Tag: "homeostasis" at biology news

Is Interleukin-6 the 'holy grail' of exercise mediation?

...eem to produce IL-6 in order to maintain metabolic homeostasis during periods of altered metabolic demand such as muscular exercise or insulin stimulation. Such a powerful effector has also attracted some negative reaction, but Pedersen notes that IL-6 overall seems to have a "positive metabolic role in health...

Scientists identify new cause of obesity

...ht is unveiling new ways to think about how energy homeostasis is maintained," said Supriya Srinivasan, a postdoctoral fellow at the Gladstone Institute and co-lead author of the study. The discovery suggests a promising new strategy to combat obesity, the scientists report. Rather than developing drugs that sig...

Diabetes drug works by enhancing fat cell energy production

Energy homeostasis is controlled by a complex series of cellular and hormonal interactions. White fat tissue has been shown by mouse-knockout studies and the identification of fat-specific secreted factors to be central to this process. Drugs for type 2 diabetes that e...

JCI table of contents November 1, 2004

...ks by Enhancing Fat Cell Energy Production Energy homeostasis is controlled by a complex series of cellular and hormonal interactions. White fat tissue has been shown by mouse-knockout studies and the identification of fat-specific secreted factors to be central to this process. Drugs for type 2 diabetes that e...

Fat hormone acts on brain circuit to curb obesity, diabetes

...arcuate nucleus is required for normal body weight homeostasis and is sufficient to control leptin's anti-diabeti... leptin signaling also remarkably improved glucose homeostasis in the mice. Eight weeks after the treatment, blood glucose levels in the mice were indistinguishabl...

William C. Aird, MD, receives Established Investigator Award from American Heart Association

...y, widely believed to play a critical role in both homeostasis and vascular disease states. Aird's laboratory will use the award in their continued investigations of the mechanisms that underlie differential gene expression within the endothelium and to gain a better understanding of how the endothelial cells li...

JCI table of contents March 1, 2005

... RSK2 is bad to the bone Proper bone homeostasis relies on a delicate balance between bone deposition by osteoblasts and resorption by osteoclasts. The transcription factor c-Fos modulates both of these cell types, and, when overexpressed, causes a bone cancer called osteosarcoma. c-Fos activity ...

JCI table of contents March 1, 2005

...tant protective role for type I IFNs in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for intestinal inflammatory conditions." TITLE: Toll-like receptor 9-induced type I IFN protects mice from experimental colitis AUTHOR CONTACT: Eyal Raz University ...

A new route for treatment of IBD

...tant protective role for type I IFNs in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for intestinal inflammatory conditions."...

Iron exporter revealed that may explain common human disorder

...n patients with the disease, perturbations in iron homeostasis result from a failure to control iron export through ferroportin, leading to increased iron release from macrophages and enhanced intestinal absorption. Indeed, patients with the disease exhibit a deficiency of hepcidin, a hormone that binds ferropor...

Balancing act at chromosome ends

...RN1 plays an important role in modulating telomere homeostasis through dynamic control of hTERT protein stability and could represent a novel target for anti-cancer drug development."...

Two-part blood pressure control suggests new approach to hypertension therapy

... also make a unique contribution to blood pressure homeostasis that is virtually equivalent to and independent of their actions within the kidneys." The results illustrate the complexity of blood pressure regulation and suggest that maximal efficacy of hypertension drugs, including ACE inhibitors and angiotensin...

JCI table of contents April 1, 2005

...receptor substrate 2 (IRS2) plays a role in energy homeostasis and mice that lack this protein develop diabetes. However, mice that lack IRS2 in only certain cells of the pancreas and brain do not develop diabetes, raising a number of questions. In a study appearing in the April 1 issue of The Journal of Clini...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

...mportant areas of biological research: stem cells, homeostasis (tissue loss and replacement), regeneration, and d...hat separate genetic pathways for regeneration and homeostasis must exist," Snchez Alvarado said. "It's a huge step forward for us and opens the possibility of sys...

Newly discovered genetic disease sheds light on body's water balance

...he mechanisms that the body uses to maintain fluid homeostasis -- the correct balance of fluids needed for health... of NSIAD may offer additional insights into fluid homeostasis and clinical disease, as well as expand our understanding of GPCR signaling." The group is now condu...

Oxytocin/vasopressin research sees new clinical applications, key role in social behavior

..., Celia Sladek, said. "Their effects go from water homeostasis and cardiovascular function to parenting and monogamous behavior, even eating and perhaps autism," she added. "The neurohypophyseal system itself is a model for studying neuronal mechanisms, gene regulation/mutation and glial plasticity," noted Slade...

JCI Table of contents August 1, 2005

...light the central role of beta Klotho in bile acid homeostasis and raise the possibility that this protein could be a pharmacological treatment for gallstones." TITLE: Impaired negative feedback suppression of bile acid synthesis in mice lacking beta Klotho AUTHOR CONTACT: Yo-ichi Nabeshima Kyoto University ...

Leptin-signaling protein maintains normal body weight and energy balance in mice

...hopes to learn more about the set point for energy homeostasis and body weight in the brain. He also will continue his previous research on how SH2-B contributes to the development of insulin resistance and type 2 diabetes. And he wants to join forces with a clinical collaborator to screen patients with obesity ...

JCI table of contents September 1, 2005

...ggest that SOCS-7 is a potent regulator of glucose homeostasis and insulin signaling. TITLE: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of langerhans AUTHOR CONTACT: Paul B. Rothman University of Iowa, Iowa City, IA USA Phone: 319 384 5424; Fax: 319 356 8608; E-mail: paul-...

Insulin sensitivity gets a kick out of SOCS-7

...ggest that SOCS-7 is a potent regulator of glucose homeostasis and insulin signaling....

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