Joslin researchers discover new gene for type 2 diabetes using DNA chips
...ion. As a component of the response to toxins and hypoxic stress, ARNT is also at a potential site to integrate genetic and environmental insults. "While previous work suggested defects in other pathways in a small percentage of people with type 2 diabetes, what was unexpected was that the islets (beta ce...JCI table of contents August 1, 2005
...echanism for NO formation is suited for regulating hypoxic vasodilation under a variety of physiological and ...therapies that target NO delivery to tissues under hypoxic stress using nitrite solutions. Title: Enzymatic Function of Hemoglobin as a Nitrite Reductase th...Pomegranate juice for moms may help babies resist brain injury
...ead to seizures, a degenerative condition known as hypoxic ischemic encephalopathy, and mobility impairments including cerebral palsy. When scientists temporarily lowered brain oxygen levels and brain blood flow in newborn mice whose mothers drank water mixed with pomegranate concentrate, their brain tissue...Cell's power plants also sense low oxygen
...arly development, the embryo exists in a naturally hypoxic environment until it is connected to the maternal ...a new technique to precisely measure ROS levels in hypoxic cells. "Our studies of cells with mitochondrial deficiencies showed that they do not accumulate HIF ...Studies reveal how cells sense oxygen
... under low oxygen conditions regulate a variety of hypoxic responses, including the activation of hypoxia-inducible factor 1 (HIF-1). HIF-1 is a master regulator of local cellular and systemic responses to oxygen starvation. In the new studies, the groups used a variety of genetic methods to specifically dis...'Dead zone' area in Gulf could be increasing, researchers say
...oticed continue, it could mean an unusually strong hypoxic zone this year, and that's not good news." DiMarco said the team studied an area between Southwest Pass, La., and the Calcasieu ship channel. They were on the Gyre, a research vessel owned by Texas A&M, and the project is funded by NOAA (National Oc...Children of mothers with preeclampsia more likely to have pulmonary hypertension
...e that can predispose the offspring to exaggerated hypoxic pulmonary hypertension in later life. The study also illustrates how field research at high altitudes can provide important clues in understanding a major clinical disease like pulmonary hypertension. Dr. Pierre-Yves Jayet, a research fellow in the ...UT Southwestern researchers see hope for treating blindness in preemies
...s too low, and their bodies set off the protective hypoxic response. In the retina, HIF-2a may be triggered inappropriately, Dr. Garcia suggested, and unnecessary blood vessels are created. "Finding a way to shut down HIF-2a in ROP babies could prevent blindness when they come back down to regular oxygen...