Tag: "histone" at biology news
BU chemist to map DNA's surface, uncovering details that will show how structure abets function
...omatin has a complex structure -- it twists around histone
proteins, turns upon itself, and, in general, is not an easily accessible item, especially for proteins that need to bind to it for transcription. It is known, however, that this structure is dynamic and that DNA spontaneously unwraps to allow prote...
Stowers researcher publishes DNA double-strand break repair discovery in Science
...andidate tumor suppressors including a specialized histone
variant called H2A.X/v. H2A.X/v itself becomes phosphorylated by a DNA damage- recognizing factor in the proximity of DNA double-strand breaks. This finding raised the possibility that the complex, which was called the dTip60 complex, might specifica...
Discovery of first demethylase molecule, a long-sought gene regulator
...ny people didn't believe existed." The enzyme, a histone
demethylase, removes methyl groups appended to histone
proteins that bind DNA and help regulate gene activity. "Previously, people thought that histone
Solving the mechanism of Rett Syndrome
... of gene suppression, MeCP2 acts in concert with a histone
deacetylase protein, HDAC1, and other proteins. Histones are proteins in chromatin equipped with little "tails" that, when attached to an acetyl group (CH3OH), relax to allow the chromatin structure to become open or less compacted. When acetyl group...
Scientists identify molecular events that drive cell senescence
...ladelphia. Dr. Adams and colleagues found that the histone
macroH2A is specifically enriched in SAHF. Histones are proteins that are associated with chromatin structure. The researchers also demonstrated that HIRA and ASF1a, two known regulators of chromatin structure, play a key role in formation of SAHF. W...
In Nature paper, scientists at U.Va. health system crack part of 'histone' code
...s is a good example of how proteins respond to the histone
code," explained study senior author Patrick Grant...ently emerged about how genes can be turned off by histone
methylation and how abnormal chemical modification of histones may underlie the formation of certain...
Man and mouse share genome structures
...matin is composed of DNA spooled around bundles of histone
proteins, and resembles a chain of beads which is ...st exciting to Bernstein is the unusual density of histone
tags spread over the regions of genome containing the HOX genes, which are key regulators of develop...
Enzyme shown to help protect genomic stability
...ils of DNA around the histones are loosened or the histone
molecules are altered, the genes become available for expression. It is the complex activity governing this process to which Ubp10 contributes. Enzymatic modifications to histones control DNA activation or silencing through the addition or removal o...
ASBMB Schering-Plough Award lecture to focus on histone modifications in transcription
...Brian Strahl will discuss the important roles that histone
modifications play in DNA transcription when he re...Rad6, which is responsible for adding ubiquitin to histone
2B. Normally in cells, DNA is wrapped around an octamer of histones. When the cell is ready to expre...
Study finds enzyme activity promotes rare form of leukemia, offers potential target for new drugs
...tigates a group of enzymes that modifies five core histone
proteins forming the molecular scaffold that helps...on, in which a methyl component is attached to the histone
protein. "The prevailing model is that methylation on histones serves as a docking site," Zhang sai...
UCR chemist part of team identifying new areas of gene regulation
...the current team, discovered in 1991 that sites of histone
acetylation, a modification of the protein, play a...ometry to show that acetylation at the core of the histone
is associated with gene activation by attracting the protein string known as the SWI/SNI chromatin r...
Protein helps regulate the genes of embryonic stem cells
...form of chemical modifications on any of four core histone
proteins that group together to provide a molecula...on, in which a methyl component is attached to the histone
protein. The prevailing model is that methylation on histones serves as a docking site for proteins...
Novel combination overcomes drug-resistant myeloma cells
...ad Institute designed a drug, tubacin, that blocks histone
deacetylase 6, an enzyme that is critical to the aggresome's ability to function. These highly promising results, wrote the researchers, "provide the framework for clinical trials designed to enhance sensitivity and overcome resistance to bortezomib ...
Heterochromatin assembly in S. pombe
...quent proteasome-dependent degradation may control histone
methylation and heterochromatin formation," explains Dr. Peterson....
Molecular partners required for appropriate neuronal gene repression
...hile the enzyme was able to demethylate its target histone
when the pair was in isolation, it was unable to do so when the histone
was placed in the more complex and realistic setting of a nucleosome. They then coupled the enzyme w...
Study identifies protein's role in cell division
...ow Upf1 prevents the cell from making any unwanted histone
proteins during the intervals between DNA synthese...e a cell divides, it has to replicate both DNA and histone
proteins and then package the two together into chromosomes," Marzluff said. "That way, each of the ...
Study finds protein is required for human chromosome production
...called CPSF73 acts like scissors to cut strands of histone
messenger RNA (mRNA) in the cell nucleus. This cutting action produces the mRNA needed to create histone
proteins that combine with DNA to form chromosomes. Like all other proteins, histones are made when ...
The meiotic histone code
...ic analysis of the recently identified nucleosomal histone
kinase, NHK-1. The authors generated NHK-1-mutant ...lting sterile female oocytes, determined that this histone
kinase is necessary for disassembly of the synaptonemal complex, condensin loading, and the further ...
Not so different
...Steitz (Yale University) lend new insight into the histone
pre-mRNA processing machinery, and reveal the surp... paper identifies the long sought-after factor for histone
pre-mRNA processing what has simply been known as the "heat labile factor" (HLF) nearly 20 years a...
Delving deeper into the machinery of cocaine addiction
...rocess called "chromatin remodeling"--in which the histone
proteins enfolding genes are chemically altered to...ation assays" to measure the effects of cocaine on histone
proteins. This technique, they emphasized, makes it possible "to study such transcriptional mechanis...
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