Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
...children and the elderly. There is no treatment to halt its progression, which leads to death after 10 to 25 years. In the United States, the prevalence of the disease is about 10 cases per 100,000 people, or about 35,000 people in all, with another 150,000 individuals at risk. Each child of a parent wit...Understanding natural killers could lead to new hepatitis treatments
...ssel walls, even upstream against blood flow. They halt only when they receive a chemical signal to unleash an immune-system assault on marauding microbes, other invaders or damaged tissue. The findings offer a new way of thinking about this important class of immune cell, which is responsible for the inf...Institute for Medical Research scientists identify gene critical to type 1 diabetes
...rediabetic individuals, blocking the protein would halt the harmful immune process and leave the remaining beta cells intact and able to produce insulin. "While it's very likely that multiple genes are involved, our findings provide evidence that blocking this particular protein is a promising approach fo...Study identifies mechanism of resistance to targeted therapy in lung cancer patients
... for the epidermal growth factor protein (EGFR) to halt the spread of cancer cells. In 2003, it was approved by the U.S. Food and Drug Administration as a treatment for NSCLC. Clinical applications of the new drug initially yielded very good results, with approximately 10 percent of patients experiencin...Why some lung cancers stop responding to Tarceva and Iressa
...nib are so-called targeted therapies, in that they halt the growth of certain cancers by zeroing in on a signaling molecule critical to the survival of those cancer cells. The two drugs are effective in about 10 percent of US patients with non-small cell lung cancer (NSCLC). Previous work from this group ...Stockpile bird flu vaccine now
...r says. "It could be H7 or H9." But the failure to halt the H5N1 bird flu outbreaks in Asia, and the growing number of human cases (see Table), is changing minds. Recent findings also suggest that a stockpiled vaccine could provide some protection even if it does not exactly match the pandemic virus. Exp...Findings suggests that blocking estrogen may be crucial to lung cancer survival
... therapies that target specific pathways and put a halt to estrogen signaling," said Dr. Siegfried. The studies were funded by a Specialized Program of Research Excellence (SPORE) award in lung cancer from the National Cancer Institute to the University of Pittsburgh Cancer Institute. Co-investigators on...Gene therapy for Parkinson's disease moves forward in animals
...euroscience, essentially describes one strategy to halt Parkinson's disease at its onset and another strategy to treat the devastating side effects that occur when treating the disease in its later stages. By inserting corrective genes into the brain, scientists studying small monkeys called marmosets pr...Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
... days. "We thought that clearing the plaques would halt the progression of the damage--stop the development of new swellings," says Brendza. "But what we saw was much more striking: in just three days, there were 20 to 25 percent reductions in the number or size of the existing swellings." The nerve cells...NSBRI news: Bone-quality assessment tool for space and Earth
...is for injuries or conditions that might otherwise halt a mission. "Aside from use inflight, my goal is to make this device available to physicians across disciplines to improve the diagnosis of osteopenia and osteoporosis," Qin said. "Because such diseases are essentially painless at the initial stages,...UT Southwestern researchers locate gene family involved in determining potential for acquiring lupus
...Wakeland and his colleagues of four genes that can halt lupus. These "suppressor" genes Sles1, Sles2, Sles3 and Sles4 can block the disease even if the susceptibilitygene family is active. "For example, Sles1 specifically suppresses the autoimmune activity associated with the SLAM/CD2 gene ...Vitamin E in plant seeds could halt prostate, lung cancer, says Purdue scientist
... most manufactured nutritional supplements - might halt the growth of prostate and lung cancer cells, according to a Purdue University study. A team led by Qing Jiang (pronounced "ching zhang") has found that gamma-tocopherol, which occurs naturally in walnuts, pecans, sesame seeds, and in corn and sesame...Horwitz Prize to be shared by Tony Hunter, Anthony Pawson
...and between cells have led to drug therapies that halt the spread of cancer. The awardees are Tony Hunter, American Cancer Society professor of molecular and cell biology at the Salk Institute for Biological Studies in San Diego, and Anthony Pawson, senior investigator and director of research at the S...New protein structure may aid in design of therapeutics for autoimmune disease
...g PKC in these cases would disable the T cells and halt the autoimmune reaction. Currently, several PKC inhibitors are being used in clinical trials for various types of cancer and diabetes-related retinopathy. "This structure provides a starting point for the rational drug design of high potency i...Random gene activation helps ulcer bug escape immune system
...ated from DNA to protein in a way that's likely to halt protein synthesis by introducing a premature stop signal." The net result, according to Berg, is that the bacteria's ability to stick to the Lewis B receptor is metastable--in every generation, a small number of the new bacteria will switch from a ti...Discovery of real-time natural gas formation offers prospect for renewable energy resource
...by altering their access to water or nutrients, or halt gas production entirely by exposing the organisms to oxygen or heat sterilization. This finding holds the potential of turning what is today thought to be a finite energy resource into a renewable source of natural gas that could potentially go on fo...UNC Lineberger researchers identify molecular markers of aging
...e known potent tumor suppressors, or proteins that halt tumor cell growth. The study suggests that the important anti-cancer function of these proteins to limit cellular growth might in turn cause aging. "Proliferation of cells is important in the repair and regrowth of tissues. In fact, we ...One-way processes speed degradation of coral reefs
...verse---for the failure of most current efforts to halt continuing losses. Birkeland identifies seven ecological ratchets that seem to contribute to the loss of coral reefs, including a decrease of corals' reproductive success that may occur at lower population densities, the disproportionate survival of ...Farmers don't need a new superstar toxin to fight bugs
...n of toxins - a superstar of toxins to effectively halt insect resistance to the current generation of insecticides," said Barry Pittendrigh, a Purdue associate professor of entomology and lead author of the study. "We found that moderately effective genetically engineered protectants used in plants in th......at a most critical time, when typically damage can halt replication altogether, may save the cell from near certain death. Harnessing its unique capabilities could have implications for treating some cancers. In the paper posted on the Web site of The EMBO Journal, an official journal of the European Mol...