Fungus knocks a frog down but not out, raising questions about amphibian declines
...tidis appears to be especially lethal, having been implicated in massive declines and waves of extinction in Central America and Eastern Australia. A report published today in the October 4 issue of The Public Library of Science, includes findings that may give important new clues concerning this pathogenic ...Protein energy profiles offer clues about amyloids
...olding energies of proteins that have already been implicated in specific diseases. She believes the profiles could offer new clues to doctors and drug companies about which proteins are good candidates for drug therapy. Clementi co-authored the latest study with graduate student Silvina Matysiak. Two other gra...NIH awards Emory and Georgia Tech $10 million for partnerships in cancer nanotechnology
...d cell death; genes such as the p53 gene, which is implicated in many kinds of cancer; and microtubules and molecular motors, which are involved in transporting the proteins in cells that regulate cell growth. "These grants serve to highlight the importance of the partnership between Emory University, Georgia ...Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry
...pment, and helps maintain the immune system. It is implicated in a number of diseases as well, including cervical cancer caused by the human papilloma virus. Because it is involved in the body's inflammatory response to invading microbes, it may also play a role in autoimmune diseases. Hershko has been a sum...Embryonic stem cells correct congenital heart defect in mouse embryos
...ue, the authors identified two important molecules implicated in signaling from the ES cells to the Id knock-out... of the family of WNT proteins. Both molecules are implicated in heart development and cancer. The authors demonstrated that IGF-I injected into the mother can cr...Coke versus Pepsi: It's all in the head
...rtex" and the hippocampus. Both of these areas are implicated in modifying behavior based on emotion and affect. In particular, wrote the researchers, their findings suggest "that the hippocampus may participate in recalling cultural information that biases preference judgments." The researchers concluded that ...Time-lapse movies show brain cells move like a two-stroke engine
...g. In addition, problems with the cytoskeleton are implicated in human disorders in which nerve cells fail to migrate properly, such as Miller-Deiker syndrome. But no one had previously watched the cytoskeleton in living neurons in real time. The researchers took a new type of fluorescent dye called Venus, whic...Sniffing out the culprits of dust allergies
...ry. As a result of this investigation, Der 1 p was implicated in the cleavage of the CD4+ T cell receptor CD25--the Der 1 p inhibitor has a dose-dependent ability to protect the receptor on whole cells. This study demonstrates the utility of this new approach for quickly identifying active proteases involved in...Scientists identify new cause of obesity
...ls or hormones, and mutations in the receptors are implicated in many diseases. The new research provides the first evidence of an essential role for the basal activity of a GPCR in controlling a normal human physiological function, the scientists report. "Our genetic findings highlight the importance of patien...Gene for common form of Parkinson's pinpointed
...ion. "Because phosphorylation of proteins has been implicated in the pathogenesis of neurodegenerative disease, it is particularly tempting to hypothesize a role for dardarin in the phosphorylation of proteins central to PD..." wrote the researchers. Coro Paisn-Ruz, Shushant Jain, E. Whitney Evans, William P. G...Calorie restriction leads to some brain benefits but not others in mice
...eir young counterparts, particularly in one region implicated in Parkinson's disease, called the substantia nigra. But calorie-restricted old mice did not. "For the last 20 years there have been studies that suggest free radicals, particularly superoxide, are involved in cumulative damage with aging and that th...Pesticides may promote Parkinson's disease and exercise may offer protection
...n the process that leads to the death of the cells implicated in the control of movement by interfering with the programmed cell death process." Przedborski intends to confirm this role for the COX-2 protein by investigating whether the intensity of cell death increases in mice that possess an excess of COX-2 ...Cars, not crops, should be chief targets in reducing greenhouse gases
...rassland or forests. Carbon dioxide has been implicated in global warming because it can trap heat in the atmosphere much like a greenhouse. "We emit a quarter of the world's carbon dioxide emissions into the atmosphere, even though we constitute only 5 percent of the world's population," said Jacks...Stress impairs thinking via mania-linked enzyme
... cascade of events that trigger PKC have also been implicated in schizophrenia. Amy Arnsten, Ph.D. and Shari Birnbaum, Ph.D. of Yale University, and Husseini Manji, M.D., of NIMH, and colleagues, report on their discovery in the October 29, 2004 issue of Science. "Either direct or indirect activation of PKC dr...A new target for control of obesity
...It is present in each cell type in the body and is implicated in a variety of growth factor or cytokine pathways present in these cells. The physiological function of Shp2 is largely unknown. Whether it is active in multiple pathways or focused on a single pathway remains to be seen. In recent years, in v......epping Stones Human-modified landscapes have been implicated worldwide as a primary cause for the loss of native flora and fauna. Corridors and stepping stones have been proposed as strategies to increase landscape connectivity for fragmented populations. However, animals also move through the matrix, or habi...Neuronal excitability may hold key to age-related decline in learning and memory
...e have been numerous studies in the past that have implicated age-related changes in two neuronal attributes: a decrease in neuronal excitability, or the ability of neurons to be stimulated to fire, and age-related deficits in synaptic plasticity, or the ability of neurons to change some types of connections to...Signal for inflammation linked to Ras-induced tumor growth
... inflammation. The protooncogene Ras has also been implicated in tumor-driven blood vessel generation. Ras is abnormally activated in nearly one quarter of all human cancers and is involved in many aspects of tumor progression, including interactions between tumor cells and the surrounding environment. However,...New findings may redirect strategies for treatment of prostate cancer
... members EGFR and HER2. Previous work has strongly implicated EGFR as being a key modulator of AR. Interestingly, the Sawyers group found that HER2, but not EGFR signals, were required for optimal AR function. HER2 was shown to promote AR stability and function, not via interactions with EGFR, but by associatin......ssue known as muscle atrophy. Earlier studies have implicated three proteins NF-kappaB, p50, and Bcl3 in the development of atrophy, however the precise mechanisms involved have remained unknown. In the November 15 issue of the Journal of Clinical Investigation, Susan Kandarian and R. Bridge Hunter from Bosto...