B cells are required for development of epithelial cancer associated with chronic inflammation
...due to chronic inflammation. Previous studies have implicated an interaction between adaptive immune cells, like B lymphocytes, and innate immune cells during chronic inflammatory diseases. Dr. Lisa M. Coussens and colleagues from the Cancer Research Institute at the University of California at San Francisco us...Scientists identify genes responsible for 'black rot' disease in vegetables
...o functionally characterize Xcc and identify genes implicated in its pathogenicity, the researchers then screene..., the researchers identified three genes that were implicated in pathogenicity but that were not present in the previously described Xcc genomic sequence. To tes...Researchers develop assay that could be applied to drug screening
...rve cell junctions. Mis-regulation of CME has been implicated in some types of cancer and neuro-degenerative disease and the protein machinery of CME has been co-opted by several viruses, including rabies, as a means of entry into healthy cells. The researchers led by David Zenisek, assistant professor in the D...Joslin Diabetes Center scientists find 'brown fat cells' hold clues for possible obesity treatments
... diabetes. Being overweight or obese has long been implicated with insulin resistance and type 2 diabetes and also raises the risk for heart disease, stroke and cancer. The Joslin team studied "knockout" cell lines of brown preadipocytes that lacked insulin receptor substrates (IRS) numbered 1 through 4, which...New understanding of DNA repair may pave way to cancer treatments
...the first time we've seen a protein which has been implicated in gene regulation possess an independent function--in DNA repair--while both functions are uncoupled from one another," said Ronai. Dr. Ronai's laboratory has been studying ATF2 with the goal of understanding its role in regulation of cell cycle and...Other highlights in the June 1 JNCI
...ol, particularly deoxycholic acid (DCA), have been implicated in the pathogenesis of colorectal cancer. Preclinical research and early-phase trials have indicated that treatment with UDCA, which suppresses many of the biological pathways turned on by DCA, is associated with a reduced incidence of colorectal neo...Water quality a major focus of $14 million grant to the University of Arizona
...ptable levels of the contaminant. Arsenic has been implicated in skin and bladder cancer, vascular disease, heart defects in newborns and diabetes. Arsenic can be filtered out of water. However, used arsenic-laden filters pose a waste disposal problem. If such filters are dumped in a landfill, the microorganism...A radical solution for environmental pollution
...---highly reactive chemical species that have been implicated in aging, diseases such as Alzheimer's and cancer, and even destruction of the ozone layer---aren't all bad, Marsh said. Many essential chemical reactions occurring in living organisms involve enzymes that use radicals. In the work described in the J...Studies reveal how cells sense oxygen
...rlier report by the studies' senior authors, which implicated mitochondria as potential oxygen sensors. That report had remained controversial because experiments designed to test the idea by limiting mitochondrial function with nonspecific drugs yielded conflicting results. pages 393-399. DOI 10.1016/j.cmet.2...Unweaving amyloid fibers to solve prion puzzles
...w disease. But even though amyloids are common and implicated in a host of conditions, researchers haven't been able to identify their precise molecular structures. Conventional techniques used to image proteins, such as X-ray crystallography and nuclear magnetic resonance imaging, don't work with fibrous struc...Joslin scientists confirm link between PKC enzyme and kidney disease in diabetes
...ter have investigated PKC-beta - a critical enzyme implicated in the devastating complications of type 1 and type 2 diabetes - for more than two decades. Their latest research, to be presented June 11 at the American Diabetes Association's (ADA) 65th Scientific Sessions in San Diego, Calif., confirms the link b...Engineered skin offers clues to melanoma development
...ng clues to the oncogenic potency of several genes implicated in the development of melanoma. Melanoma is the de...am looked at the PI3K and Raf pathways, frequently implicated in the development of melanoma. They found the expression of active PI3K, together with CDK4, hTERT,...Scientists streamline method for making key virus
...hat causes common warts, genital warts and that is implicated in prevalent cancers -- scientists have paved the way for making the pathogen far more accessible to biomedical science. The work, reported today (June 13) in the online edition of the Proceedings of the National Academy of Science (PNAS), promises t...Millennium Ecosystem Assessment: Many of 2 billion dryland dwellers at risk as land degrades
...rom (the Gobi desert) and the Sahara has also been implicated in respiratory problems as far away as North America and has affected coral reefs in the Caribbean." The report shows infant mortality in drylands in developing countries averages about 54 children per 1,000 live births, 10 times that of industrial ...UQ among world leaders in schizophrenia research
...hromosomal regions, as well as several other genes implicated in worldwide research. Through this and subsequent research, Dr Mowry anticipates that genes which play a role in the development of schizophrenia will be identified within the next five years....Purdue scientists may have found key to halting spinal cord damage
...s vicious cycle. Because acrolein has already been implicated in cancer and neurological diseases, drugs that detoxify it could become important for treating not only spinal cord damage but a host of other conditions as well." The research, which Shi carried out with his student Jian Luo and Koji Uchida of Japa...Scripps research scientists solve structure of a critical innate immune system protein
...teps toward improving human health, since TLRs are implicated in a number of diseases and, hence, constitute potential therapeutic targets. Innate Immunity and Toll-Like Receptors Humans, like all other organisms, are constantly challenged in a world filled with microbial pathogens. We are bathed in bacteria,...Nerve protector could make for new stroke treatments
...ise in levels of nitric oxide, a gaseous substance implicated in stroke and degenerative diseases. Once activated, MMP-9 begins to break down structures in the nerve cell, leading to damage and disease. Lipton and his team believe that SB-3CT or similar drugs, if proven effective in further studies, may be ab...Forsyth scientists find three bacteria associated with oral cancer
...acteria, such as H. pylori, for example, have been implicated in augmenting the development of certain cancers). The Forsyth approach, which focuses on testing saliva for particular bacteria, differs from --and could complement-- another recently reported approach in which saliva would be monitored for evidenc...Scientists uncover new clues about brain function in human behavior
...ted in the front part of the brain, that have been implicated in decision-making, representation of social knowledge, and judgment. Those regions are the dorsolateral, the medial, and the orbitofrontal cortex. Specifically, the dorsolateral area is thought to establish and maintain social goals governing an int...