Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
...to restore the brakes on runaway cell division and halt the progression of cancer. First, the scientists mapped the network of genes that is activated in normal cells upon receiving the order to divide. The "divide!" signal comes from outside the cell in the form of a chemical called a growth factor, an...New therapeutic target for Alzheimer's could lead to drugs without side effects
...s therapy based on these chemicals could reduce or halt beta-amyloid build-up without causing side effects. "Numerous efforts have been directed at the development of drugs that inhibit gamma-secretase," says Greengard, "but there have been significant side effects in animal studies. Our hope is that this......ation of genetic science and psychology to try and halt the alarming rise in skin cancers. Their main focus of the researchers is collecting DNA from thousands of people, to identify the genes running in families or populations which may increase susceptibility to skin cancer. The project coordinator ...Prion disease treatable if caught early
... intervention in human prion disease will not only halt clinical progression but allow reversal of early behavioral and cognitive abnormalities," wrote the scientists....Scientists find potential 'off-switch' for HIV virus
...of full-blown infection. Mechanisms do exist to halt the process, however. For example, another enzyme within the affected cell called SirT1 is capable of pulling the chemical tail off the Tat protein, rendering it silent. The interplay between p300 and SirT1 comprises the resistor and can effectively ...Wheat can fatally starve insect predators
...vehicles to carry lectin or a toxin into plants to halt the virulent insects, Williams said. The regulatory regions, or promoters, would be from genes that the fly larvae ordinarily manipulate so plants will produce useful nutrients for the insect. Instead, the promoter would be hooked up to a lectin or t...Jefferson scientists find guardian gene's choices crucial to stopping cancer process
...ged cell from becoming cancer. The gene can either halt the cell's growth or send it spiraling toward certain death. How this choice is made, the researchers say, could have implications for future strategies in chemotherapy drug development. According to Steven McMahon, Ph.D., associate professor of ca...... protein. Some proteins can activate a "switch" to halt their own synthesis once they are present in sufficient quantity. This is because the mRNA does not only contain the genetic code for the protein but can also contain segments with a switching function. The protein or a closely connected metabolite b...SNM takes action to alter DRA provision for imaging payment caps
...n and is working as a member of AMIC to reverse or halt this implementation until the full impact of the cuts can be determined, he indicated. Under DRA, reimbursement for Medicare beneficiaries who use outpatient imaging services at centers not affiliated with hospitals will be linked to HOPPS rather t...Growth factor signals influence balance between normal growth and cancerous growth
...e body's tissues. When the authors used genes to halt IGFBP-2 production by prostate cancer cells in culture, they found that p53 lost its ability to block IGF-I from activating one of its major signaling targets in those cells. IGF-I is important because, along with naturally produced human growth ho......is guarantees that the cells are only brought to a halt where they are to fulfill their biological function. These processes are of great relevance to medicine. For example, red blood corpuscles infected with malaria stick to blood vessel walls to escape destruction in the spleen and patrolling white bl...UGA scientists unravel 'molecular inch-worm' structure of walking-pneumonia bacterium
...ing a way to stop such attachment or gliding could halt infections or make them far less severe. "M. pneumoniae accounts for 20 percent of community-acquired pneumonias in this country," said Krause. "Finding out more about how the bacterium that causes the disease works gives us a new edge in thinking ...Researchers receive $12.8 million NIH grant to improve diagnosis/treatment of chronic lung disease
...cause they may help develop approaches not only to halt fibrosis but maybe even to reverse it....New study aims to stop sepsis in its tracks
...dy to determine whether specific interventions can halt the progression to severe sepsis and septic shock. Key to the project is determining whether there are "golden hours" during which prompt, rigorous, standardized care can save patients' lives. The project may establish the first set of standard pro...New angiogenesis finding may help fight cancer growth
... vessels, or angiogenesis. The finding may help halt tumor growth in cancer patients, says Emery Bresni... blocking angiogenesis could be a promising way to halt tumor growth. Also in June, the FDA approved a compound that inhibits VEGF for treating colon cancer...UGA scientists engineer root-knot nematode resistance
.... Hussey and his research team have found a way to halt the damage caused by one of the world's most destructive groups of plant pathogens. Root-knot nematodes are the most economically important group of plant-parasitic nematodes worldwide, said Hussey, a distinguished research professor in plant pathol...Calorie restriction in non-human primates may prevent and reduce Alzheimer's disease neuropathology
... research that experimental dietary regimens might halt or even reverse symptoms of Alzheimer's Disease (AD). The study entitled "Calorie Restriction Attenuates Alzheimer's Disease Type Brain Amyloidosis in Squirrel Monkeys" which has been accepted for publication and will be published in the November 200...Distinguishing friend from foe in the battle against cancer
...nical trials has been combined with other drugs to halt cancer cell growth. But to cancer cells, rapamycin is both friend and foe. "Rapamycin is not as successful as initially expected in treating cancer," explains Ghosh. "Instead of killing cells, you end up triggering a survival response in them." Thi...Research partnership to protect the Coorong
...A number of management initiatives are underway to halt and reverse the degradation of the Coorong, such as the Murray-Darling Basin Commission's "Living Murray Initiative". However, planning remediation action is currently hampered by limited understanding of the relationships between the water and salin...Study provides first-ever look at combined causes of North Atlantic and Arctic Ocean freshening
... freshwater flow to the Arctic Ocean could slow or halt the Atlantic Deep Water formation, a driving factor behind the great "conveyor belt" current that is responsible for redistributing salt and thermal energy around the globe, influencing the planet's climate. One of the potential effects of altered gl...