Pairing nanoparticles with proteins
... that gold nanoparticles might also be tailored to inactivate this enzyme complex, thereby thwarting drug-resistant TB -- a research avenue they may explore in future studies. In another part of the study, the researchers used proteins found on the surface of adenovirus, a virus that causes the common cold. P...Support for chromosomal theory of cancer found in cancers' development of drug resistance
...ny cell functions, leading to resistance, or could inactivate or damage the doors through which a drug enters a cell. Duesberg counters that aneuploidy is simpler and can explain the common development of resistance to many unrelated drugs within the same cancer. He has shown in experiments that aneuploidy ca...Exploring the dark matter of the genome
...he heterochromatin, which seek out transposons and inactivate them. That's the kind of knowledge that comes from sequencing heterochromatin." Smith uses the metaphor of dark matter to suggest the significance of heterochromatin. "We don't know what holds the galaxies together, and the same is true of the gen...Pediatric cancer stem cell identified: understanding the origin of ERMS
...rgeted chemical genetic approaches to specifically inactivate cancer pathways we have identified in our study. Identifying drugs that inactivate these pathways in theERMS cancer stem cell may have far reaching implications for treatment of patie...Researchers create model of cancer-preventing enzyme, study how it works
...y proline dehydrogenase and the molecules that can inactivate it. They also plan to examine another protein they suspect works in collaboration with proline dehydrogenase to understand how that protein affects the cancer-preventing abilities of proline dehydrogenase....Deactivating protein may protect nerve fibers in MS
...e study's lead author. "While we can't genetically inactivate cyclophilin D in people, there are drugs out there that can block the protein. Our research predicts that drugs that block cyclophilin D should protect nerve fibers from damage in MS." Such a drug would be the first therapy specifically for seconda...A genetic 'gang of 4' drives spread of breast cancer
...ssagu. "This really nailed the case that if we can inactivate these genes in concert, it will affect metastasis," he said. Massagu said that while clinical trials of the drug combination are being discussed, "there are already treatments to diminish the chance of metastasis in breast cancer, so such trials woul...Harvard team creates spray drying technique for TB vaccine
...ess on the bacterial membrane with great force and inactivate the bacteria. By removing these, we managed to save the bacteria and achieve better stability." The spray drying process developed for the BCG vaccine is similar to the way manufacturers prepare powdered milk. In fact, Edwards' first exposure to th...Are some people immune to avian flu?
...ples from 38 human volunteers for their ability to inactivate neuraminidase from an H1N1 virus and two H5N1 viruses. Most of the samples were active against the protein from the H1N1 virus; and 8 or 9 also inhibited the protein from both H5N1 viruses. The results indicate that a vaccine containing huN1 makes ...Fighting influenza and co. with 40,000 blood samples
...ive is also to develop new medicines which largely inactivate the viruses and enable the immune system to deal with the small amount of residual viruses. Spanish flu took the lives of at least 25 million people between 1918 and 1920. But the disease was not only exceptional because of its extreme virulence. T...Tips from the Journals of the American Society for Microbiology
... Norovirus in Foods High pressure processing may inactivate human norovirus strains in foods say researchers f...ment differing in pressure range was sufficient to inactivate the virus at a variety of temperatures, however, researchers found that inactivation was enhanced wh...... present in blood to bind glutamate chemically and inactivate it, effectively lowering levels in the blood and kicking transporter activity into high gear. In their experiments, Teichberg and his colleagues used this method to scavenge blood glutamate in rats with simulated traumatic brain injury. They found ...Plants point the way to coping with climate change
...e UK plants only need four weeks of cold to stably inactivate FLC, allowing plants to start their spring flowering early. Arabidopsis plants in Sweden have a mechanism that requires 14 straight weeks of winter cold before FLC is stably inactivated. This prevents the plants flowering only to be hit with another ...MGH Cancer Center researchers find new gene associated with Wilms tumor
...ms patients, so it takes a single genetic event to inactivate WTX in either males or females. That's in contrast to other tumor suppressor genes, which only can be inactivated by independent mutations affecting both copies of the gene." The researchers also found that WTX is expressed in cells involved in em...Epigenetic drugs, promising for breast cancer treatment
...hese two alternative ways that tumour cells use to inactivate tumour suppressor genes is that, while the reversal of genetic alterations is technically almost unfeasible in clinical scenarios, the function of these epigenetically inactivated suppressor genes is easily reactivated by pharmacological means. In th...Peering into the shadow world of RNA
... non-coding forms of RNA that appear to target and inactivate particular sets of messenger RNAs, thus preventing them from producing protein and effectively silencing the group of genes from which they were transcribed. In that study, Nishikura found that that precursor miRNAs, like messenger RNAs, are themselv...Tailored treatments: Promising designer drug provides new insight into cancer biology
...737 by using varied approaches that destabilize or inactivate MCL-1. Dr. Huang's group concludes that ABT-737 should be effective against tumors that exhibit BCL-2 overexpression and low MCL-1 levels or when used in combination with MCL-1 inhibitors. "The mechanistic insights provided here suggest ways in which......es, Li's team discovered is that imatinib does not inactivate all BCR-ABL signaling pathways in the cascade. Part of the cascade, proteins called SRC kinases, are still activated by BCR-ABL in imatinib-treated mouse leukemic cells. When Li treated the mice with a compound, dasatinib, that inhibits the SRC prote...Antioxidants: New kid on the block for pain relief?
... constantly produce free radicals, healthy tissues inactivate these damaging substances and keep their levels in check. It's when free-radical production somehow exceeds the body's natural defenses that problems occur. Researchers have linked this excessive production to diseases like cancer and Alzheimer's. ...Friendly bacteria in alcoholic milkshake could fight food allergies
...in E (IgE). IgE is involved in immune responses to inactivate organisms that might cause disease. However, in the presence of allergens it can also activate cells responsible for the release of histamine, a chemical which stimulates allergic responses, such as inflammation and constriction of airways. Ji-Ruei...