Transplanted stem cells show promise for mending broken hearts
...One intriguing result of the new study is that the implanted cells did not result in tumor formation, one of the primary safety concerns for stem cell therapy. Like cancer cells, embryonic stem cells have a capacity to reproduce indefinitely and scientists must perfect cell transplant methods that are safe bef...Genetic testing still smart choice, despite uncertainties
...are discarded as abnormal and only 1.5 percent are implanted with undetected genetic defects because of mosaicism. To find out how big of a problem mosaicism is, the researchers developed a mathematical model using data from UF's IVF program and other programs to illustrate the different paths an embryo takes ...Engineered stem cells show promise for sneaking drugs into the brain
...ely deliver the drug to the brain, Svendsen's team implanted the GDNF secreting cells into the brains of rats a...tically modified to secrete the growth factor when implanted in the striatum, a large cluster of cells in the brain that controls movement, balance and walking. ...'Fish with chips' reporting from ocean top highlights at Census of Marine Life mid-point
...losed to conserve endangeredstocks. The salmon are implanted with almond-sized electronictags scanned by devices on the ocean floor when theypass over, like an electronic tag on a car passingthrough a highway tollbooth (see animation athttp://www.postcoml.org/videos/how_it_works.htm). Thedata reveal the movem...New UW study offers strategy for treatment of fatal nervous system disorder
...that lacks any myelin, the group observed that the implanted cells took up the enzyme from the host cells and sparked widespread and persistent myelination of the brain and spinal cord. "The donor cells are stable and survive and, biochemically, enzyme levels in the graft were restored to normal," says Kondo. ...Preclinical study of a new brain tumor therapy
...ers found that the treatment was effective in mice implanted with human brain tumor cells that overexpressed EGFR. The treatment could eliminate established cancers and there was no evidence of recurrence: the mice remained cancer free for over a year. It is more difficult to cure cancer in humans than cancer ...Polymer gel can block toxic leakage problem in gene therapy
...g 24 hours after being injected into breast tumors implanted in experimental mice. That investigation showed th...dy reported. In comparative tests on breast tumors implanted in live mice, the authors noted that two mice in the group injected with adenoviruses without poloxa...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
... injected nanoshells into the blood stream of mice implanted with colon cancer knowing, based on previous experiments, that the nanoshells would preferentially accumulate in the tumors. This occurs because blood vessels that develop in fast-growing solid tumors are ill-formed and permeable, and nanoshells trav...Stem cells' electric abilities might help their safe clinical use
... could selectively block some of these channels in implanted cells, derived from stem cells, they may be able to prevent potential tumor development. The paper appears Aug. 5 online in the journal Stem Cells. "A major concern for human ESC-based therapies is the potential for engineered grafts to go haywire a...Radical approach to cardiac resynchronization shows promise
...theter inserted through the pig's jugular vein, he implanted pacing leads by puncturing the upper chamber of th...the lead ideally. In these patients, leads must be implanted in highly invasive open chest surgery. "This new technique allows for optimal lead placement throu...Nanoparticle created as diagnostic, therapeutic agent; brain tumors targeted
...imaging and drug delivery methods to detect tumors implanted in a rat's brain. They found that the nanoparticles highlighted the tumors more effectively than existing imaging agents. The fMF material provides improved brain tissue differentiation and a dark outline of the tumor margin, making surgical removal ...Researchers offer proof-of-concept for Altered Nuclear Transfer
...ucleus, for example one taken from a skin cell, is implanted into a donor egg cell from which the nucleus had been removed. This egg cell is then tricked into thinking it has been fertilized. That causes it to grow into a blastocyst--a mass of about 100 cells--from which stem cells are removed. These embryoni...Cyberkinetics, Case to develop system to help restore extremity function
... is currently reviewing data from two participants implanted with the BrainGate System. The Cleveland FES Cente... the electrical activity of neurons. The sensor is implanted on the surface of the area of the brain responsible for movement, the motor cortex. A small wire con...Hair-raising stem cells identified
...rew them in culture for 140 generations. They then implanted progeny cells into the skin of newborn mice whose hair follicles were just being formed. This skin was then grafted onto athymic (nude) mice. Some cells were incorporated into developing follicles, but other follicles were completely made up of label...Ecologists spawn new use for PIT tags
...igrating fish. But rather than swimming out to sea implanted in young steelhead and salmon, thousands of passive integrated transponder, or PIT, tags were added to a clay simulant and then whipped around in tests of air sparger and pulse jet mixer equipment in large test tanks and scaled prototypes. This novel...It's electric: Cows show promise as powerplants
...ollected the fluid through a cannula, a surgically implanted tube that leads directly from the cow's hide into its rumen. The cow used in the study ate a normal diet. The researchers filled each of two sterilized glass chambers with strained rumen fluid to create the microbial fuel cell. Each chamber was about...Microchip saves rare turtle from soup-pot
... to a Chinese soup-pot, thanks to a tiny microchip implanted in its skin, according to experts from the New York-based Wildlife Conservation Society (WCS), who rediscovered the species four years ago in Cambodia. Wildlife inspectors discovered the 33-pound (15 kg) turtle in a crate of confiscated wildlife in ...Nanotubes inspire new technique for healing broken bones
.... Pins or screws then hold the healthy bone to the implanted material. Grafts provide a framework for bones to regenerate and heal, allowing bone cells to weave into the porous structure of the implant, which supports the new tissue as it grows to connect fractured bone segments. The new technique may someday ...Researchers grow stem cells from human skin
...cells were seeded onto three-dimensional molds and implanted in mice, they maintained features consistent with ... tissues consistent with bone, muscle and fat when implanted in animals; now we need to test their function long term," said Soker. Soker said the cells have pot...Tiny zebrafish teaches researchers how to fight off a deadly cancer
...College of Medicine, showed that zebrafish embryos implanted with human metastatic melanoma cells provide molecular cues that suppress tumor development. Hendrix is president and scientific director of the Children's Memorial Research Center, professor of pediatrics at Feinberg and a member of the executive ...