High blood pressure, low energy -- a recipe for heart failure
...pha developed symptoms of heart failure when their hearts were forced to pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes ...Abnormal fat metabolism underlies heart problems in diabetic patients
...t the very earliest stages of diabetes. "Diabetic hearts run mostly on fats for fuel because glucose isn't ...d because cardiolipin was first discovered in beef hearts and is one of the most abundant lipids in heart tissue. This lipid has unusual physical properties t...Antioxidant overload may underlie a heritable human disease
...an early death. They further show that the animals hearts are under reductive stress. The find initially t...tioxidant known as glutathione. The mutant mouse hearts exhibited a heightened stress response, including higher activity of heat shock proteins that have b...Cardio exercise benefits in male vs. female hearts
...ance, time, and average speed were recorded. Their hearts were monitored using an echocardiograph to better evaluate any cardiac changes during the course of the study. They also isolated and analyzed the RNA of each mouse to look at any changes at the molecular level. Results The researchers found that ...Sugar and spice and everything nice: Health differences in newborn girls and boys
...s in both sexes prior to isolating the hearts. The hearts were then subjected to 60 minutes of normothermic ...e. The researchers found that the newborn female hearts had accumulated a significant 47 percent greater H+ level within 60 minutes of ischemia. This was as...Using stem cells to help heart attack victims
...d facilitate their use in regenerating the damaged hearts of heart attack victims. Dr Chris Denning, of the Universitys Wolfson Centre for Stem Cells, Tissue Engineering & Modelling, said: Human embryonic stem cells promise unrivalled opportunities. However, they are difficult, time-consuming and expensi...System to analyze beating heart stem cells could lead to heart attack treatments
...d facilitate their use in regenerating the damaged hearts of heart attack victims. Human embryonic stem cells promise unrivalled opportunities. However, they are difficult, time-consuming and expensive to grow in the lab, Dr Denning explains. Our understanding of how to convert them into cardiomyocytes i...JCI table of contents: July 19, 2007
...lls during gestation or following birth. Embryonic hearts containing the mutated SHP2 had altered cardiomyocyte cell cycling and structural defects, while expression of the mutant protein in postnatal cardiomyocytes had no effect. Fetal expression of this mutated protein was found to activate the ERK1/2 pat...Cardiac patches stimulate regeneration, improve function after heart attack
When human hearts are injured, as during a heart attack, healthy tissue normally cant regrow. Researchers now demonstrate in rats that a sponge-like patch, soaked in a compound called periostin and placed over the injury, can not only get heart cells to begin dividin...Specific type of cell death may accelerate decompensated heart failure
...n times of stress, may paradoxically cause harm to hearts already weakened by disease, researchers from UT Southwestern Medical Center have found. In certain forms of heart disease, autophagy is taking place, but how much of it is occurring and whether it participates in disease pathogenesis is unknown, ...JCI Table of Contents -- July 2, 2007
...calcium in cardiac muscle cells is critical to the hearts mechanical contraction and relaxation. Mutations in calcium-handling proteins in the heart have been linked to exercise-induced sudden cardiac death. The best characterized of these have been mutations in the cardiac calcium release channel known as ...JCI table of contents: June 21, 2007
... the severity of harmful structural changes in the hearts of these animals. Taken together, the data implicate autophagy in the development of pressure/load-induced heart failure and as such it may be a target for novel therapeutic intervention. Title: Cardiac autophagy is a maladaptive response to hemody...Link between obesity and enlarged heart discovered by University of Arizona researchers
...ing of the heart muscle in the left ventricle, the hearts pumping chamber. Known to physicians as left ventricular hypertrophy (LVH), the condition potentially can lead to heart failure and rhythm problems. We observed that the thickening in the muscle wall becomes especially noticeable in obese patients...JCI table of contents: June 14, 2007
...ontractility and malformed vessels observed in the hearts of these mice and provides insight into the signaling events that underlie DCM. TITLE: Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling AUTHOR CONTACT: Naoki Mochizuki National Card...Breakthrough for treatment of fatal heart condition
... sudden cardiac death in athletes, as hypertrophic hearts are unable to cope with intense physical activity....own as ANP and BNP, are naturally higher in foetal hearts and the hearts of babies and children, but should drop as an individual matures. However, in adults ...ACS News Service Weekly PressPac -- May 23, 2007
...echnology termed "shotgun lipidomics" to show that hearts of diabetic mice lose large amounts of cardiolipin (CL), fatty materials essential for the heart's production of the energy needed for normal contraction. The changes, which involved a loss of CL followed by changes in the remaining CL, occurred as e...Jefferson scientists use gene therapy to reverse heart failure in animals
... beta-blockers only partially rescued the animals' hearts in failure and that S100A1 gene therapy alone was ... protein S100A1 above normal helped protect animal hearts from further damage after simulated heart attacks. In some cases, the animals' heart function hardly...UVa researcher studying disease that cripples newborns
...eturned to normal. Only mice with severely damaged hearts did not recover. We showed in our mouse model that when you make this poisonous RNA, the mice get various aspects of myotonic dystrophy, Dr. Mahadevan said. Then, when you take away the toxic RNA, the mice get back to normal. The UVa study appe...Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
...ronary flow in female (10.40.8 vs. 7.10.7, P 0.05) hearts at baseline; nicotine treatment significantly decreased coronary flow during reperfusion up to 60-minutes in female, but not in male, hearts. prenatal nicotine exposure significantly increased ischemia and reperfusion-induced infarct size in......the sexes. The researchers hypothesized that male hearts would have higher citrate levels and females would benefit more from the stimulation of PDH than males. The study also sought to determine if sodium cyanide (NaCN) -- an inhibitor of oxidative metabolism V decreases activity of the glycolytic path...