Gene silencing directs muscle-derived stem cells to become bone-forming cells
...not observe any bone formation when the cells were implanted in skeletal muscle. Yet, when they turned off ostegenic inhibition in these same cells using Smad6 siRNA prior to implanting them in mice, 60 percent of the mice developed radiologically detectable bone within three weeks. "By understanding the gene...Purdue researchers find 'switch' for skeletal-muscle atrophy
...lectrical current across the cell. The researchers implanted a gene into the skeletal muscle that resulted in a mutant form of this protein that combines with the normal protein and stops the current. The researchers found that the mutant protein would inhibit atrophy in mice whose ability to use their back le...First high-flex knee replacement implant shaped specifically to fit woman's anatomy
...ete Knee System. The Gender Solutions Knee will be implanted using existing, clinically successful surgical techniques, including Zimmer's minimally invasive approaches. Rosenberg and other surgeons who helped with development will be using the implant in patients next week. The implant is expected to be globa...Lack of a key enzyme dramatically increases resistance to sepsis
...ause of his work, we were able to use a surgically implanted stent in the colon that allowed a gradual occurrence of sepsis and easy identification." A majority of mice with caspace-12 died from sepsis within the first 48 hours after onset, while 60 percent of the caspase-12 deficient mice survived. The defici...NJIT students present leading research during Provost's Student Research Showcase
...astic, track the pressure on the brain. The shunt, implanted in the patient's brain, will send pressure readouts to a wireless device. If readout shows that pressure is high, doctors might have to operate. But if the pressure is low, doctors will not operate unnecessarily. "Right now, shunts that are used are ...Using stem cells to repair torn tendons
...earchers filled small sponges with these cells and implanted the sponges into torn Achilles tendons of rats, they found that the cells not only survived the implantation process, but were also able to invade the injury and repair the tendon for at least 7 weeks after implantation. The cells changed their appea...Electrical stimulation boosts stroke recovery
...ctrical impulses sent to two electrodes surgically implanted in the brain to block the signials that cause the disabling motor symptoms of the disease. "It's like DBS, except that we don't go deep into the brain," Lutsep emphasized. "It's considered generally safer, less invasive, but on the other hand, we sti...Troubling times for embryo gene tests
...s that would be bone-marrow matches for Jordan and implanted them at a hospital in Atlanta in early 2003. Julia and Jorjia were born 34 weeks later. Both have Fanconi anaemia. Fortunately, reports of such errors connected to clinical genetic testing are extremely rare. Mark Hughes, the founder and chief clinic......his high-tech observation that involves surgically implanted transmitters for approximately a year. The scientists have designed a field study that uses acoustic telemetry technology to track continuously the movements and habitat use of red and black grouper in the Dry Tortugas National Park, the 46-square-na...Engineering nerve jumper cables for spinal cord repair in animal model
...lled into a form resembling a jelly roll, and then implanted into a rat model of spinal cord injury. "That creates what we call a nervous-tissue construct," says Smith. "We have designed a geometrical arrangement that looks similar to the longitudinal arrangement that the spinal cord had before it was damaged...UCI researchers discover key factor for survival of human embryonic stem cells
...ll the undifferentiated stem cells before they are implanted into the body. According to Donovan, the studies also offer further proof that new stem cell lines need to develop beyond those already in existence. Federally approved hES lines currently used for research were not created in the presence of growth...New targeted treatment for brain tumors shows promise in pre-clinical models
...he effectiveness of L2G7 in treating human gliomas implanted in mouse models. Results indicate that treatment ...romising results were observed in mice with tumors implanted within the brain. In this setting, L2G7 not only induced tumor regression, but dramatically increas...Wisconsin scientists find a way to make human collagen in the lab
...ology -- such as microscopic sensors that could be implanted in humans to confront the effects of disease -- because it gives scientists a way to precisely manipulate the lengthy molecules and add elements to collagen that confer new abilities. "We can make collagen that duplicates nature exactly, but we can ...Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
...th which this is thought to occur in patients with implanted defibrillators." The researchers' analysis reveale...hythm abnormalities, Bursac said. In patients with implanted defibrillators, the devices often attempt to terminate ventricular tachycardia by delivering electri...Protein found to control tumor growth in certain breast cancers
...ese initial findings one step further, researchers implanted estrogen pellets in the SCID mice to accelerate tumorigenesis. In those mice receiving Nod1 cell lines tumor growth did not occur even in the presence of estrogen pellets, indicating that Nod1 acts as an effective cellular brake on estrogen-dependen...ASU's Nanotech in Society Center hosts launch event
...health, there are doomsday scenarios of nano-chips implanted in the brain that forever alter human identity or nano-sensors publicly revealing all private places and information. How can scientists, citizens, and policy makers be adequately engaged in a dialogue about nanotechnology's potential for good and il...NJIT engineer poised to take stem cell research a step forward
...em cells taken from one person can be successfully implanted into another. A list of conditions for which stem-cell treatment holds promise grows almost daily: It now includes Parkinson's, diabetes, Alzheimer's, cancer and traumatic brain injury. "Treena's research is exciting because she has had success in c...Rockefeller researchers discover a biological clock within a clock
... and roll into the nucleus," Young says. "Somehow, implanted within the system is a timer, formed by Period and Timeless, that counts off six hours. You have a clock within a clock." He notes that this precise timer shows how carefully orchestrated interactions between proteins really are. Young and Meyer, wh...A new window into structural plasticity in the adult visual cortex
...tex. To allow direct observation of the area, they implanted a glass window over the two areas of the visual cortex in four- to six-week-old mice. These mice express fluorescent protein in neocortical neurons, allowing Lee et al. to track the location and morphology of these neurons using two-photon microscop......(autologous myoblasts from the animal itself) were implanted by surgical and percutaneous means. The results of this study revealed that this implantation of stem cells improved the function of the left ventricle: there was observed a significant increase in vasculogenesis and a significant decrease of fibros...