Research uncovers role of Apolipoprotein E in Alzheimer's disease
...shed in the Neurobiology of Aging, the researchers indicate that the process of altering AB from its diffuse form into filamentous amyloid is needed to damage nerve cells in parts of the brain controlling memory and cognition. Mice with Alzheimer's disease showed memory deficits only when the ApoE gene was p......nwinding to see if it has cross-walls. "That would indicate it is related to the tubes," Xiao said. "These organisms lived 600 million years ago before big animals. This the very first moment of animal evolution preserved in the fossil record." The research, "Animal Embryos from the terminal Neoproterozoic D...Hurricane Ivan helps student study sinkholes
...s.") to determine if such sinkhole characteristics indicate what is happening underground. He is using a geophysical technique called electrical resistivity. Current is passed through the soil using a car battery attached to two electrodes embedded in the soil. By using an array of 25 embedded electrodes, and...JCI table of contents November 1, 2004
...broblast and collagen matrix. Together, these data indicate that SEMA3F is a strong inhibitor of metastasis that affects both tumor and stromal cells, which suggests that it may have therapeutic potential. TITLE: Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulate...Study reveals genetic link to colon cancer
...a specific gene in some patients with colon cancer indicate a risk of acquiring the disease. The study appears in the Nov. 3 edition of the Journal of the National Cancer Institute. The research team, led by Dr. Steven Gallinger used a population based study to determine that when one parent had the MutY huma...Crucial evolutionary link points to origins of modern cells
...out. "Moreover, we also believe these similarities indicate that NPCs and vesicle-coating complexes likely originated from a common ancestor." The research published in PLoS Biology represents the first stage of an overall analysis of the NPC structure by the Rockefeller scientists. "W...Link between immune protein and longer survival in melanoma patients identified
...to find and eradicate tumors. "This data may indicate that early melanoma vaccination is essential, and that vaccines inducing specific T cells with tumor-homing ability can make a significant difference in survival," said study co-author Irene Mullins, an instructor in the Department of Health Evaluati...Young adults who maintain their weight have lower risk factor levels for heart disease
...od pressure, high glucose (sugar) levels which can indicate risk for diabetes, high triglyceride levels, low levels of good cholesterol, and a large waist. Metabolic syndrome is defined as having at least 3 of these risk factors. Investigators found that on average as body mass index, an indicator of obesity...Neuronal excitability may hold key to age-related decline in learning and memory
...he enhanced learning effect. The new findings indicate that interactions between neuronal excitability and synaptic plasticity play a role in learning and that manipulations of either of these two parameters could be effective in ameliorating age-related cognitive decline. ...Elevated inflammatory enzyme, Lp-PLA2, significantly linked to ischemic stroke
...involved in atherosclerosis that can independently indicate risk of cardiovascular disease. Atherosclerosis, the underlying cause of heart attacks, strokes and peripheral vascular disease, accounts for 50 percent of all deaths in Western countries. Atherosclerosis involves inflammation within the walls o...Study links polycystic ovary syndrome with early vascular changes of heart disease
...inical Endocrinology and Metabolism. "Our findings indicate a strong correlation between PCOS, metabolic cardiovascular syndrome and initial evidence of calcium deposits that signal blood vessel disease," said Evelyn Talbott, Dr. P.H., professor of epidemiology and communication science at the University of P...Ancient marine invasion sheds light on diversity
...es was situated on the equator. The rock deposits indicate that the temperatures were increasing on a regional scale, just prior to a significant interval of global cooling. "We want to see how changes in the environment and temperature can affect the distribution of species," says Patzkowsky. "We are only...Reassuring findings from first study on sperm donor identification
...y meet each other. "What this study has done is to indicate that when youth are told of their conception origins early and have the option to learn more about their donor when they reach adulthood, they express a normal, healthy curiosity about the donor that reflects an interest in learning more about themse...By impounding iron, FHC foils cell suicide, fuels inflammation
...al steps toward programmed cell death. "The data indicate that the antioxidant activity of FHC involves iron sequestration and that this sequestration is crucial for suppression of death of white blood cells induced by proinflammatory factors," the authors note. These findings identify FHC as the mechanism...Brain-derived neurotrophic factor (BDNF) appears to modify elements of alcoholism
...ic factor (BDNF) on the dopamine system. Findings indicate that variants of the BDNF gene may not only play a... (variant) of the BDNF gene was genotyped. Results indicate that genotype and allele distributions of the BDNF gene polymorphism did not differ significantly be...JCI table of contents, November 15 2004
...oint to the importance of PAR1 activity in IBD and indicate that PAR1 inhibition may be useful in treating IBD and other chronic intestinal inflammatory conditions. TITLE: A role for proteinase-activated receptor-1 in inflammatory bowel diseases. AUTHOR CONTACT:Nathalie Vergnolle Department of...New fossil may be closest yet to ancestor of all great apes
... and Afropithecus , but the fossils that do exist indicate that these ancient "hominoids" were more primitive...ved together, but Pierolapithecus ' short fingers indicate that it didn't do a lot of hanging. Hanging-related traits may have evolved several times, showing u...Hold the stuffing: Low-glycemic diet may help keep weight off
...a meal rather than limit fat intake. The findings indicate that a low-glycemic diet may overcome the body's natural tendency to slow metabolism and turn on hunger cues to "make up" the missing calories. The low-glycemic-load (low-GL) diet reduces carbohydrates that are rapidly digested and that raise blood s...Studies in Royal Society journals include stress in birds and depletion of medieval fish stocks
...hirp rate, two components of the calling song that indicate male nutritional condition during juvenile develop...r frequency over the chirp rate. Thus, our results indicate that females integrate information from distinct cues when choosing a mate. Contact: Dr MWG Brinkhof...Global assessments of biodiversity argue for expansion of protected areas in key regions
...each of the international community." The findings indicate "the need for rapid action to mobilize significant new resources for the developing world's protected areas." ...