Tag: "hemophilia" at biology news
Embryonic stem cells treated with growth factor reverse hemophilia in mice
...e treatment of liver-based genetic defects such as hemophilia
A and B in humans. Mouse embryonic stem cells tre...and then injected into the liver reverse a form of hemophilia
in mice analogous to hemophilia
B in humans, the new study shows. A report of the study appears in t...
Bayer donates equipment to Children's Hospital, Oakland for infectious disease research
...nutrition, cancers, sickle cell disease, AIDS/HIV, hemophilia
and cystic fibrosis....
Gene therapy completely corrects hemophilia in laboratory animals
Newborn mice and dogs with hemophilia
A were restored to normal health through gene ther... achieved in prior attempts using gene therapy for hemophilia
A in dogs," says senior author Katherine Parker Ponder, M.D., associate professor of medicine and of...
LSU scientists develop new theory about human genome evolution by tracking 'stealth' DNA elements
...enetic disorders related to these elements include hemophilia
and some cancers. These disorders are caused by insertional mutation or by recombination between these elements, which is when elements that are near each other undergo a "recombination" and part of the genome is deleted in the process. Batzer's t...
New results validating Pall prion reduction filter disclosed at ISBT Congress
...Society also issued a warning to 6,000 people with hemophilia
that they could have caught the disease through infected blood. In the U.S., a second cow just tested positive for BSE. "Considering the lengthy, asymptomatic incubation period of vCJD in people, no one can accurately determine the magnitude of the n...
Redesigned protein accelerates blood clotting
...ve bleeding in 30,000 Americans. In most cases, hemophilia
is caused by a lack of factor VIII, one of several proteins that enable blood to solidify, or clot, to plug wounds after injury. Current preventive treatment consists of genetically engineered factor VIII administered by injection, but one quarter o...
Gene therapy advance treats hemophilia in mouse models
...nt potential for developing improved treatment for hemophilia
but are not yet applicable to people, cautioned Pa...hieve levels of gene expression that converted the hemophilia
A in the mouse from a severe to a mild form. The correction lasted 30 weeks -- the duration of the s...
New technique adds precision and permanence to gene therapy
...diseases caused by missing liver enzymes including hemophilia
and urea cycle enzyme deficiencies, as well as cholesterol clearing from the blood and others....
Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
...chnique that has shown promise in skin disease and hemophilia
might one day be useful for treating muscular dyst...ure for the disease and for other diseases such as hemophilia
and the skin disease, epidermolysis bullosa. Early trials using her approach have looked promising i...
Polymer aids in blood clotting, pointing way to new treatment
... sustained on battlefields or in accidents, or for hemophilia
and other diseases with coagulation deficits. "The big picture is that we've found a new function for an ancient molecule," he said. "Polyphosphate has been around for billions of years. Roberto's discovery that the granules in platelets are like the...
Missing steps of jumping-gene replication discovered
... a rare cause of several genetic diseases, such as hemophilia
and Duchenne muscular dystrophy. Retrotransposons are one class of jumping genes, with the L1 family being the most abundant in the human genome. Retrotransposons move by having their DNA sequence transcribed or copied to RNA, and then instead of th...
Chromosome rearrangements not as random as believed
...ke single-gene diseases such as cystic fibrosis or hemophilia
that result from mutations in one gene, genomic diseases originate in the broader structure of the genome--the full complement of DNA sequences in sets of chromosomes. Recent research by Drs. Emanuel, Kurahashi and colleagues have detected other pali...
Ancient DNA helps UF researchers unearth potential hemophilia therapy
... degree to which these patients have problems from hemophilia
stems from how much of this protein, factor VIII, .... More than 18,000 Americans, nearly all men, have hemophilia
A, the most common form of the disease, according to the Centers for Disease Control and Prevention....
X chromosomes key to sex differences in health
...Such diseases include Duchenne muscular dystrophy, hemophilia
and Hunter syndrome, which causes dwarfing, abnormal bones and mental retardation in males but usually does not affect females who carry the same mutated gene. This duplication of genes is generally advantageous to women, but is not as straightforwar...
Gene sequencing center to receive $156 million
...ntify genes involved in X-linked diseases, such as hemophilia
and Fragile X. As part of the grant, Washington University's Genome Sequencing Center will continue to refine and improve scientists' understanding of the human genome sequence. "Just like any good encyclopedia, you always want to improve and update...
A transplant in time
... a critical blood-clotting protein. Treatments for hemophilia
and other such genetic diseases, when they exist, may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the body could be induced to begin producing these proteins, say by transplanting healthy tissue with the a...
Biogen Idec acquires Brandeis spin-out
...here they have preclinical candidates for treating hemophilia
and infertility. Biogen Idec's acquisition is an e...long-acting factor IX product for the treatment of hemophilia
B. It has the potential to reduce the frequency of intravenous injections required for disease manag...
VIB scientist receives major research grant
... the Hemophilia Research Award for his research on hemophilia
− a hereditary disorder affecting coagulatio... coagulation factor VIII. This condition is called hemophilia
A. The rest of the patients most often have a shortage of coagulation factor IX (hemophilia B). The ...