News tips from the Journal of Neuroscience
...es of CMT2 arise from mutations in a mitochondrial fusion protein mitofusin 2 (MFN2). This week, Baloh et al. propose that MFN2 mutations cause disease by altering mitochondrial trafficking. The authors expressed mutant MFN2 in cultured dorsal root ganglion neurons. Fragmented mitochondria clustered in cell...Together, biological membranes prevail
...ign have developed a novel method to visualize the fusion of biological membranes at the single-event resolution. Observing the individual fusion events revealed an unprecedented detailed picture of membrane fusion, which was chronicled in one of...Central and peripheral signals set the circadian liver clock
...ctive liver clock with a strain carrying the mPer2 fusion gene. As expected, liver slices from the offspring without Dox did not exhibit circadian mPer2 expression; the liver oscillators had therefore been shut off. However, when Dox was added to the medium supporting the liver tissue, circadian rhythms mat......iologists and bioengineers together to address the fusion of cell biology and engineering approaches to understand and exploit receptor-mediated cell-cell, cell-matrix, and cell-growth factor interactions. A major goal of this conference is to provide a forum for discussion of the basic cell biological and ...FISH-ing for links between cancer and aging
..., enabling investigators to easily see breakage or fusion of chromosomes that are characteristic of damaged DNA under the microscope. Then they artificially supplied the cultured cells with one of two genes-either a functional copy of the WRN gene, which is mutant or nonfunctional in Werner Syndrome, or a...EO Lawrence Award goes to 8 scientists and engineers
...mage to materials required for nuclear fission and fusion reactors and for space reactor technologies....Winners of the 2006 AAAS Science Journalism Awards
...tic projections have led some critics to joke that fusion is the energy source for the future and always wil...ncertainties and controversies." A segment on cold fusion explored why a few researchers continue to study "a concept many would assume is dead," said Josh Fi...European approval of HIV drug darunavir will provide a potent new option with Fuzeon
... build a potent new treatment combination with the fusion inhibitor, FUZEON. The combination of FUZEON and boosted darunavir has been shown to give treatment-experienced patients a better chance of achieving an undetectable viral load than boosted darunavir without FUZEON. This crucial goal of therapy is a...CSHL research ties harmless viruses to cancer
...g the body against viruses, or preventing the cell fusion that they cause may decrease the frequency of cancers and prevent their progression," said CSHLs lead investigator Yuri Lazebnik. According to this model, cells can be made cancerous by viruses that fuse cells. Fusion abruptly unites two or three c...Largest physics meeting of the year, in Denver
...ns slow, but do not stop, pandemics (P22.4) cold fusion (sessions A31 and B31) MRI imaging with 90-nm resolution, 60,000 times better than conventional MRI (A19.3) new negative refraction structures - the grism (grating-prism) and grating lens (X38.2) submicron neutron radiography (H38.10). string...News tips from the Journal of Neuroscience
...xpressed a green fluorescent protein (GFP)TrkB1.T1 fusion protein in their favorite presynaptic cells, Xenopus laevis retinal ganglion cells (RGCs). GFPTrkB.T1 did not disrupt axon pathfinding to the tectum. However, time-lapse confocal microscopy in vivo revealed abnormal features in RGCs, including axon...Swell gel could bring relief to back pain sufferers
...tions. This would compare favourably with spinal fusion - a major surgical procedure with considerable rec...antage of restoring spinal mobility whereas spinal fusion surgery results in a significant loss of mobility at the fused and adjacent discs." Dr Saunders sa...ACS News Service Weekly PressPac -- March 28, 2007
...Miles report new evidence of excess heat from cold fusion Leveraging Disorder Journalists Resources ... energy nuclear reactions (LENR)" In 1989, cold fusion was hailed as a scientific breakthrough with the potential to solve the worlds energy problems by pr...Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
...est. When the bacteria grow, they express the "GST fusion protein," which consists of a GST tag attached to ...utathione) that binds specifically to GST, the GST fusion proteins can be easily sequestered and studied in more detail. To test the activity of a certain g......other sarcomas) contain what is known as a SYT-SSX fusion gene, a mutant gene created by translocation, whic...he X chromosome, either SSX1 or SSX2. The SYT-SSX1 fusion gene results in synovial sarcoma that progresses more quickly and is deadlier, but the study involve...Mouse model advances understanding of synovial sarcoma
...arcoma is associated with expression of a chimeric fusion protein called SYT-SSX. Dr. Mario R. Capecchi, fro...e allowed the researchers to control the timing of fusion protein expression so as to examine what happens when the protein is expressed at different stages o...Veterinary scientists explore poultry virus as cancer killer
...ation, Subbiah and his associates are altering the fusion protein of NDV to replicate only in the presence of prostate specific antigen (PSA), which is found exclusively in cancerous prostate cells. Normal, healthy cells have an interferon antiviral system that activates upon infection with NDV thereby p...'Fusion' protein found by Johns Hopkins researchers
...n under a fluorescent microscope. At each future fusion point between cells that they examined in the fly ...yers in cell fusion, we get closer to manipulating fusion for our benefit," Chen adds. Muscular dystrophy, for example, might be treated by injecting into pat...Ossur's Proprio Foot walks away with 2007 Medical Design Excellence Award
...owered and intelligent prosthetic foot, a seamless fusion of electronics, mechanics, and human physiology that reduces the energy patients spend in reacting consciously to the environment. The foot replaces muscle function that was lost due to an amputation, enabling amputees to perform normal, functional a...Weizmann Institute scientists discover a key player in embryonic muscle development
...to the myoblast recognition protein, allowing cell fusion to proceed. The WIP protein has been conserved e...tinued to identify and cozy up to one another, but fusion between cell membranes did not take place, and multi-nucleated muscle fibers failed to form. An arti...