Study begins to reveal clues to the cause and progression of sepsis
...found that 82 percent of the participants with CAP had elevated cytokine levels. Levels were highest when...zation even after the clinical signs of infection had subsided. Levels were highest in those with fatal severe sepsis, lowest in those with CAP but no sep...Features of replication suggest viruses have common themes, vulnerabilities
...erules observed by Ahlquist and his colleagues all had narrow necks that transcended the membrane of the organelle to the cytoplasm, the medium inside the cell and in which the organelle is suspended. The neck is a gateway that appears to permit substrates needed for replication to enter and newly made v...Gene regulation, not just genes, is what sets humans apart
...rm, but the coding regions of neural-related genes had shown very little sign of positive selection in th... chimps were 99 percent the same genetically, they had offered the suggestion that greater differences might be found in the regulatory regions. The type...Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
... designed to see if green tea catechin concentrate had any effect on the levels of GST enzymes in healthy...ll participants were included for analysis. But it had its most significant effect in volunteers whose baseline blood measurements showed low GST activity ...High blood pressure, low energy -- a recipe for heart failure
...me heart cells died. They also saw that the hearts had depleted fuel reserves. Kelly indicates that these studies show for the first time that changes in the ability of the heart to produce energy lead to heart failure in some cases. "ERR and some of its partners in the cell are a little like puppeteers...Swarming starlings help probe plasma, crowds and stock market
...behaviour of birds and insects. Professor Viscek had devised a simple model to replicate the flocking b...ons and mutual dependencies between companies that had no obvious connection yet seem to share similar movements in share price. ...Smokeless tobacco more effective than cigarettes for delivering dangerous carcinogens into the body
...ticipants included men and women aged 17 to 80 who had sought but had yet to begin treatment for tobacco addiction, and who used conventional, popular U.S. brands of smo...No evidence that widely prescribed statins protect against prostate cancer
...tudies on statin use and prostate cancer risk have had mixed results, according to Hall. To study a narrow question − whether statin use reduces androgen concentrations in the blood − the researchers examined data from the Boston Area Community Health (BACH) survey, a population-based, NIH...Antioxidant overload may underlie a heritable human disease
...ilar deleterious effects. Indeed, reductive stress had been demonstrated in simpler organisms but not in ...oteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious. The r...Evolution is driven by gene regulation
...ind that even the closely related species of yeast had extensively differing patterns of regulation. In...d, we were able to see functional differences that had been invisible to researchers before, said Snyder. We expect that this approach will get us closer t...Research shows skeleton to be endocrine organ
...preciated until now. Karsenty and his colleagues had previously shown that leptin, a hormone released b...e lacking the osteocalcin protein showed that they had type 2 diabetes, increased fat mass, a decrease in insulin and adiponectin expression, and decreased...New molecular regulators of hyperthyroidism and goiter
...iter. Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein co...G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In ...JCI table of contents: Aug. 9, 2007
...iter. Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein co...G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In ...Proteaceae spread by continental drift and transoceanic dispersal
...when I met up with Frank Rutschmann in Zurich, who had the expertise on molecular dating, and Herv Sauquet, a postdoc at the Royal Botanic Gardens, Kew, United Kingdom with an extensive knowledge of the fossil record of the Proteaceae, that it became possible to undertake this rigorous analysis. Sometime...Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
... the ovx rats, those that did not receive estrogen had significantly higher blood pressure than the contr....2 versus 110.6 mmHg). The rats receiving estrogen had the lowest blood pressure levels of all (102.6 mmHg). The researchers also noted that the rats wh......onventional grain ethanol plants, but that neither had a significant cost advantage over the other. Comparing the costs of biofuels is complicated by the fact that most studies rarely employ the same bases for economic evaluations. Differences in assumed plant size, biomass costs, method of project fin...Sugar and spice and everything nice: Health differences in newborn girls and boys
...e researchers found that the newborn female hearts had accumulated a significant 47 percent greater H+ level within 60 minutes of ischemia. This was associated with a significant 13 percent greater accumulation of lactate. They also found the CP reserve was 22 percent lower than baseline compared to male...Weizmann Institute scientists discover a control mechanism for metastasis
... received these drugs, the harmful 'plug' proteins had disappeared from the cancer cells. Prof. Yarden: 'The mechanism we identified is clinically important. It can predict the development of metastasis and possibly how the cancer will respond to treatment.' This discovery may, in the future, aid in the ...Inflammation may cause preterm labor and fetal deaths
...tum was injected into three groups of miceone that had TLR4 receptors, a group of TLR4-deficient mice and a group that had TLR4 receptors but were given a synthetic compound to block the receptors inflammatory response. Wit......ircumpolar Current, but seals from other locations had a very different strategy, and visited colder waters nearer the continental shelf. He added, This approach helps us to understand current population trends, where the animals forage and predict the availability of food under various climate change ...