Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme
Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door.... ...And for good reason. ... ...He has labored for years over trying to understand and detail the behavior of insulin-like growth factor-1 (IGF-1) receptor, a protein which plays an important role in tumor growth. Several years ago he and his co-workers discovered that normal cells lacking the IGF-1 r...Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
WINSTON-SALEM, N.C. Deficiencies of growth hormone and similar compounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, according to research at Wake Forest University Baptist Medical Center and four other institutions.... The researchers used a rat model to explore the effects of growth hormone and anothe...