Low dose radiation evades cancer cells' protective 'radar'
...istakes or mutations that are passed down to other generations of cells," explains DeWeese, chairman of the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins. "A dead cell is better than a mutant cell, so if the damage is mild, cells die instead of risking repair." Higher doses o...Laboratory test of evolutionary theory confirms importance of links between populations
...By working with microbes that go through about ten generations per day in the laboratory, we were able to track evolutionary changes through time and answer questions that previously had only been addressed theoretically," said Samantha Forde, a postdoctoral researcher at the University of California, Santa Cruz...Mitochondrial mutation linked to blood pressure and cholesterol problems
...e possible by the evaluation of 142 people in four generations of an affected family. Although family members with each disorder hypertension, hypercholesterolemia and hypermagnesemia have the same mitochondrial mutation, the presence of the mutation does not produce all of the symptoms in each individual. ...Growth factors confer immortality to sperm-generating stem cells
...t is possible to modify the male germ line between generations by manipulating the spermatogonial stem cells in culture. "If each parent in a couple carries a similar defective recessive gene for a disease, for example, it should be possible in the future to harvest the male's spermatogenic stem cells, correct...New Royal Society journal studies
...to mouse and notably are repetitively used for all generations of teeth, from the mouth margins to rear gill arches. Thus a molecular tool kit for making teeth emerged early in vertebrate evolution. Contact: Professor Moya Smith, Craniofacial Development, United Dental & Medical Schools, Guys and St. Thomas Hosp...UCSD researchers find effective treatment for unusual fever syndrom caused by cold exposure
... of FCAS that had caused kidney failure in several generations of her family. Since she began injections of anakinra every other day, her symptoms have disappeared, her kidneys are working normally, and Furst says she's never felt better. "My quality of life has had such dramatic improvement that I f...World's largest population study on BRCA1/2
...eople. Nearly 948,000 families with at least three generations were classified according to the clinical criteria proposed by the German Consortium for Hereditary Breast and Ovarian Cancer for testing of BRCA1/2 mutations. The researchers Dr Justo Lorenzo Bermejo and Professor Kari Hemminki compared the cance...Genome of ancient fish could reveal evolutionary mysteries, Stanford scientists say
...oung. This means that the coelacanth has had fewer generations of offspring to accumulate mutations. The fact that coelacanth is available for sequencing is a lucky accident. They were thought to be extinct until 1938 when museum curator Marjorie Courtaney-Latimer discovered a specimen in a fisherman...Discovery of real-time natural gas formation offers prospect for renewable energy resource
...hat could lead to a renewable source of energy for generations to come. The company today announced that laboratory evidence shows that the Powder River Basin (PRB) coals are generating natural gas in real time through the ongoing activity of anaerobic microbes (bacteria that live in the absence of oxygen) resid...Studies in Royal Society journals include stress in birds and depletion of medieval fish stocks
...2 mutants, actually became extinct after only four generations in the presence of normal worms. It seems longevity does come at a cost, just as predicted by evolutionary theories of aging. This finding may have implications for future interventions in human aging. Contact: Dr NL Jenkins, Buck Insitute fo Age R...Study in Royal Society journal on possible genetic factors in social responsiblity
...to mouse and notably are repetitively used for all generations of teeth, from the mouth margins to rear gill arches. Thus a molecular tool kit for making teeth emerged early in vertebrate evolution. Contact: Dr Isabelle Cote, School of Biological Sciences, University of East Anglia, Centre ...New drug sidesteps Gleevec resistance in human trials
...ed as a "molecularly targeted" inhibitor, the next generations of Gleevec, of which BMS-354825 is is one, are being refined and improved by structural biology studies that show how the drugs "fit" with their target, and how mutations alter the shape of that target. In this case, the drug's target is the Abelson ...NC State gets $1.59M grant to map genome of parasitic worm
... and re-infect the roots. So you can have multiple generations infecting plants in one season," Opperman says. Above ground, infected plants will show stunted growth or become yellowed or wilted. The root-knot nematode does not discriminate, infecting peanuts, tomatoes and soybeans, just to name a few widely gr...Inexpensive, mass-produced genes at core of synthetic biology advances at UH
...o not occur naturally, but that are needed for new generations of vaccines and therapeutic agents, including vaccines for HIV and other viral diseases. This technology also will facilitate development of new medications through the creation of humanized yet synthetic antibodies that could be especially useful i...Novel asthma study shows multiple genetic input required; single-gene solution shot down
...ely to be lost as breeding proceeds." After seven generations of this selective breeding, Ackerman et al. found that several regions derived from the hyperresponsive A/J mouse strain were retained in mice with elevated AHR. Contrary to expectations, they found "no apparent association between inheritance of any...Born to run? Capacity for aerobic exercise linked to risk of heart disease
...chool. The rats in the study are the product of 11 generations of artificial selection for exercise capacity cond...oal in selecting and breeding these rats over many generations was to concentrate genetic differences related to exercise capacity," says Britton, a U-M professor ...HHMI professor, 138 undergraduates identify essential genes in eye formation
... a series of five crosses or matings of successive generations of flies, the students created flies with homozygous lethal mutations in the eye, independently marked by eye color. The use of flippase for mitotic recombination is a standard technique, used by Drosophila geneticists to study the impact of mutation...Charles Yanofsky named National Medal of Science winner
... career at Stanford, Yanofsky has mentored several generations of graduate students and postdoctoral fellows, dozens of whom have become leading researchers in academia and the biotechnology industry. A scientific education Born in New York City in 1925, Yanofsky was one of the early graduates of the Bronx Hig...Fitness correlates of song repertoire size in free-living song sparrows
...ve more descendants in both current and subsequent generations by pairing with males with large song repertoires....Map of human genetic variation across populations may promise improved disease treatments
...together are far less likely to be reshuffled over generations by the biological process known as recombination. As a result, certain patterns of variation, or "haplotypes," have been preserved across human history. The presence of these patterns, known as "linkage disequilibrium," allowed the Science authors ...