New therapy for specific form of leukemia
...without fully reaching maturity. These blood cells function inadequately, disrupting the production of normal ...ocess of cell division. It is crucial that kinases function in a very controlled manner within our cells. Loss of control of their functioning disturbs the norm...US researchers show cottonseed drug is cancer treatment booster
... (minus gossypol)[2], inhibited the anti-apoptotic function of Bcl-2/xL in cells, and increased induction of apoptosis (programmed cell death) and made the tumours more sensitive to radiotherapy in human prostate tumours in mice. The study demonstrates for the first time that (-)-gossypol enhances the anti-tu...Commandeering cellular machinery: recognition mechanism to detect small molecules
...ly more sensitive than others. Some performed the function of on-off switches, while others were more like dimmer switches, responding in proportion to the amount of LG335 bound to them. Doyle's team also studied their re-engineered receptors in mammalian cells and found they behaved much the same as in yea...Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
...f Rank Ligand activity does not interfere with the function of osteoblasts, the cells involved in bone formation. AMG 162 Study Design Investigators randomized 411 postmenopausal women, average age 63, with low lumbar spine BMD to receive AMG 162, placebo or FOSAMAX®. The primary endpoint of the study...Columbia University scientist wins 2004 Nobel Prize
... gene into any cell, allowing the analysis of gene function in vivo. These experiments in cell transformation led to the isolation and functional analysis of the gene for the T-cell surface protein, CD4, the cellular receptor for HIV. He then began to apply the techniques of molecular biology to problems in...HHMI researchers Richard Axel and Linda Buck win 2004 Nobel Prize
...them a characteristic, snake-like shape. They also function in similar ways, by interacting with G proteins to transmit signals to the cell's interior. Since many receptors of this type share certain DNA sequences, Buck designed probes that would recognize these sequences in a pool of rat DNA. Next, she assum...Talented sniffer: A receptor known for guiding sperm to egg plays a role in the nose
...s, whereas they tested and demonstrated the actual function of the receptor in a simple "sniffing test" as wel...dings show that, interestingly, the basic receptor function of hOR17-4 seems to be identical in both human sperm and olfactory neurons. In light of their findin...Below the surface: New clues to plant signaling from the roots
... identify a gene, called BYPASS1, which appears to function in the coordination of root and shoot growth by re...s of mutant Arabidopsis plants that lacked BYPASS1 function constitutively produced this growth-inhibiting substance. If the mutant roots were removed, the muta...Putting physiology into the Nobel Prize: 2004 marks 100th anniversary of Pavlov's award
...ship between the brain and the control of visceral function presents itself," Smith added. Some of Pavlov's ot...logical and the physiolo-gical intermingled in the function of the central gastric secretory neural center, and, therefore, their combined effects were expresse...Protein energy profiles offer clues about amyloids
... at Rice University. "In the first, proteins don't function correctly because they fold into the wrong shape. ...ieces and fuse other molecules together. Since the function of a protein is often based upon specific chemical interactions -- enzymes, for instance, are protei...New biosensor rapidly detects deadly foodborne pathogen
...ng this sensor for three years and demonstrate its function in the current issue of the journal Applied and Environmental Microbiology. The sensor is made of a small piece of optical fiber - a clear, solid, plastic material that transmits light through its core. The fiber is coated with a type of mol...Most promising clinical uses for stem cells from fat agreed on by international society
... While questions still remain about the nature and function of stem cells found in fat, a group of researchers and clinicians convened today in Pittsburgh at the Second Annual Meeting of the International Fat Applied Technology Society (IFATS) agreed that research should move forward with the ultimate goal of...University of Edinburgh hosts European conference on childhood disability
... prevent impairment, minimise disability, maximise function and improve the quality of life for affected children." Keynote lectures will include: cell mechanisms of language and learning; genetics, understanding and communication; motor disorders; optimising outcome in prematurity;epilepsy and disability; an...Biologists ID molecular block for social 'cheaters'
...tying cooperative genes tightly with the essential function of reproduction," said paper co-author Joan Strassmann, professor of ecology and evolutionary biology at Rice. "Such a mechanism makes the loss of social genes costly to cheaters, and we believe this pleiotropic mechanism may be indicative of a gener...New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
...to counter a progressive decrease in mitochondrial function in skeletal muscle of increasingly obese women. We feel that this discovery provides new insights into the primary deficits in muscle metabolisms which underlie the progression of obesity-related diseases," Hittel said. In conclusion Hittel ...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...eters being studied. IHG's effect on endothelial function Hypertension is associated with endothelial dysfu...ther McMaster study. Her group studied endothelial function after IGH to see if it played a role in the reduction of blood pressure in people taking anti-hypert...Toward a better understanding of taste and smell impairments
... Chemosensory Clinic that assesses taste and smell function of patients. Otolaryngologist Edmund Pribitkin, M....o various inhaled substances on nasal chemosensory function of three groups: (1) medical and veterinary students exposed to formaldehyde in gross dissection lab...U-M scientists see ubiquitin-modified proteins in living cells
...to a protein in ways that can change the protein's function and location within the cell. Originally, scientis...cell recycles to make new proteins. "Jun's function in the nucleus is transient and time-dependent," Kerppola says. "If it's turned on and doesn't get t...Society for Psychophysiology Research
...Dublin, Ireland Does cocaine use really affect the function of the brain? This study addressed this question ...he detrimental effects of cocaine use on cognitive function and clarify the mechanism by which cocaine adversely affects the brain. SENSATION SEEKING INFLUENCE...Experts present new research on hot topics in aging at GSA's annual meeting in Washington, DC
...durable to two years. No training effects on daily function were detected at 2 years, likely because of minima...c Status : There is a dearth of data on health and function among older African-Americans. The Health, Aging and Body Composition Study, a study of 3,075 men an...