Intracellular protein localization involved in new tumor progression pathway
...d laboratory technique to test for cells that lack growth control and are potentially tumor forming. In mice...ting of survivin, this resulted in increased tumor growth and eleimination of apoptosis. The data here demon-strate a novel pathway for apoptosis inhibition a...Antibiotic identified as potential anti-cancer candidate
...ive effect on human cancer cell lines and on tumor growth in a mouse model. They theorized this growth inhibitory activity might be related to actinonin's inhibition of human Pdf. The researchers now pr...S1P1 essential for tumor growth and is blocked by RNA interference
Tumor growth and metastasis require new blood ves-sel growth, a...is. There are many factors involved in the nor-mal growth and stabilization of new blood vessels. One of these, sphingosine 1-phosphate receptor 1 (S1P1), is ...Normal cells in tumors may aid cancer growth
... growth. However, stromal cells can produce growth factors and other substances that can influence th...omal cells may also produce factors that limit the growth of nearby cells. Loss of genes for such factors would remove those inhibitors and allow cancer cells...Horse auction raises $75,000 for research
...ove the reproductive efficiency of mares, optimize growth in the young horses, enhance athletic performance, and protect and improve the land and waters. In addition, research projects are being conducted that utilize the horse as a model for insulin resistance and skeletal development in ways that may prov...UCSD medical researchers use brain cell transplants to correct muscle spasms after aneurysm surgery
...A post-mortem study of the animals showed a robust growth of neurons and an increase in neurotransmitters in the spinal cords of rats that received the transplanted neuronal cells. "These findings provide conclusive evidence that transplantation of well defined human neuronal cells into a specific region of...An old adage about apples finds scientific backing
... apoptosis, a critical step in halting cancer cell growth and spread. "This part of the study helped... mechanism by which procyanidins might prevent the growth of cancer cells," said Dr. Raul.To determine if procyanidins exerted any chemopreventive activity in...New version of tumor-suppressor linked to progression of childhood cancer
...ne kinase receptor type I (TrkA) responds to nerve growth factor and plays a key role in the development of the nervous system. Mutated TrkA has been associated with many human cancers, including colon, thyroid and prostate cancers. However, previous studies have suggested that TrkA acts as a tumor-suppress...Manipulation of epigenome turns off as many genes as it turns on
...to selectively "restart" genes that limit cancer's growth -- a potential treatment option already in early c...e, in cancer cells genes that normally stifle cell growth -- so-called tumor suppressor genes -- are shut down because extra methyl groups are hanging on to t...To save dolphin's dorsal fin experts combine medical technology and teamwork
... emitting diode (LED ) therapy to stimulate tissue growth and regeneration in his injured fin. Liko sustained a tear at the base of his dorsal (top) fin, likely in a game of "chase" with his dolphin cohorts. While wild dolphins have been observed with similar and more severe lacerations that can result in ...Other highlights in the October 20 JNCI
...eatment of NonSmall-Cell Lung Cancer Insulin-like growth factor binding protein 3 (IGFBP-3)--a natural inhibitor of lung cancer cell survival and growth--is frequently decreased in lung cancers, a trait associated with poor prognosis and survival. A potential obstacle to treating lung cancer patients with ...Stony Brook University medical researcher developing new medication to prevent colon cancer
... potent than traditional aspirin in inhibiting the growth of colon cancer cells and quite effective in preve...chnique called magnifying endoscopy to examine the growth of the earliest recognizable lesions, known as aberrant crypt foci, or ACF. The imaging technique wi...Neurosurgeons looking at stem cells from skin to fight brain tumors
...ed both increased blood supply and decreased tumor growth into the surrounding brain. These mice also lived on average 50 percent longer than mice that weren't given this therapy. The annual meeting provides continuing medical education for practicing neurosurgeons, neurosurgical residents in training, a...Early life stress can inhibit development of brain-cell communication zones, UCI study finds
...ress, the neuropeptide CRH, can inhibit the normal growth of dendrites, which are branch-like protrusions of...orly. In turn, the group found exuberant dendritic growth in hippocampus tissue in which CRH could not exert any effect because the CRH receptor was eliminate...Study is looking at ways to help stroke survivors regain lost motor skills
...face of the brain, in hopes of "jump starting" the growth of new nerve fibers, or retraining a new area of t...help in one of two ways either by stimulating the growth of new nerve fibers in the area of the brain affected by stroke, or by helping enable other areas of...Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
...tion, and cell differentiation. One member of this growth factor group, Fgf8, has key functions during the d...ve signaling range. These new results suggest that growth factors are able to spread extracellularly by a diffusion-based mechanism. An especially important i...Singled out: Spotting mutant neurons in normal brains offers clues to Fragile X
...gile X Syndrome may be caused by alteration in the growth of the brain's nerve cells and the neuronal connectivity between these cells....Sandbagging cancer in the bloodstream
...f one another during events like angiogenesis--the growth of new blood vessels that often accompanies tumor ...ls secrete a protein known as vascular endothelial growth factor (VEGF). VEGF stimulates a protein called Src kinase, which causes proteins known as cadherins...Potential new oncogene may be missing link in cancer-causing chain
..., a key cell signaling pathway that regulates cell growth and development is overactive because a gene coding for a pathway component has mutated," Bu says. Increased signal activity from this pathway can lead to abnormal cell proliferation and ultimately to cancer, but researchers have been unable to iden...