JCI table of contents: September 1, 2006
... gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes AUTHOR CONTACT: Carlos S. Subauste Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Phone: 216-844-8590; Fax: 216-844-7117 E-mail: carlos.subauste@case.edu . View the PDF of...NYU biologists identify gene that coordinates two cellular processes
...ing GFP, a fluorescent marker, and expressing this fusion in early embryos, they visualized the movement of ...gregation and the nuclear envelope, the MEL-28-GFP fusion was observed to shuttle between the nuclear periphery and the chromosomes during cell division. Addi...JCI table of contents: September 7, 2006
...nother protein to PNP and showed that this PTD-PNP fusion protein could enter cells when it was administered...urthermore, frequent administration of the PTD-PNP fusion protein to Pnp-deficient mice corrected most of their defects, including their immune defects. This ...PNP gets a pass to enter cells
...nother protein to PNP and showed that this PTD-PNP fusion protein could enter cells when it was administered...urthermore, frequent administration of the PTD-PNP fusion protein to Pnp-deficient mice corrected most of their defects, including their immune defects. This ...DOE announces $60 million in projects to accelerate scientific discovery through advanced computing
...hese new project areas will complement research in fusion energy, global climate, turbulence, stress corrosion cracking, computational chemistry and quantum chromodynamics. In support of these scientific applications, approximately $24.3 million in annual awards will allow SciDAC-2 to establish nine Cente...Researcher lights the way to better drug delivery
...long microtubules, hollow tubelike structures, and fusion with special digestive-enzyme containing compartments within the cell called lysosomes. However, the research showed that disulfide reduction occurred even when such components were removed from the process. By inactivating different cellular compon...News tips from the Journal of Neuroscience
..." New Kv2.1 channels were delivered to clusters by fusion of adjacent surface clusters and fusion of intracellular transport vesicles that contained channels. 2. NT-3 and Axon Bridging After Inj...... different protocols by which one can initiate the fusion process in a controlled manner and observe the subsequent fusion dynamics with a temporal resolution in the microsecond regime. For both protocols, the opening of th...Critical hearing gene helps send auditory messages to brain
... as the major [calcium] sensor triggering membrane fusion at the inner hair cell ribbon synapse." The findings also have therapeutic implications, as they suggest that people who are deaf as a result of defects in otoferlin "will benefit from cochlear implants," the researchers said. Cochlear implants anal...Ossur recognized with Frost & Sullivan 2006 Innovative Technology Award
...ound-breaking prostheses that represent a seamless fusion of electronics, mechanics, and human physiology. One is the POWER KNEE TM , the world's first motor-powered knee that replaces true muscle activity, thus making it possible, for the first time ever, for an amputee to go up stairs and inclines foot-...Ossur repeats Popular Science 'Best of What's New' award
...der, president of Ossur Americas. "It's a seamless fusion of electronics, mechanics, and human physiology that reduces the energy that patients spend in reacting consciously to the environment." Expertise in real-time motion analysis for the foot was provided by Canadian company, Dynastream. Prosthetists ...Scientists harness diptheria toxin and interleukin 2 to help the immune system attack melanoma
...elanoma cells in mice." Denileukin diftitox is a fusion protein made up of amino acid sequences for the diptheria toxin and the T cell growth factor, interleukin 2 (IL2). It targets Tregs that have IL2 receptors on their cell surface, and it binds to part of the receptor called CD25. Once it reaches the...Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
..., in practice it is very different." TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion The presence of a gene fusion in prostate tumors is significantly associated with aggressive cancer, metastatic spread, and an inc...Winners of the 2006 AAAS Science Journalism Awards
...tic projections have led some critics to joke that fusion is the energy source for the future and always wil...ncertainties and controversies." A segment on cold fusion explored why a few researchers continue to study "a concept many would assume is dead," said Josh Fi...Bright future for nuclear medicine technologists
...0,470. Nuclear medicine technologists working with fusion imaging (such as PET/CT) earn higher salaries than...n of medical imaging, the increasing importance of fusion imaging technologies and the shift of nuclear medicine practice toward cardiologists, oncologists an...DNA repair teams' motto: 'To protect and serve'
... Be thankful your cells are so clever. Erroneous fusion of chromosome ends would be disastrous, leading to cell death or worse. "When DNA at telomeres is repaired chromosomes fuse together. If these cells then divide you could get chromosome breakage and genome instability, which leads to cancer," explain...Yeast model shows promise as Alzheimer's test
... be detected," said Liebman. "The system employs a fusion of the human A-beta peptide to a functional yeast ...ive in allowing cells to grow on test media if the fusion does not form aggregates." Liebman said the yeast model system can be used to develop a high throug...Protein protects against nerve degeneration
...ad three copies of a gene for a protein that was a fusion of NMNAT and another protein. Bellen and his colleagues sought to determine whether NMNAT was actually protective by studying mutant forms of it in fruit flies or Drosophila melanogaster, a commonly used model organism. NMNAT exists in a single state...Other highlights in the January 3 JNCI
...ranslocation of chromosomes 15 and 17 that forms a fusion protein between two genes called promyelocytic leu...and retinoic acid receptor alpha (RAR-alpha). This fusion protein prevents certain blood cells from maturing and leads to an accumulation of these immature le...Dartmouth researchers find that arsenic triggers unique mechanism in rare leukemia
...e swapping of chromosomes 15 and 17, which forms a fusion protein. This fusion protein prevents certain blood cells from maturing and leads to an accumulation of immature leukemia...