U-M researchers discover gene switched off in cancer can be turned on
...d found the BRM expression could be restored like flipping the switch back on. While the existing HDAC inhibitors did return BRM expression, the effect was short-lived. Once the drugs were taken away, BRM expression decreased. The HDAC inhibitors are not the perfect answer, but in principle this tells us...Marine moss reveals clues to anticancer compound
... non-Hodgkin's lymphoma and melanoma that involves flipping a switch that makes the cancer cells behave like normal cells. Bryostatin 1 is even in phase I and II clinical trials alone and in combination with other drugs. But the problem has been getting the bryostatins in the large quantities needed for pha...Molecular 'on/off switch' controls immune defenses against viruses
DALLAS Dec. 25, 2006 -- Much like flipping a light switch, the hepatitis C virus turns on human immune defenses upon entering the body but also turns off those defenses by manipulating interaction of key cellular proteins, UT Southwestern Medical Center researchers have found. This same mol...Scientists discover role for dueling RNAs
...s from which they originate. But in some cases, flipping the meiotic switch can be catastrophic. If a cell with only one copy of each chromosome (a haploid cell) is forced into meiosis, the progeny won't survive. Fortunately, such destructive meiotic division is avoided in haploid cells because they contin...Evolution of Old World fruit flies on three continents mirrors climate change
...ing part of a bar code from a consumer product and flipping it backwards. The biologists found that the frequency of particular inversions was correlated with the latitude where a given insect was found. Inversions that were common in the north were uncommon in the south, and vice versa. The fruit flies we...How HIV 'exhausts' killer T cells
... can simply "turn off" fully functional T cells by flipping a molecular switch on the cells. In test tube studies, however, the scientists showed that they could reinvigorate the killer T cells by blocking that inhibitory switch, which is called programmed death-1 (PD-1). The study's senior author, Bruce ...ANU scientists crack DNA replication mystery
... separation near TUS leads to one of the DNA bases flipping over and inserting itself like a key in a lock in a perfectly shaped pocket on the surface of TUS. TUS is locked onto the DNA and this stops the replisome snowplough in its tracks." Professor Dixon said the discovery was important "not just because...Kidnapped: Colon cancer seizes hapless nerve growth protein
...l life on its head. No form of cancer is better at flipping normal cell mechanisms for growth and movement into sinister contraptions for evasion and invasion than aggressive colorectal tumors. Kidnapping is a particular talent, especially along the cancer's invasive edges. That's where Avri Ben-Ze'ev and col...Scripps scientists describe protein used by bacteria and cancer cells to resist drugs
...a because they help them build their cell walls by flipping molecules like "lipopolysaccharide" (LPS) and "lip...ecules are components of bacterial cell walls, and flipping them from the inner to the outer membrane of bacteria is necessary for bacterial cell growth. The ...Researchers discover mechanism for multiplying adult stem cells
...he process is reversible. Discovering that simply flipping a single gene on and off has such an immediate effect on a tumor was unexpected, even though Oct4 is known to be active in certain forms of testicular and ovarian cancer. Still, the most provocative finding was that "Oct4 causes tumors by preventing ...