Simulations unravel outer membrane transport mechanism
...s of atoms that guide large conformational changes happen on a very short time scale: femtoseconds, Tajkhorshid said. Each step relies on the completion of a previous step, so the simulations take an extensive amount of time and considerable computational effort. The researchers addressed two key question...Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism
...is well known that acute cardiovascular events may happen without the presence of the mentioned common risk factors. Recently inflammation and infectious agents have been shown to play an important role in the onset of acute cardiovascular events. The online, open-access PLoS ONE publishes a new study o...ACS News Service Weekly PressPac -- May 23, 2007
...study the two types of human diabetes. The changes happen before the appearance of toxic fatty materials regarded as a hallmark of diabetic cardiomyopathy and might be used as very sensitive biomarkers for the condition, the report indicates. ARTICLE #1 FOR IMMEDIATE RELEASE "Alterations in Myocardial Car...Understanding why C. difficile causes disease -- it's hungry
...ly large numbers in the intestinal tract. This can happen when the benign bacteria that normally inhabit the intestinal tract are reduced such as when people take antibiotics or other antimicrobial drugs. Then, C. difficile can cause symptoms ranging from diarrhea to life-threatening inflammations of the co...Nanotechnology requires immediate changes in EPA
...ons of dollars to the U.S. economy, but that won't happen if it is shrouded in uncertainty about its [environmental, health and safety] consequences.' " The report provides a thorough analysis of how nanotechnology can serve as a catalyst for change in EPA and existing regulatory frameworks. It identifies...Nanocomposite labeled cancer cells can be targeted and destroyed using lasers
...t has a mix of properties that would not otherwise happen in nature. By combining an organic matrix with metallic clusters that can absorb light, it is possible to incorporate such particles into cells and then destroy those targeted cells with a laser. In a presentation at the NSTI Nanotech 2007 Conference...Latent memory of cells comes to life
...osition of a specific DNA region. Changes can also happen during the lifetime of a cell due to chemical reactions allowing interconversions between the different nucleosome types. The effect of these changes can be that a latent capacity that was dormant comes to life, or, conversely, that a previously acti...University of Texas researcher earns APS Bowditch award
...e used to control hypertension. Its not going to happen tomorrow, but this research will allow people doing translational research to better the treatment methods for hypertension, Dr. Stockand said. The American Physiological Society has awarded Stockand the 2007 Henry Pickering Bowditch Memorial Award f...When smell cells fail they call in stem cell reserves
...nstant assault from harsh chemicals that one might happen to catch a whiff of by accident, risking damage or death. To figure out how the olfactory system repairs severely damaged nerve cells, Reed's team exposed mouse olfactory nerves to a cloud of toxic methyl-bromide gas. Methyl bromide kills not only...Short chromosomes put cancer cells in forced rest
...then continued breeding the mice to see what would happen in later generations. By the fifth generation, the researchers discovered that the mice had short telomeres and stopped developing lymphomas. When the researchers blocked the suicide machinery in these fifth-generation mice, they were very surpris...Scientists unravel clue in cortisol production
...tion of cortisol, the actual molecular events that happen in the nucleus are dynamic," said Sewer. "It's an extremely complex series of events that starts within minutes of the adrenal gland receiving the signal. Without all these transient binding events, the adrenal gland fails to produce optimal levels o...Study links faulty DNA repair to Huntington's disease onset
...ns disease. "The effect is much like what might happen if a technician came to repair a minor defect in your computer but was called away by a more urgent problem midway through the process. Now your computer is lying in pieces and youre unable to use it," said McMurray. The study suggests that OGG1 mi...Jefferson researchers' discovery may change thinking on how viruses invade the brain
...dical College. "We found that while transport must happen its essential to viral infection and spread and disease progression its not through this mechanism. Theres more to the story." "We think we have to have a closer look at how viral transport in general works," Dr. Schnell says. "Viral transport ha...Structural basis for photoswitching in fluorescent proteins brought into focus
...er. "Nathan looked at this and wondered what would happen if an oxygen atom was inserted at a precise place," Remington said. "That would make for a favorable interaction that stabilized the dark state. Based on the structure, Henderson made a single mutation that delays the switch-on time from five minutes...Bronfman gift to Mount Sinai catalyzes genomics-based medicine
...ssage to the world that medical innovation can not happen without the dedication and support of community visionaries," said Dennis S. Charney, M.D., Dean of Mount Sinai School of Medicine and Executive Vice President for Academic Affairs of The Mount Sinai Medical Center. "This gift will bridge the gap bet......ecome the masters in the summer, though it all may happen gradually. We don't know how the switch from slave to master actually happens, but at some point, one type of cell appears to take full control." The study also sheds light on a poorly understood relationship between depression and circadian rhythm...Gene mutations linked to hereditary lung disease
...lomeres, such as older age and smoking, which also happen to be the main risk factors for IPF." To determine the link between short telomeres and non-inherited IPF, investigators will need to study a larger group of these patients. If studies reveal a solid link between the two, Armanios says that it ma...International risk research strategy and funding needed for nanotech safety
... billions of dollars to our economy, but that wont happen if it is shrouded in uncertainty about its consequences. The American government needs to take action urgently in three critical areas of nanotechnology: first, documenting what relevant risk research exists; second, ensuring that agencies respons...MIT biologists solve vitamin puzzle
...e DMB. "It looked like a number of things had to happen in order to make the DMB," said Walker. "We originally thought that BluB might be just one of several enzymes involved in DMB synthesis." Therefore, it came as a surprise when Taga isolated the BluB protein and showed that it could make DMB all by ...... of whom will die. Your only options are to let it happen or to kill the person. Do you pull the trigger? Most people waver or say they could not, even if they agree that in theory they should. But according to a new study in the journal Nature, subjects with damage to a part of the frontal lobe make a ...