Tag: "gene" at biology news
Air pollution link to clogged arteries
...sion profiling. This allowed the identification of gene
modules containing a high number of co-expressed g...llutant diesel particles, and saw some of the same gene
modules upregulated. The American Cancer Society has reported a six percent increase in cardiopulm...
UCLA study links air pollution to clogged arteries
...l particles and saw activation of some of the same gene
groups in the animals tissue. Exactly how air pollutants cause cardiovascular injury is poorly understood, Nel said. But we do know that these particles are coated with chemicals that damage tissue and cause inflammation of the nose and lungs. Vas...
Females more prone to brain damage from alcohol abuse
..."We designed the experiment to be able to identify gene
expression differences between lines of mice that ...en said. After identifying the alcohol-regulated gene
pathways, Wiren and Hashimoto were able to home in on the extent of cell death. Ten days after alcoh...
Study identifies new gene therapy tools for inherited blindness
July 25, 2007 -- An improved approach to gene
therapy may one day treat some of the nearly 200 i...blindness are turned on. "In its most basic form, gene
therapy requires three components," explains Joseph Corbo, M.D., Ph.D., assistant professor of patho...
Call for EU to launch major project to map out all our proteins
...sis of the genome. This is a surprise because each gene
had been understood to code for a protein on a one... thats the most direct evidence we can have that a gene
really exists, said Aebersold. It will though be hard to tell when the job is done, because the prot...
Scratch no more: Gene for itch sensation discovered
...of Medicine in St. Louis have identified the first gene
for the itch sensation in the central nervous syst...Ph.D., found that laboratory mice that lacked this gene
scratched much less than their normal cage-mates when given itchy stimuli. The laboratory experimen...
Researchers watch antibiotics, bacteria meet at atomic level
...A polymerase is the enzyme responsible for setting gene
expression in motion, a process called transcription. Without a properly functioning RNA polymerase, a cell will die. RNA polymerase spends most of its working hours as the elongation complex, Artsimovitch said. The complex makes RNA's messages one...
News tips from the Journal of Neuroscience
...VMAT is a member of the toxin-extruding antiporter gene
family with the interesting acronym TEXAN. Accordingly, Caudle et al. examined whether reduced VMAT2 leads to degeneration of dopamine neurons. The authors examined mice that expressed 5% of the normal protein (VMAT2 LO). These mice showed elevated r...
Drug protects brain cells in Huntington's disease model, researchers find
... dominant gene, meaning that a person carrying the gene
is certain to develop the disease and has a 50 per...e genetically engineered to carry the mutant human gene
for Huntingtons, causing symptoms and death of brain cells similar to those seen in the disease. The...
Fruit fly gene from 'out of nowhere' is discovered
...g genes, but Cornell researchers have discovered a gene
in some fruit flies that appears to be unrelated t...cestor. And early evidence indicates that the new gene
is functional (as opposed to being nonfunctional "junk" DNA) and is likely to express a protein invo...
Effects of aging in stem cells
...s underlying aging of stem cells by looking at the gene
expression profiles of aging hematopoietic stem ce...ive with age, while genes important for regulating gene
expression and genomic integrity became less active. These results lend strong support to the notion...
...ort on their discovery that mutations in the mouse gene
encoding PPAR adversely affect lactation milk quality, and have serious health consequences for nursing pups. By examining PPAR functions in vivo, our work reveals an unexpected link between diet, inflammation and the quality of mothers milk, exp...
A novel molecular dictator 'with a conscience' discovered
...with a conscience. "The dictator is a specific gene
suppressor called YY1, which has the therapeutically appealing capacity to differentiate between certain cell types when it goes about its activity," says Professor Khachigian. This key finding has just been published in the world's premier cardio...
Identified main genetic variants involved in response to HIV
...control of viral infection. Results point to two gene
variants related to the immune system. More precis...ed in immune damage of patients, particularly in a gene
encoding a protein which seemingly participates in viral replication, and is also located in chromos...
One species, many genomes
...ies, or cannot be found at all. Almost every tenth gene
was so defective that it could not fulfill its nor...uences. "That even in a minimal genome every tenth gene
is dispensable, has been a great surprise," admits Weigel. Detailed analyses showed that genes for...
Genomic analysis uncovers new targets for HIV vaccine
...rnational team of researchers has identified three gene
variants in the DNA of 486 people infected with HI...cines. In the new analysis, patients with specific gene
variants in key immune system cells appear to be much better at controlling the proliferation of the...
New clue into how diet and exercise enhance longevity
... found that knocking out both copies of the Irs2 gene
in mice reduces brain growth and produces diabetes... they knocked out one or both copies of the Irs2 gene
only in the brains of mice. Mice lacking one copy of the Irs2 gene
in brain cells also showed an ...
First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
...orm this study. The investigators identified three gene
variants, two of which are linked to an infected p... after infection. If scientists could pinpoint the gene
variants that help some people control HIV infection--or avoid it altogether--they might be able to ...
Probing biology's dark matter
... look for variations in the sequence of a specific gene
found in all microorganisms; another is a complete...ups of TM7 bacteria might use to get around, and a gene
shared with bacteria known to cause chronic inflammation. Just as importantly, the researchers sa...
New proteomics research promises to revolutionize biomedical discovery
...uman proteins known to exert specific functions in gene
transcription and RNA processing, the Coulombe team has defined an intricate network of 805 high-confidence interactions that connect together 436 different proteins. Among them, many proteins of previously unknown function can now be inferred putati...
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