OHSU scientists identify key gene that delays female puberty
... they determined that expression of the TTF-1 gene increases in the hypothalamus of nonhuman primates at the onset of puberty. To conduct this latest research, Ojeda and his colleagues teamed up with Shioko Kimura, Ph.D., at the National Institute of Health's National Cancer Institute to study mice in which th...Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
...ter distance. Conversely, enhanced internalization increases Fgf8 uptake and shortens its effective signaling range. These new results suggest that growth factors are able to spread extracellularly by a diffusion-based mechanism. An especially important implication of the work is that target cells can actively...Emory study details dolphin brain evolution for the first time
...and narwhals) by about 15 million years ago. Both increases probably relate to changes in social ecology (the animals' social lifestyle) as well, Marino says. In addition to their large brains, odontocetes have demonstrated behavioral faculties previously only ascribed to humans and, to some extent, other gr...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...owed removing a group of proteins, known as Homer, increases glutamate receptor of the nerve cell surface in the subthalamic nucleus. This finding potentially explains how this area of the brain becomes overactive in Parkinson's disease. (2 pm 3 pm) observed how the pedunculopontine tegmental nucleus (PPT),...Humans and dolphins: If brain size is a measure, we're not that different
...as and narwhals) about 15 million years ago. Both increases probably relate to changes in the animals' lifestyles. Odontocetes have demonstrated behavioral faculties previously only ascribed to humans and other great apes. These abilities include mirror self-recognition, the comprehension of artificial...Warning from new SLU research: Usual test for vitamin deficiency can mislead doctors
...levels of MMA, a natural compound in the body that increases when B12 is lacking. "The usual way of diagnosing B12 deficiency may be inadequate because it underestimates the frequency of the problem, which is present in up to 20 percent of the elderly," Thomas says. "The problem is eminently treatab...Diabetic damage to eyes, heart, nerves, kidneys may be explained by controversial theory
... Scientists have known for some time that diabetes increases transformation of NAD to NADH by boosting cells' consumption of glucose through a process known as the sorbitol pathway. Like glycolysis, the sorbitol pathway transforms NAD to NADH, but only at a small fraction of the level of glycolysis. ...Research to explore revolutionary gene sequencing: Threading the molecular needle
...rrent sequencing technology. "With increases in technology, there is no reason that you couldn't read bases in microseconds, in which case you could get the time for sequencing the whole human genome down to hours," he said. The first sequencing of the human genome, completed in 2...VYTORIN (TM) superior again to Lipitor at lowering LDL (bad) cholesterol
...g and 10/80 mg also provided significantly greater increases in HDL ("good") cholesterol of 9 percent and 8 percent respectively as compared to the HDL cholesterol increase of 4 percent and 1.4 percent respectively seen in patients taking Lipitor 40 mg and 80 mg (p Study showed VYTORIN was well tolerated and ...'Broken' gene reveals evolution of salt retention and possible ties to hypertension
...by the non-functioning protein, and that advantage increases with latitude." "This could change the way we look for disease genes," she added. "Historically, we have searched for mutations, altered or damaged versions of genes that cause rare disorders, like cystic fibrosis or phenylketonuria. Now, we are st...Antibiotic-resistant bacteria increased after clindamycin use for common vaginal infection
...treated with clindamycin experienced more frequent increases in bacterial concentrations of E. coli than those who were treated with metronidazole. In addition, women treated with metronidazole showed more significant decreases in concentrations of other bacteria such as P. bivia, pigmented Prevotella spp and ...Research confirms that vCJD prions can be removed from blood
...sion-transmitted vCJD. The possibility of further increases in the number of human cases is of an uncertain magnitude, and the adverse impact that current donor deferral measures has on availability of the blood supply creates a serious public health issue" says Eric Krasnoff, Chairman and CEO, Pall Corporati...Look at past sea-level rise points to troubling future
...s. The findings are significant because half-meter increases are within the moderate range of predictions for t...out 20 percent slower than the projected sea level increases along the Texas and Louisiana coasts this century." Scientists know from oceanographic records that ...International marine survey of coral death
...to disease? How do environmental stresses, such as increases in water temperature and nutrients, affect coral immunity? And, ultimately, can new knowledge about coral disease inform science-based policy making? Project leaders say intensive research during the past decade has produced insights to the role o...Young adults who maintain their weight have lower risk factor levels for heart disease
...olic syndrome is a clustering of risk factors that increases a person's risk of heart disease. After 15 years, only 3.6 percent of the study participants who had maintained their weight had developed metabolic syndrome, compared to 18 percent of those whose weight had increased. "Young U.S. adults have a ma...Global warming's impact on US plants, animals determined from review of dozens of studies
...r 48 states, some parts of Alaska have experienced increases of up to 7 degrees Fahrenheit. The larger the change is, the fewer species are expected to be able to biologically adjust to the new conditions. "With warming for the next century projected to be two to 10 times greater than the last, we're heading ...Head movements by warblers could reveal basis for birds' geomagnetic sense
...s' head, and the fact that head-scanning frequency increases significantly when birds cannot detect the field can be used as a new method to determine the limits of the birds' magnetic sense: the researchers can expose the birds to a specific magnetic field and ask the birds whether they can sense the field. I......ce to the ground and bounce back up again and also increases the chances of injury. The team has also found that fast horses can bring their legs forward quickly in preparation for the next stride but that this is more difficult and therefore slower for large and long-legged horses." Using portraits of Ecli...Award will help unlock mysteries of one of Earth's most important organisms
...tand how changes in the environment translate into increases or decreases in phytoplankton abundance. For example, a research article in the Oct. 1 edition of the journal Science , of which Armbrust was the lead author, describes the first ever genomic sequence of one species of diatom, a kind of phytoplankt...Declining fish supply linked to wildlife consumption in West Africa, Science study reports
...lines in fish supply in Ghana can lead to regional increases in the hunting, trade and human consumption of wil...h supply the scientists cite are largely caused by increases in human population size. Fish catches have increased during the study period due to greatly expande...