New compound effectively treats fungal infections
... process and removes wrongly added amino acids. To find out how exactly AN2690 blocks leucyl-tRNA synthetase Stephen Cusack, Head of EMBL Grenoble, and his team generated crystals of the enzyme bound to tRNA in the presence of AN2690. Examining them with the high-intensity X-ray source at the European Syn...Weill Cornell team identifies potential new cancer drug target
...on is entirely unclear. "We wondered if we could find out how XIAP induces the NF-kappa B pathway," explains lead researcher Dr. Miao Lu, a postdoctoral fellow of biochemistry at Weill Cornell. In their experiments, the researchers used a variety of cutting-edge techniques, including X-ray crystallogr...Scientists close in on missing carbon sink
...ems, especially trees, take up the remainder. To find this terrestrial carbon sink, scientists have turned to computer models that combine worldwide wind patterns with measurements of carbon dioxide taken just above ground level. The models indicate that northern forests absorb about 2.4 billion tons pe...Researchers isolate new risk marker for overweight children
...nt of CVD, they feel more tests need to be done to find out why. They currently don't know if a diet of sugary, high-fat foods is the sole cause of high levels of apoB48 in children or if high levels of apoB48 are the result of a genetic imbalance that does not allow some people to metabolize sugary, high...Mathematics reveals genetic pattern of tumor growth
... we know what cancer is doing, we might be able to find ways to fight it. Previous studies have observed this genetic pattern by using laboratory techniques, but the UCI research is the first to explain why the pattern leads to tumor growth. The occurrence of genetic instability is often debated by canc...International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
...an said. "Wherever we look along the ridge, we find vents," he said, "and the vents in different regions of the ocean host very different animals." "The biggest challenge for the future of our research is to design more efficient ways of exploring the remaining 90 percent of the ridge crest," said G...Researchers pit novel version of common virus against cancer
...annot give people HIV, explained Kim. So we had to find another route. Thats when we came up with the idea of modifying the adenovirus with dNTP. Thus, the Rochester team set out to construct a new weapon. Their adenovirus vector contains mutant DNA polymerase (dNTP) that should activate only in cells w...Wright State scientist receives grant to help clean up polluted American harbors
...ity in Dayton, Ohio. Given these costs, we have to find better ways to determine what does and does not need to be cleaned up. Burton, an expert on the pollution of aquatic systems, has received an innovative $900,000 grant to help develop a solution for this environmental dilemma. He said virtually ev...New tumor markers -- 'Spot the differences'
...en we solve Spot the difference puzzles, we try to find out what makes drawing A different from drawing B; in this case, which messages are being sent by cancerous cells but not by normal cells. However, here we do not have easy drawings with just a few lines as in a puzzle (Figure A). Instead, we compare...Scientists ponder plant life on extrasolar Earthlike planets
...yll absorption going on. A third way yet to find extrasolar planets is to look for wobbly stars bec... NASA has two missions in the works designed to find possible evidence for life on extrasolar planets. One features a space-based instrument that will m...Another sexual attraction is possible ...
...ny offspring, or - in the unlikely event that they find a mutant partner - they might found a new line that may eventually become a new species. As such, the offspring of such parents would inherit the mutant communication system of their parents, which could "spark" the divergence leading to the formatio...Weizmann Institute scientists develop a general 'control switch' for protein activity
... proteins, and in the future the new technique may find many additional uses. The switch has a genetic ...at a small set of engineered proteins is needed to find the ones that respond to the drug. With their greater resources, biotechnology companies will be abl...Gannet population under threat from global warming
...nough, it will eventually leave the nest itself to find food. This leaves the chick alone and vulnerable t... forced to travel as far as the Norwegian coast to find food a round trip of over 1000km, said Dr Hamer. They compensate by flying faster to make sure they...Fever after smallpox vaccination tied to individual genetic variations
...ebrile seizures after MMR, Stanley says. If we can find ways to identify people at risk and medicate them to reduce the possibility of fever, we might be able to reduce the incidence of seizures. ...UI anthropologist, colleagues discover remains of earliest giant panda
...ons of years says Ciochon. Ciochon says that the find further helps establish conditions that existed in the region during the varying climatic conditions of the Pliocene and Pleistocene epochs, stretching back some three millions years before the present. The pygmy giant panda lived in lowland tropical...PINK1 protects from Parkinson's
...ne TRAP1 to promote cell survival. The researchers find that PINK1 normally protects against oxidative-stress-induced cell death by suppressing cytochrome c release from mitochondria. The PINK1 mutations linked to PD impair the ability of PINK1 to phosphorylate TRAP1 and promote cell survival. These findi...Human genetic 'deserts' are teeming with significant life
...ng the human genome the consortium members hope to find the most effective ways of analysing it in its ent...d they could impair cloning strategies that try to find genes implicated in these pathologies. They also suggest that extra caution should be used when as...Researchers discover 'acquired' DNA key to certain bacterial infection
...nitial immune response. The researchers did not find a similar island of acquired genetic material in two similar bacteria, Mycobacterium tuberculosis and Mycobacterium paratuberculosis, which causes Johnes disease. M. avium exists in the environment and is thought to infect humans when the infected ...Potent possibilities for parasite attack
... this comparative genome study provides a route to find those that might be essential to each species. One potential target is the CFAS gene that codes for cyclopropane fatty acid synthase, an enzyme that may be involved in producing components of the cell membrane. CFAS is present in the genomes of L. ...Ancient Etruscans were immigrants from Anatolia, or what is now Turkey
...nks between the two regions have been difficult to find until now. Herodotus theory, much criticised by subsequent historians, states that the Etruscans emigrated from the ancient region of Lydia, on what is now the southern coast of Turkey, because of a long-running famine. Half the population was s...