Finding could improve safety of stem cell transplants
...ing used to further reduce the chances of teratoma formation and make stem cells extremely safe," Dr. Condie says. "This is something that you want to have zero doubt about." The next step is to look at an intact mouse embryo to see if the identical processes are at work. ...New method to measure ancient land elevation developed by Field Museum scientist
...n since isolation is an important mechanism in the formation of species. In addition, high mountains and large plateaus (such as those in Tibet and Colorado today) have always had a big influence on climate by altering patterns of atmospheric circulation. Because this new method is independent of variations in...Novel AT2R gene transfer prevents hypertension-related enlarged heart, cardiac fibrosis
...ng of the ventricular walls. It also prevented the formation of fibrosis an extracellular matrix like collagen -- that makes it harder for the heart to pump." Without AT2R protection, left ventricular wall thickness (LVWT) increased 123% and the heart weight to body weight ratio (measuring overall "enlargeme...Shark cartilage cancer 'cure' shows danger of pseudoscience
...nts in which the substance seemed to inhibit tumor formation and the growth of new blood vessels that supply nutrients and oxygen to malignancies. "The fact is that it is possible that highly purified components of cartilage, including from sharks, may hold some benefit for treatment of human cancers," ...JCI table of contents, December 1 2004
..., cause inflammation in the vessel and, over time, formation of a lesion. A family of proteins known as PPARs ...E: Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. AUTHOR CONTACT: Andrew C. Li or Chr...Zebrafish study yields observation of muscle formation
...l development in zebrafish embryos. Looking at the formation of two types of muscle fibers, Henry and co-author...Maine. The authors show that cells leading to the formation of so-called "slow twitch" muscle fibers can induce the formation of "fast twitch" fibers. These two...Cigarette smoke a culprit in poor healing and increased scarring
...ogy (ASCB). Cigarette smoke delays the formation of healing tissue and sets the stage for increased...ells at the edge of the wound, thus preventing the formation of the healing tissue," she said. Martins-Green added that: "We're now trying to ...Draft sequence of chicken genome completed
...duction, whereas birds use a different set for the formation of feathers and claws. We also found some chicken genes involved in immune function that previously were believed to be unique to humans." An international consortium of over 170 people from 49 different institutes across the globe assembled and anal...Children's Hospital Boston launches major genetic study of autism
...pects of brain development and function, including formation of synapses. Mutation of one gene that regulates BDNF, called MeCP2, has already been linked to Rett syndrome, which is characterized by mental retardation and autistic behaviors. Further studies of MeCP2 and related genes will explore how they work ...Injectable gel could speed repair of torn cartilage
...mice, which are commonly used to examine cartilage formation in a physiological environment. The material was g...d with exposure to ultraviolet light and cartilage formation was examined over the course of three months. The material produced progressively higher amounts of ...Discovery about Vitamin C explains its metabolic value
...y, which had found vitamin C to be involved in the formation of compounds potentially damaging to DNA. But that research, the scientists say, only provided part of the story about what actually happens in the human body. The newest findings explain for the first time how vitamin C can react with and neutralize...Dwarf mistletoe reveals its sexual secrets
..."In all previously described flowering plants, the formation of the egg and its accessory cells is thought to trigger a chemical signal that causes the pollen tube to find the egg and fertilize it. But with my dwarf mistletoe, the pollen tube, which contains the plant's sperm, grows down through the young flow...Fewer calories may slow Alzheimer's
... The researchers were looking specifically at the formation of plaquescaused by a build-up of the fiber-like substance called beta-amyloid. Made up of proteins and polysaccharides, amyloid plaques aredeposited in the brain during Alzheimer's disease. Specifically,plaques accumulate in the hippocampus an...New model of rare childhood blindness holds promise for testing preventive therapies
...earchers also hypothesize that AIPL1 regulates the formation of rod cells during the late stages of development...y discovered that the gene Rb is essential for the formation of photoreceptors in the retina; and Sohocki's laboratory cloned the AIPL1 gene and was the first to...Researchers improve predictions of cloud formation for better global climate modeling
...itations of current methods for representing cloud formation in global climate models important because of inc...oad range of scale. "Equations that describe cloud formation simply cannot be implemented in climate models," Nenes said. "We don't have enough computing power -...New route to Parkinson's found in cells' 'garbage disposal' system
...ctivity. This inhibition, they found, enhances the formation of protein aggregates, and this formation was inhibited when the researchers shut down the activity of BAG5. In other test tube studies, the r...JCI table of contents, December 15 2004
...to accelerate bone loss in mice and also block the formation of human BMSSCs. The study offers a novel concept of how caspase-3 deficiency alters the development of stem cells leading to osteoporosis. Given the demonstrated influence of the caspase-3 inhibitor on bone mineral density, the authors highlight t...... individual celestial objects. His research on the formation of galaxies has contributed decisively to massive black holes in the centre of galaxies being regarded as the seeds for their formation, rather than the product of their development. Gnther Hasinger is currently involved in studying the cores of acti...Solving the mechanism of Rett Syndrome
...pe mice, they found that MeCP2 is required for the formation of a loop of silent chromatin between the Dlx5 and Dlx6 genes, by bringing together two sequences separated by more than 10,000 base pairs. This silent chromatin loop configuration could not be formed in MeCP2-null brain, and in MeCP2-null mice, the ......on of VEGF, a protein that stimulates blood vessel formation and is found at very high levels in gliomas. Blood vessels in gliomas and many other tumors are abnormal and do not deliver oxygen to tumor cells as efficiently as normal blood vessels do in normal tissues. This is clinically significant because lack...