New therapy for specific form of leukemia
...genetic code of ABL1 is at chromosome 9. Through a flaw at the ABL1 gene, a piece of DNA is split off and 'takes on a life of its own' as it were. This fragment contains the ABL1 gene, connected to another gene. Due to this fusion, ABL1 works non-stop − stimulating cell growth unremittingly. This pr...Yale book offers new paradigm for building design
...ver, as more of a design failure than an intrinsic flaw of contemporary life." "Building for Life" examines what is known about how the natural environment affects people's physical, mental and spiritual well-being and the role of nature in childhood development. It explains the relationship between peopl...New cellular flaw found in some virulent breast cancers
...ed oncogene and the newly described growth control flaw is seen in about 10 percent of breast cancers and the deadliest ones. The cancer results from a cascade of molecular events. The overproduction of a common protein, cyclin D1, hyperstimulates a growth switch, CDK4 kinase, causing it to unleash a vir...Common food preservative might provide treatment for cystic fibrosis
... in the lungs of cystic fibrosis patients--a fatal flaw that leaves the organism vulnerable to destruction...n as mucA--in the organism also represents a fatal flaw that could help physicians clear the characteristic "goop" from the lungs of advanced cystic fibrosi...New study reveals Rett syndrome can strike males
... syndrome only affects girls, and that the genetic flaw would be so serious in boys that they would die before birth," Dr Leonard said. "Worldwide there have only been 11 previously established cases in boys who have presented early in life with a severe clinical picture of progressive neurological decl...Tracing the pathways of neurofibromatosis
...n mutant fruit flies, each with a specific genetic flaw that testified to the power of one or more proteins involved. Neurofibromatosis is characterized by the formation of tumors of peripheral nerve cells. Scientists know the disease is caused by defects in a gene called Nf1, but they have yet to find ...First demonstration of muscle restoration in an animal model of Duchenne muscular dystrophy
...the Department of Physiology at Penn. This genetic flaw causes from 5 to 15 percent (and in a few instances up to 70 percent) of individual cases of most inherited diseases, including DMD, cystic fibrosis, and hemophilia. The new drug, developed by the South Plainfield, NJ-biotech firm and called PTC124...... find out that a particular illness is caused by a flaw in dynamin 1 function or proteins that interact with dynamin 1, we'll have answers on hand to help fix that." Dynamin 1 is one of a family of enzymes involved in synaptic vesicle endocytosis -- a reverse of the process of transmission of cellular s...