Unlocking proteins from their cellular shell
...interactions. Future efforts will focus in part on folding of cytoskeletal proteins that are targets of gene therapies and also on clarifying signaling processes in cells that couple to protein folding. The latter processes often entail modification of proteins with phosphates and are essential to how indiv...Protein pulling -- Learning how proteins fold by pulling them apart
...could be of widespread use in the field of protein folding science, which has grown dramatically in the past ...ly how much free energy is required throughout the folding process. "We believe the method can be applied to any protein," said lead author Ching-Hwa Kiang, ...Bird sized airplane to fly like a swift
...ing means the wings can be swept back in flight by folding feathers over each other, thus changing the wing shape and reducing the wing surface area. RoboSwift also steers by morphing its wings. Doing so, the micro airplane can perform optimally, flying efficiently and highly maneuverable at very high and ve...JCI Table of Contents -- July 2, 2007
.... TITLE: An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis AUTHOR CONTACT: Mitchell J. Weiss The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Phone: (215) 590-0565; Fax: (215) 590-4834; E-mail: weissmi@email.chop.edu View t...Invertebrate immune systems are anything but simple, conference finds
...olecule found in fruit flies, Dscam, is capable of folding itself in 18,000 different ways. Computer models ... molecule have led scientists to suggest that this folding creates different shapes, each capable of binding to different structures on the pathogens surface. ......er switch. Other DNA sequences are responsible for folding and packing DNA into the nucleus of each cell. Five percent to 50 percent of DNA is considered useless junk, depending on who you ask, although probably at least half of the junk DNA is going to end up having a pretty important function, Capecchi ...NIH awards nearly $21 million to fund cutting-edge research equipment
...; and to research protein structure, function, and folding at the University of Connecticut School of Medicine and Dentistry in Farmington. Three high-performance, hybrid linear ion trap-Fourier transform mass spectrometers will be funded. One will be located at Johns Hopkins University in Baltimore, Md., ...A new wrinkle in evolution -- man-made proteins
...anted to learn more about the evolution of protein folding and stability." Chaputs group decided to speed ...ubtle amino acid changes contribute to the protein folding and stability. Chaputs team has developed the technology potential to take any of natures proteins a...Decoding protein structures helps illuminate cause of diabetes
...s to capture series of snapshots during individual folding reactions to identify multiple phases as the proteins convert from an unordered mishmash into flat sheets, then coil into fibers. "No matter how fast they're moving, we can take pictures of them," says Zanni. Without their automated method, he sa...Scientists identify prion's infectious secret
...signed the arrays so that he could observe protein folding and amyloid formation in real time. Tessier covered the array with peptides from bakers yeast and then added prion protein to the array, also from the same yeast species. He found that a small cluster of peptides recruited the prion proteins to mi...Yale biophysicist Thomas Steitz receives Gairdner Award for medical research
...atrics was cited for his discoveries about protein folding in the cell and its relevance to neurodegeneration. ...MIT model helps researchers 'see' brain development
... development in diseases like autism by looking at folding differences, said Fischl. This tool may also be used to shed light on other neurological diseases such as schizophrenia and Alzheimer's disease. ...2007 Amgen Biochemical Engineering Award
...inal discoveries in the areas of oxidative protein folding and protein secretion. His awards and recognitions include his election to the National Academy of Engineering in 2005; the 2003 Professional Progress Award of the American Institute of Chemical Engineers (AIChE); the 2003 Marvin J. Johnson Award in ...Physicists reveal water's secrets in journal Science
...cations, from biological investigations of protein folding and other life processes, to the design of the next generation of power plants. The research is reported in the article "Predictions of the Properties of Water from First Principles" in the March 2 issue of Science, a prestigious international jour...Instruction manual for creating a molecular nose
...ing detergents. However, this destroys the natural folding structure of the protein membranes, which is precisely what makes the proteins so special. "We quickly realized how difficult it is to isolate such membrane proteins. Neither we, nor other research groups, were able to work with them using convention...Scripps research study reveals structural dynamics of single prion molecules
...f Sciences, offer significant insights into normal folding mechanisms as well as those that lead to abnormal amyloid fibril conversion. The new insights may lead to the discovery of novel therapeutic targets for neurodegenerative diseases. Intriguingly, certain prions and amyloids can play beneficial roles...USC team reveals structure of APOBEC family protein
...ity. They showed that some mutations stop AID from folding and therefore working properly, while others block its ability to interact with DNA and RNA molecules. "The x-ray structure of Apo2 provides a clear direction for research on therapeutic strategies to deal with problems arising from either the fail......iological systems, and can give insight in protein folding and stability. The researchers publish their results this week in PNAS Early Online Edition. The repulsion of water is a phenomenon present in many aspects of our lives. Detergent molecules made up of components attracted to water (hydrophilic) and...Comprehensive model is first to map protein folding at atomic level
...ng cells. The technique, which can track protein folding for some 10 microseconds -- about as long as some ...nction. Our paper provides a first solution to the folding problem, for small proteins, at an atomic level of detail." Fiendishly intricate, protein folding ...NSF awards $4.5 million to researchers for study of protein folding mechanisms
...to shed new light on what is known as the "protein folding problem" -- the deciphering of rules for encoding ...gical Research program to study the effects of the folding environment on protein folding mechanisms. The award is one of three awarded by the NSF totaling ...