional focus on the proper packaging and shipping requirements for at-risk medications," said Paul A. Kvale, MD, FCCP, President of the American College of Chest Physicians. "It also is important for patients to ...'Broken' gene reveals evolution of salt retention and possible ties to hypertension
... adult contains about 250 grams of salt, enough to fill three small saltshakers. This salt is constantly lost through sweat and urine and replaced through the diet. Salt is now "so common, so easy to obtain and so inexpensive," according to Mark Kurlansky, author of a recent history of salt, "that we h...Fat buildup found in hearts of obese or diabetic heart failure patients
...lls, which capture and store excess triglycerides, fill up. Because people have a set number of fat cells, once they are full, excess fat lodges in muscle tissue, where it wreaks molecular havoc. "The heart is a muscle, too, and it's not spared from this onslaught of fat," Taegtmeyer explained. "The heart...International marine survey of coral death
...ticipated 15-year project, the assessment aims "to fill critically important information gaps in the fundamental understanding of coral reef ecosystems so that management and policy interventions can be strengthened globally," according to C. Drew Harvell, a Cornell University professor of ecology and one...Genome of ancient fish could reveal evolutionary mysteries, Stanford scientists say
...lacanth's close relative, the lungfish, could also fill in the genetic gap between land animals and fish, but the coelacanth has one practical advantage: "The lungfish genome is enormous," said Noonan, who is now a postdoctoral fellow at the Lawrence Berkeley National Laboratory. At 35 times the size of t...Chicken genomic sequence yields insight into vertebrate evolution
... a clade of at least 9,600 avian species, helps to fill the evolutionary gap between teleost fish and mammals. An unusual genomic organization A remarkable characteristic of avian genomes is the large variability in the size of their chromosomes. In addition to a pair of sex chromosomes (Z and W), c...INEEL-designed system assists army with chemical weapon destruction
...ctroscopy system, or PINS, identifies the chemical fill the munition may contain. Operations began with the evaluation of drums containing Chemical Agent Identification Sets, which were produced by the Army from 1928 to 1969. These sets are glass ampules or bottles that contain small amounts of both neat...Where the brain harbors unconscious fears
...nts, the researchers first asked the volunteers to fill out a questionnaire that determined their basic level of anxiety. They then told the volunteers only that they were to identify the color of the faces they would see. The researchers then presented the volunteers with either fearful faces or neutral ...DFG loosens eligibility requirements for the Emmy Noether Programme
...o counter the current lack of junior scientists to fill future university lecturer positions in computer science by providing particularly qualified young computer scientists with an attractive route to attaining academic independence soon after finishing their doctorate. The Steering Committee and review...Violent ocean motion no magic potion for reefs
...orcing them and their predators away, and HABs can fill ledges and crannies that attract lobster. Ongoing funding from the Environmental Protection Agency that began in 2003 had allowed Lapointe and his team to study two isolated reefs off Palm Beach County that had become almost completely covered in la...Want to petrify wood without waiting a few million years? Try this
... to make fiber-type materials," where the minerals fill in wood-grain openings....Scientists find missing link between whale and its closest relative, the hippo
... and colleagues Michel Brunet and Fabrice Lihoreau fill in this gap by proposing that whales and hippos had a common water-loving ancestor 50 to 60 million years ago that evolved and split into two groups: the early cetaceans, which eventually spurned land altogether and became totally aquatic; and a larg...Molecular biology fills gaps in knowledge of bat evolution
...that uses molecular biology and the fossil data to fill in many of the gaps. Springer coauthors the paper...t is now North America. This latest research helps fill gaps in the evolutionary history of one of the most diverse group of mammals on earth and the only m......sly unknown. The method not only portends a way to fill in the blanks in any organism's genome but also to compare the genomes of different organisms and their evolutionary relationship. The new tools and approaches offer the most-comprehensive-to-date "functional annotation," a way of assigning the myst...Grid expectations for networked computing: From global Earth monitoring to black hole detection
...data have now been archived, enough information to fill 20 million filing cabinets. The need to handle these much data and make them available to users has led ESRIN to take up Grid technology. "We have begun an Earth Science Grid-On-Demand service based on our local Grid," explained organiser Luigi Fusc...Study finds direct association between cardiovascular disease and periodontal bacteria
...es the role of the oral pathogens themselves. To fill this void, the National Institute of Dental and Craniofacial Research launched the Oral Infections and Vascular Disease Epidemiology Study (INVEST), a multi-disciplinary endeavor whose principal investigator is Dr. Desvarieux. The study, which is th...Chemical analysis of mushrooms shows their nutritional benefits
...fungi could be tailored into dietary plans to help fill various nutritional needs. Using modern analytic tools, scientists at the University of Illinois at Urbana-Champaign found that the six mushroom varieties tested -- in raw and cooked forms and at various harvest times and maturity levels -- are rich ...Open microfluidic and nanofluidic systems
...crocompartments. However, if one actually tries to fill these channels with a certain liquid, one observes that the liquid often refuses to enter the channels. In fact, as shown in the new PNAS study, liquids at surface channels can attain a large variety of different wetting morphologies including locali...Brain controls robot arm in monkey, University of Pittsburgh researcher reports at AAAS
...limited information from relatively few neurons to fill in the missing signals. The algorithm decodes the cortical signals like a voting machine by using each cell's preferred direction as a label and taking a continuous tally of the population throughout the intended movement. Monkeys were trained to rea...