Multiple sclerosis progression linked to immune-cell substance
...ly, perhaps this study will lead to drugs that can halt the course of MS by blocking the action of MIF." MS is an inflammatory, autoimmune disease which primarily affects the brain and spinal cord. Autoimmune diseases occur when the body's own immune cells destroy tissues in the body. In MS, immune cells...Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
...cle that determines if the cell should temporarily halt its march toward division, allowing more time for the damage to be repaired. This checkpoint can be activated if a cell's genetic material is damaged or if mistakes were made when DNA was replicated. A less efficient checkpoint, however, would not c...Double-trouble: Cells with duplicate genomes can trigger tumors
...omosomes - an error that does occur randomly will halt cell division and produce tetraploid cells. Together, these papers lend experimental support to Boveri's ideas that errors in cell division contribute to the development of cancer....Shorter colds, milder flu may follow from newly revealed immune mechanism
...o ultimately clear the viral debris and so finally halt the infection. Balancing these cell death and survival pathways can determine whether the virus or the host wins the battle." Next, the researchers will look further at precisely how CCL5 prevents cell death. "In this initial study, we identified the...Antibody to a naturally-occurring sugar chain in colon inhibits inflammatory bowel disease
...able to reverse early symptoms of inflammation and halt further progress of disease," said Srikrishna. The antibody also reduced the accumulation of white blood cells armed to fight disease and inhibited the expression of cellular messengers (cytokines) typically seen in inflammation. "Ther...Purdue scientists treat cancer with RNA nanotechnology
...ds of RNA inside with them, where they are able to halt viral growth or cancer's progress. The team has already tested the nanoparticles successfully against cancer growth in mice and lab-grown human cells. "RNA has immense promise as a therapeutic agent against cancer, but until now we have not had an ef...University of Kentucky awarded $6 million for GDNF and related research
...therapies in that it has demonstrated potential to halt or perhaps reverse the neurodegenerative condition. Current treatments only provide temporary relief from symptoms. "The NINDS is pleased to continue the support of the University of Kentucky Udall Center, a unique component of the Udall center progr...Emerald Spectre haunts Ontario's ash forests
...n to stop the borer's spread have so far failed to halt its outward march. At risk are nine billion ash trees in the United States and Ontario, with an estimated value of more than $300 billion in the United States alone. "Its distribution continued to spread during 2005 in the Great Lakes region despite ...Markers of brain cell development may help success of stem cell transplants
...ntially harmful cells during brain development, to halt unwanted proliferation of transplanted stem cells. Dr. Yu hopes the new developmental markers will help with the other problem. "There are other players, but these are important factors that help the brain form. I think it's a good start. Now that we...Casting a wide net to fight coronaviruses
...be able to block the protease's activity and maybe halt viral replication. The authors designed a synthetic inhibitor that bound strongly to the protease and used it as a base to design a panel of inhibitors, which allowed them to identify compounds that rapidly blocked proteases from multiple coronavirus...Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
...to the action plan, a series of programs needed to halt declines in ape populations will cost just under $30 million. The measures include anti-poaching activities, improved monitoring and response to Ebola outbreaks, increased training, and tourism development. "As dire as the threats are to the surviv...USC researchers find drug is tough tumor fighter
..., the scientists showed that the analog manages to halt tumor growth even in drug-resistant lines of multiple myeloma cells. (Multiple myeloma is an incurable cancer of the plasma cell; plasma cells are components of the blood, and play a key role in the body's immune response.) The work was published in...New role for gene that counteracts formation of tumors
...lso trigger programmed cell death. Because p53 can halt the further growth of cells, this protein plays an essential role in suppressing the development of tumors and blocking the onset of cancer. When cancer appears, the p53 protein is deactivated - either through an alteration or mutation in the gene it...One bacteria stops another on contact
...may eventually lead to new antimicrobial agents to halt bacterial growth which would be an entirely new system to shut bacteria down, according to the scientists. "This has potential implications for new antibiotics," said Low. "If bacteria can do this, then maybe we can do it." Doctoral student and firs...Type 2 diabetes: Problems in the furnace
...pidly worldwide, and effective drugs are needed to halt or even reverse the disease process. Understanding how the cell's internal energy system is controlled by the hormone, insulin, and how the mitochondria behave, may eventually lead to improved ways to overcome or prevent diabetes....Stem cells bring fast direct improvement, without differentiation, in acute renal failure
... MSC paracrine effects prompt a positive cascade, halt inflammatory response Rather, the Utah team found that "administered stem cells don't stay in the kidney that has ARF long enough to differentiate into kidney cells, but rather appear to alter the course of ARF by a number of identifiable and some ...Scientists discover genetic pathway responsible for breast cancer cell growth
...estrogen and one in particular that can be used to halt the growth of breast cancer cells. The study, publ...ck the growth-inducing effect of estogen, and thus halt the growth of breast cancer cells," says Dr. Gigure. In FOXA1 researchers have found a new target th...DDT-resistant insects have additional genetic advantage that helps resistance spread
... certain antibiotics from being prescribed may not halt the spread of antibiotic resistance in bacteria. "We found that DDT resistance in fruit flies not only carries no cost but in fact confers an advantage when inherited through the female," said Richard ffrench-Constant (correct), from the University o...Smoking gun for Alzheimer's disease
...ght be able to be used on Alzheimer's patients, to halt the disease progressing. At present, there are only minimally effective treatments for the condition, which is increasing with the ageing population. "We found that all of the brains of dementia patients showed quinolinic acid neurotoxicity," said Pr...New understanding of cell movement may yield ways to brake cancer's spread
...ellular migration can help develop treatments that halt cancer metastasis and immune disorders like arthritis and asthma. "Previous studies by us and others have identified how a migrating cell 'gets its wheels' and, mechanistically, is able to move. In this study, we have now determined how these wheels...