Tag: "haplotype" at biology news
International HapMap consortium expands mapping effort
...reached completion of its first draft of the human haplotype
map, or HapMap, which will consist of 1 million ma...private collaboration will be an outstanding human haplotype
map that will provide a major new tool in the effort to combat human disease through an understandin...
Map of human genetic variation across populations may promise improved disease treatments
...tion over generations. At the same time, she said, haplotype
blocks of genetic sequences containing genetic var...e whole genome. Genomic data also were assigned to haplotype
maps, which were connected with bin patterns. Before they could identify bin or haplotype
California researchers help map human genetic variation across populations
... of the variation in the population. The resulting haplotype
'maps' across the three populations appeared quali... populations. According to the study, "LD maps and haplotype
maps represent somewhat different aspects of the local structure of genetic variation." "The partit...
Individual differences in taste perception directly related to genetic variation in taste receptors
...e of PROP and PTC. Subjects homozygous for the AVI haplotype
were 100 to 1000 times less sensitive to bitter ta...xperiment. These data implicate the responsive PAV haplotype
as a major determinant of sensitivity to the bitter taste of PROP and PTC in humans. "These data a...
Mitochondrial DNA variants linked to renal, prostate cancer
...or renal cancer. "The inheritance of mitochondrial haplotype
is important in cancer disposition," said John Pet...ry University and The Atlanta VA Medical Center. A haplotype
is a combination of variations in a gene. Like an asterisk fixed alongside the human genome, mitocho...
Inherited variations in mitochondrial DNA linked to renal and prostate cancer
... patients exhibited the haplogroup U signature. A haplotype
is a combination of variations in a gene. In addition to the variations in haplogroup U, Dr. Petros also found that 12 percent of prostate cancer patients had several missense mutations in a mitochondrial gene called cytochrome C oxidase subunit I...
DNA solves mystery of Gibraltar's macaques
... Moroccan colonies of macaques. Each mitochondrial haplotype
is identified by means of a specific DNA sequence....otypes are clearly distinct, evidence of any given haplotype
in the mitochondrial DNA of Gibraltar macaques would indicate that they descended from the geographi...
Variation in immune response gene causes age-related macular degeneration when triggered
... genetic variants in the Factor H gene known as a haplotype
that make them more susceptible to AMD. Different haplotypes in the Factor H gene in about one third of the population provide varied degrees of protection from acquiring AMD. The Iowa team also examined a large collection of donated eye samples an...
NHGRI expands effort to revolutionize sequencing technologies
...how to combine the sequence and maps into distinct haplotype
sequences. Gregory L. Timp , Ph.D., University of Illinois at Urbana-Champaign. $2.1 million (3 years) "Sequencing a DNA Molecule Using a Synthetic Nanopore" This group will explore the feasibility of sequencing a DNA molecule using a type of sil...
Human brain is still evolving
... polymorphisms are called haplotypes, whereby each haplotype
is, in essence, a distinct genetic variant of the ...e informative statistical data on the frequency of haplotype
D among population groups, the researchers applied their methods to a larger population sample of mo...
International consortium completes map of human genetic variation
...nsortium set an ambitious goal of creating a human haplotype
map, or HapMap, within three years. The Nature paper marks the attainment of that goal with its detailed description of the Phase I HapMap, consisting of more than 1 million markers of genetic variation, called single nucleotide polymorphisms (SNPs)....
Haplotype map offers new insights into human disease, evolution
...cross the genome. Based on these initial data, the haplotype
structure of the human genome was recognized as ea... 1576-1583. The International HapMap Consortium. A haplotype
map of the human genome. Nature. 2005;437(7063): 1299-1320....
California computer scientists double volume of data in NIH biotech repository
...the journal Nature. The group's HapMap is a map of haplotype
blocks and the tag SNPs that identify the haplotyp... School of Engineering. "We have demonstrated that haplotype
phasing can be done routinely every time there is a new release of data deposited in the NCBI databa...
Studies throw light on biomarkers which predict the subsets of patients where gefitinib has the greatest benefit
...ith PS 2 was higher in patients without the EGFR*1 haplotype
on one or more alleles (actual nucleotide sequence... one, during the first treatment cycle, the EGFR*1 haplotype
was associated with worse survival. Additionally, an association was seen between the EGFR haplotyp...
Researchers map of genetic variations implicated in disease
...ompared with the two previously described. The COX haplotype
has been associated with susceptibility to a wide ...lupus erythematosus and myasthenia gravis. The PGF haplotype
provides protection against type 1 diabetes and predisposes to other diseases such as multiple scler...
New analysis shows three human migrations out of Africa
... a unit. In 2002, Templeton analyzed ten different haplotype
trees and performed phylogeographic analyses that reconstructed the history of the species through space and time. Three years later, he had 25 regions to analyze and the data provided molecular evidence of a third migration, this one the oldest, ...
U-M scientists identify major psoriasis susceptibility gene
... psoriasis, U-M scientists used a technique called haplotype
mapping. Haplotypes are clusters of alleles that t... passed intact from generation to generation. If a haplotype
contains genetic changes that make people more susceptible to a disease, scientists can find it by c...
1 in 8 of Thomson Scientific's 2005 Top 40 'hottest papers' from three Oxford Journals titles
...y, Haploview: analysis and visualization of LD and haplotype
maps [ http://bioinformatics.oxfordjournals.org/cgi/content/abstract/21/2/263?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Haploview&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT ], which was recorded by Thomson Scientific as receiving a total of 9...
New method to analyse the Major Histocompatibility Complex (MHC) of the human genome
...ternational collaboration of scientists produced a haplotype
map of the human genome named the HapMap. The proj...ng distances of chromosome 6. This method provides haplotype
information without a family study, and may be useful for mapping genes of the MHC that cause common...
Biologists find regions of rice domestication
... look where the genetic signature of clusters on a haplotype
tree (family tree)," explained Londo. "We chose samples across the entire range of rice and looked for DNA sequences that were shared by both wild and domesticated types. These two major groups clustered out by geography." DNA is comprised of vast,...