Nicotine rush hinges on sugar in neurons
... inside is a long-standing one. Some researchers had suggested that when a chemical such as nicotine bi...orce of protein crystallography. Homologs of nAChR had been studied at the atomic scale, but not the receptor itself....A novel molecular dictator 'with a conscience' discovered
... growth of good cells as well as the bad. If you had to have catheter intervention to re-open an occluded artery, for sustained symptom-free benefit you would be hoping for suppressed smooth muscle cell growth, without affecting endothelial cell growth, says Professor Khachigian. And thats exactly w...Identified main genetic variants involved in response to HIV
...d AIDS of Hospital Clnic-IDIBAPS of Barcelona, and had the collaboration of Hospital de la Santa Creu i Sant Pau, and Hospital Mtua de Terrassa. Research has been conducted with the latest genomics and bioinformatics technologies, analysing 550,000 variations of the complete human genome in 486 patient...Pediatric ritalin use may affect developing brain, new study suggests
..."One thing to remember is that these young animals had normal, healthy brains," she says. "In ADHD-affect...iving Ritalin, the animals' neurochemistry largely had resolved back to the pre-treatment state. "That's encouraging, and supports the notion that this ...'Preconditioning' helps protect brain's blood vessels from stroke
...- the preconditioning method used in this study -- had a 68 percent reduction in stroke intensity, the re... at a nearly normal level. That's something no one had shown before." He stressed that it's far too dangerous to give patients peroxynitrite, so the goal...Rise of dinosaurs in Late Triassic more gradual than once thought
...) was discovered in Poland, no dinosaur precursors had been found from the Late Triassic either. At the Hayden Quarry, Irmis and Nesbitt found both early dinosaurs and dinosaur precursors, not to mention bones of crocodile ancestors, fish and amphibians, all dating between 220 and 210 million years ago...Genomic analysis uncovers new targets for HIV vaccine
...I investigators wanted to study those patients who had many sequential blood samples taken during this pl... data collected from more than 30,000 patients who had blood samples taken as a part of nine studies in Europe and Australia. They arrived at 486 patients ...New clue into how diet and exercise enhance longevity
...ulin receptor substrates (Irs). Other researchers had shown that reducing the activity of the pathway in...atic beta cells. In earlier work, the researchers had found that knocking out both copies of the Irs2 gene in mice reduces brain growth and produces dia...Molecular detectors may refine cancer treatment
... UF Shands Cancer Center. At present, doctors have had only their experience to rely upon to determine the best treatment for these patients. Our findings will give doctors an effective tool to more precisely make a diagnosis and to tailor treatments. UF researchers built designer probes using cancer c...First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
...ool genetic data from HIV-positive individuals who had enrolled in nine studies based throughout Europe a...86 HIV-positive people whose viral load set points had been carefully and accurately measured at multiple time points--for the genome-wide association stud......ied group of bacteria. Most TM7 genes, they found, had remarkably little similarity to genes in known bacterial groups. But some of the genes hinted at interesting aspects of the organisms biology, such as an unusual gliding motion that groups of TM7 bacteria might use to get around, and a gene shared wi...JCI table of contents: July 19, 2007
...irth. Embryonic hearts containing the mutated SHP2 had altered cardiomyocyte cell cycling and structural ... of the mutant protein in postnatal cardiomyocytes had no effect. Fetal expression of this mutated protein was found to activate the ERK1/2 pathway and fur...Genetic diversity in honeybee colonies boosts productivity
...nd of the summer, the genetically diverse colonies had five times more bees, eight times more reproductiv...se differences are noteworthy considering colonies had similarly sized worker populations when they were first formed," said Mattila. "Undoubtedly, our res...Obesity found to be a risk factor for multiple myeloma
...ng overweight or obese women, yet those women also had an increased risk. The study also looked at whether regular exercise is related to risk of multiple myeloma. There was not a clear effect of exercise on risk, although the results among women suggested that those who exercise more might have a lo...Scientists a step closer to understanding how anaesthetics work in the brain
...tant anaesthetic targets. However, until now, weve had no direct way to test this idea. Because a single mutation can block the effects of anaesthetics on this potassium channel without affecting it in any other way, it could be introduced into mice to see if they also become insensitive to anaesthetics....A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
...cells transplant in rabbits, which previously have had an epithelial corneal lesion induced, causing loss..., with induced limbic insufficiency and which then had a transplant of adult stem cells, showed recovery of the corneal epithelium in 60% of the treated an...MIT IDs link between brain tumor proteins
...ts with drugs that inhibit EGFRvIII, but they have had little effect. This could be because the continuou...urned off in most adult cells. Until now, there had been no evidence of any cross-talk between c-Met and EGFRvIII in GBM. This discovery could offer an ...New proteomics research promises to revolutionize biomedical discovery
...zyme was recognized for more than a decade, but it had been so far impossible to isolate it in the sea of proteins that make up human cells and further characterize it. We succeeded in finding the enzyme, which we named MePCE, as an interaction partner of another cellular protein it regulates. Many other...Exercise, exercise, rest, repeat -- how a break can help your workout
...e physically active and familiar with exercise and had them perform three separate trials: one single...an did the Single trial. This Repeated trial also had a pronounced increase in free fatty acids and glycerol (chemical compounds that are released when st...... that showed the smallest lag in escape times also had higher levels of ∆FosB in a brain region involved in processing of pain signals and defensive responses. In contrast, animals with either longer escape lag times or failure to escape showed lower ∆FosB levels. What's more, when the rese...