Protein 'chatter' linked to cancer activation
.... Disruption of this communication in cancer cells induces shortening of chromosome ends and may restrict their potential to grow. Zhu says that the discovery will help researchers understand the onset and progression of these diseases as well as help them find a cure for cancer. ...Learning to evolve: With a little help from my ancestors
...econd, learning in previous generations indirectly induces the formation of a latent memory in the current generation, and therefore decreases the amount of learning required. It matters how quickly learning occurs, because time spent learning is time spent not eating, or time spent being eaten, which incurs...JCI table of contents: July 19, 2007
...ockout of PCK-lambda impairs glucose transport and induces metabolic and diabetic sydnromes AUTHOR CONTACT: Robert V. Farese University of South Florida College of Medicine, Tampa, Florida, USA. Phone: (813) 972-7662; Fax: (813) 972-7623; E-mail: rfarese@health.usf.edu View the PDF of this article at......jury. Dr. Counters team has demonstrated that Ras induces the secretion of IL6 in a number of different cell types. The scientists then showed that IL6 promotes tumorigenesis by encouraging new blood vessel growth. Dr. Counter and colleagues were able to successfully fight tumor formation in a preclinica...Regulating alternative splicing during neural development
...w that a switch in expression between PTB and nPTB induces changes in a large number of alternative splicing patterns during neuronal development. "This reprogramming of splicing by the switch in PTB proteins adds a new layer of genetic change determining the function of a post-mitotic neuron."...UCF professor finds bacterial pathogen may be key to understanding cancer development
...the team found that a Listeria protein called InlB induces internalization and degradation of a human receptor known as Met. Met has been implicated in the development of some cancers. Lisa A. Elferink at the University of Texas Medical Branch led the team. She and Ireton found that the ability of InlB to...Weill Cornell team identifies potential new cancer drug target
... How XIAP inhibits caspases is known, but how XIAP induces NF-kappa B activation is entirely unclear. "We wondered if we could find out how XIAP induces the NF-kappa B pathway," explains lead researcher Dr. Miao Lu, a postdoctoral fellow of biochemistry...Scripps research scientists show protein accelerates breast cancer progression in animal models
...lls-cells found in the loose connective tissue-and induces several features of aggressive breast cancer. While the importance of these cancer cell-stromal cell interactions is well established, only limited progress has been made in identifying the factors that cause stromal cells to initiate tumor progressi...Tips from the Journals of the American Society for Microbiology
...s immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice. Infection and Immunity, 75. 6: 2826-2832). Respiratory Tract Immunization May Protect Against Ebola Virus A topical respiratory tract vaccine tested for the f...Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
...kdown. Silencing of these genes in many cases also induces polyploidy and multinucleation in the absence of drug treatment. The researchers conclude that specific disruption of the mitotic checkpoint promotes paclitaxel resistance and that chromosomal numerical heterogeneity may be a useful predictor of pacl...Researchers shed light on mechanism of action used by anti-cancer drug
...team found that in human leukemia cells, sorafenib induces a process known as endoplasmic reticulum (ER) stress, which results from accumulation of misfolded proteins in the ER. The ER is a subcellular structure which plays a key role in cellular protein disposition. When stressed in this way, the cell respo...Talcum powder stunts growth of lung tumors
... forming, slows cell growth and movement, and even induces nearby tumor cells to commit suicide. All of these make it hard for tumors to grow and spread into healthy lung tissue. When endostatin was first discovered in 1997, doctors hoped its tumor-fighting properties would lead to a cure for cancer. But c...Ethanol injection helps manage bone metastasis in thyroid cancer patients
...to the tumor," explained Nakada. "Absolute ethanol induces direct necrosis (cell death) of the tissue in the area where it is distributed. Therefore, if absolute ethanol is selectively injected into a malignant tumor, selective destruction of the tumor may be expected," he added. In their study, 12 patients ...JCI table of contents: May 24, 2007
...n type 2 diabetics. TITLE: Hypothalamic resistin induces hepatic insulin resistance AUTHOR CONTACT: Luciano Rossetti Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA. Phone : (718) 430-4118; Fax : (718) 430-8557; E-mail : rossetti@aecom.yu.edu View the PDF of this art...IMS updated recommendations on postmenopausal hormone therapy
...ometrial cancer Unopposed estrogen administration induces a dose-related stimulation of the endometrium. Women with a uterus should have progestogen supplementation. Continuous combined estrogenprogestogen regimens are associated with a lower incidence of endometrial hyperplasia and cancer than occurs in...Dinosaur hearing, listening to muscle noise, quieter cubicles
... leading indicator of malignancy. By contrast, VA induces a small-scale vibration in the tissue, and it is this low-frequency signal that provides the crucial information about tissue stiffness. Azra Alizad ( aza@mayo.edu ), who works at the Mayo Clinic, the pioneer in vibro-acoustography research, says th...Anthrax paralyzes immune cells with lethal toxin, UF research shows
...study actin because it commandeers human cells and induces them to form the filaments, which the bacteria use to navigate around the body. "We used one bacterium to weed out another. I'm not aware of anyone ever doing that," Southwick said. "In an individual cell, you can't figure out where the actin is as......h with increasing exposure to UV light. UV light induces the crosslinking of the constituent DNA bases within the polynucleotide chains, as well as causes the formation of lesions by linking together the adjacent strands. The small changes in structure induced by this crosslinking can very profoundly affec...Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
...dant effects in the normal cells, it paradoxically induces an oxidative stress in the tumor cells. It is possible that this differential effect of C-3-R may account for its selective toxicity in the tumor cells. According to Dr. Yin, these results indicate that C-3-R has the promising potential to be use...Bioluminescence at the service of a novel cerebral imaging technique
...r learning and olfactory memory in the Drosophila) induces a secondary response which is delayed by about 10 to 15 minutes at the level of neuronal axonal projections. It is therefore probable that this new response (hitherto totally unsuspected) intervenes in learning and memory phenomena. Furthermore,...