New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
...ey emerge. Using the virus' genome sequence, whose final three genes are being published simultaneously this week in Nature, Tumpey's group created a live virus with all eight of the Spanish flu viral genes. The genome sequence information was recovered in fragments from lung autopsy materials and lung tis......ws that UPF1 can be mounted on both EJC types; the final effect is the same to efficiently break down faulty RNAs. Niels Gehring, who headed the project, did extensive studies with colleagues in the MMPU to understand exactly how the pieces of the EJC fit together. "By slightly altering some of the compon...Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning
...hway transporting carbon from plants to soil. As a final check the researchers examined both the cores with and without Collembola for a particular phospholipid fatty acid (PLFA) that is characteristic for AM mycelia. They found that this particular PLFA contained significant amounts of 13C in cores not ex...Double trouble: Cells with duplicate genomes can trigger tumors
...ast cells with a compound that interfered with the final step of cell division, causing many of them to have the extra chromosome set. To make the cells more likely to become malignant, the researchers used cells that lacked a protective gene, p53 that is inactivated in many forms of cancer. Compared with ......serve and enforcement are working," says Reed. A final goal for the cruise will be to collect samples of Oculina coral whose genetics will be analyzed back on land and compared against that of Oculina found in shallow water, which is much more common. The purpose will be to determine if the deepwater ver...Important factors involved in the synthesis of starch in plants
...the biosynthesis of starch, sucrose and starch are final products of two unidirectional routes that take place in the cytosol and the chloroplast respectively. Moreover, this model takes it that the ADPglucose pyrophosphorylase (AGP) is the only enzyme responsible for the biosynthesis of the starch precurs...Study provides insight into cellular defenses against genetic mutation
...ines that re-assemble end to end only exons in the final template for protein construction. In recent years... a stop reading signal occurs too far ahead of the final exon in the chain, as marked by an exon-exon junction complex (EJC), the cell concludes that the sto...Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2005
...the first research proposals are just entering the final stage of the review and approval process, the nanoscience center's bank of computers--the theory cluster--is up and running. The theory cluster will provide nanoscience center researchers and users with computing resources for modeling the theoretica...Pall Corporation presents approach for speeding vaccine production to Shanghai conference
...posable prefilters, sterilizing grade capsules and final filters to provide exponential time, cost and labor savings. He framed Pall's total process management approach in the context of cGMP Annex 13, effective May 2004 in Europe, which specifies additional constraints for the manufacture of clinical grad...New imaging method shows early in treatment if brain cancer therapy is effective
...ks into treatment more than two months before the final MRI scan researchers could identify which patients would have a response to therapy over those with progressive disease. This corresponded to patients' survival, with those classified as having progressive disease living an average 8.2 months while ...California's oak woodlands face a new threat: Climate change
...oject what California's climate may be like in the final decade of the 21st century, assuming a "business-as-usual" scenario for ongoing emissions of greenhouse gases. Based on those projections, they predicted the potential ranges for blue oak and valley oak under the new climatic conditions, and compared...New monoclonal antibody therapies offer significant survival advantage for breast cancer patients
...al of patients than receiving paclitaxel alone (no final data available yet). Importantly the progression-free survival was improved with combination therapy, 10.97 months vs 6.11 months for paclitaxel alone. In addition, the investigators noted that combination therapy did not cause significant toxicity e...Travelers can avoid jet lag by resetting their body clocks
...atonin or matching placebo. The study ended with a final phase assessment on day 14. The researchers found that those given melatonin experienced significantly larger phase advances -- the 0.5 mg group at 2.5 hours and the 3.0 mg group at 2.6 hours versus the placebo group at 1.7 hours. Moreover, the parti...UK's first optical network gives boost to e-Science
...the first phase was completed this summer when the final three of nine UK academic sites were connected. Some of the demonstrations at SC05 will push data transfer rates beyond their present limits, whereas others will show how UKLight's enhanced quality of service is enabling researchers to tackle chall...Brainstem blocks pain to protect key behaviors
...n't urinate are at high-risk for infections.) As a final test the authors used drugs to inactivate the VMM. This completely eliminated the delayed response to pain. "This is the best evidence so far on the biological significance of OFF cell activity," said UCSF's Fields, who was not connected with the stu...Gene variants predict heart muscle damage after cardiac surgery
...esult of the action of the heart-lung machine. The final polymorphism in a gene that codes for the enzyme catalase appears to be involved in mediating the effects of oxidative stress. The normal version of the gene produces proteins that can blunt the negative effects of oxygen free radicals, while the p...New marine research shows global warming may affect organic matter recycling differently
...ounds. "The microbes responsible for all but the final step of organic matter degradation in sediments are often ignored, and we were interested in opening the microbial 'black box' in sediments and clarifying the temperature controls on different microbial groups," said Weston. Weston and Joye studied s...Innovative research set to push boundaries of cancer care
...accines were given every month thereafter, and the final dose was delivered after six months. The vaccine is designed to boost a patient's immune response to pancreatic cancer cells that may still exist despite surgery and chemo-radiation treatment. It was derived from cancer cells extracted from two pati...Missing fossil link 'Dallasaurus' found
... history on land; then in the Late Cretaceous, the final stage of the age of dinosaurs, one group moved into the sea and rose to the very top of the food chain," explains Polcyn, director of SMU's Visualization Laboratory, part of the university's geological sciences department. "Starting out as small anim......her a programme of further tests which will be the final stage of the pre-clinical work." The project is being managed by the University's intellectual property company UMIP. Project manager Gordon Barker said: "Ai2 aims to become a significant player in the global anti-infectives market by identifying unm...