Tag: "heterozygotes" at biology news
No getting around RET
... the GFR1 gene died in the perinatal period, while heterozygotes
(which carried only a single copy of the transgene) were healthy and fertile. On comparing specific embryonic regions in hetero- and homozygous mice, they found associations between RET-expressing and RET-independent GFR1 cells in kidney, enteric and...
PTEN, TSC2, and tumorigenesis
... Cancer Center) also found that compound Pten/Tsc2 heterozygotes
displayed accelerated tumorigenesis, with Tsc loss enhancing Pten-heterozygous tumor phenotypes. However, the authors also identified a non-reciprocal relationship between PTEN and TSC2 in tumorigenesis: TSC2 can suppress formation of specific tumors...
Gene mutation may influence age at onset of Parkinson's disease
... researchers had not previously determined whether heterozygotes
were at increased risk for Parkinson's disease. P...blings shared the same version of the parkin gene, heterozygotes
developed Parkinson's disease an average of 11.7 years earlier than those with no mutations, and tho...
Scientists develop a new diagnostic approach for carriers of recessive genetic disorders
... normal, although some reports have suggested that heterozygotes
may have an increased risk of cancer. Using microarray technology, which simultaneously ascertains the expression patterns of thousands of genes, Cheung and Ewens discovered that heterozygous carriers of NBS exhibited distinct gene expression patte...
Sweet yet sophisticated: Honey bee genome lends insight into sociality, sensation and sex
...zed eggs with only one copy of csd ) become male, heterozygotes
(with two different copies of csd ) become female, and homozygotes (with two exact copies of csd ) develop into males that are eaten by workers after they hatch. Because the homozygotes do not survive to reproductive age, csd was theoretically ...