Universal flu vaccine being tested on humans
...nfluenza vaccine is the first example of a vaccine inducing a protective immune response that normally does not occur in nature, for example following infection by a virus or a bacterium. Clinical trials on humans Acambis - a biotech company that specializes in the development of vaccines - has been exclu...Specific type of cell death may accelerate decompensated heart failure
.... Researchers then tested the role of autophagy by inducing heart failure in mice with the varying autophagic responses. Mice with amplification of autophagy fared worse in terms of cardiac stress than the mice with a muted response, Dr. Hill said. Severe stress leads to increased autophagic activity in he...New clues to stroke role in Alzheimer's
...CE and the amyloid proteins. And they found that inducing strokes in rats caused GGA3 to be degraded and BACE levels to increase. Finally, when they analyzed brain tissue from people with AD, they found decreases in GGA3 levels that were inversely correlated with increases in BACE. The researchers pointed...Blocking beta1-integrin to treat cancer
...tastases by reducing tumour cell proliferation and inducing cell senescence. Integrins are a family of transmembrane receptors that help maintain tissue integrityby attaching cells to the surrounding extracellular matrix and preventing them from migratingaround. These proteins are also important for cell su...Research identifies protein that signals flowering in squash plants
...origen, is produced in the leaves of a plant under inducing conditions, and then is transported through the ph...ll remain in the vegetative state until and unless inducing conditions (such as long nights) occur, and therefore they represent the ideal system for experiment...Scientists identify prion's infectious secret
... Also, weve seen just one small part of this prion inducing proteins to fold. This is an entirely new concept." Earlier research from the Lindquist lab, published in Nature in 2005, identified the amino acid regions where prions connect with one another to form amyloids. Those interaction regions turn out...Minuscule molecules pack a powerful punch
... controlling the activity of other genes, often by inducing destruction of protein-coding messenger RNAs or by preventing their activity in the cell. The research team, led by the Wellcome Trust Sanger Institute, targeted a gene called Bic/microRNA-155 (or miR-155) in embryonic stem cells which they used to...Popular herbal supplement hinders the growth of pancreatic cancer cells
...tremely effective inhibitor of the cancer process, inducing apoptosis in cancer cells," said Sanjay K. Srivastava, Ph.D., lead investigator and assistant professor, department of pharmacology, University of Pittsburgh School of Medicine. "Triphala triggered the cancerous cells to die off and significantly red...Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
...directly or if they are acting on the membrane and inducing a cascade of events resulting in DNA damage," Pacheco said. "Once we understand the mechanisms by which nanoparticles induce their toxicity, we will be better able to prevent or mitigate their harmful effects." In the meantime, the experimental te...New therapeutic insight into duchenne muscular dystrophy
...hat are aberrantly inactivated in DMD. In fact, by inducing PGC-1alpha expression in these transgenic mice, the scientists were able to improve DMD symptoms. "These data clearly show that experimental elevation ofPGC-1 alpha has therapeutic promise in an animal model of Duchene's muscular dystrophy. We hope...AACR's Sixth Annual Landon Awards recognize Richard Kolodner, Douglas Lowy and John Schiller
...l of the HPV, the capsid proteins, were capable of inducing antibodies, which meant the capsid proteins could be used as both a serological test and a vaccine against HPV infection. Their ongoing research directly led to the first HPV vaccine, approved by the FDA in 2006, which has the potential to drastic...UNC scientists discover cellular 'SOS' signal in response to UV skin damage
...to certain types of cancer therapies which work by inducing the cancer cell to die. If the cell, even if it is a cancer cell, is given this additional time to recover from treatment, it may be able to survive it, much to the detriment of the patient." Kaufmann said. Ultraviolet radiation in sunlight causes...Mechanisms involved with tumor relapse identified
...types of immune responses in patients, rather than inducing a broad range of immune responses - some of which may be detrimental or may induce tumor relapse," said lead investigator, Masoud H. Manjili, D.V.M., Ph.D., a member scientist with the Massey Cancer Center. "Ultimately, we hope to offer a new polyp...Therapeutic peptide frees the protein p73 to kill tumor cells
...otein p53 suppresses tumor development by potently inducing tumor cell death, making it an obvious target for anticancer therapeutics. However, this therapeutic approach is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50% of human cancers. As the p53-related...JCI table of contents -- March 8, 2006
...otein p53 suppresses tumor development by potently inducing tumor cell death, making it an obvious target for anticancer therapeutics. However, this therapeutic approach is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50% of human cancers. As the p53-related...How eating less might make you live longer
...aging is that it lowers free-radical production by inducing the formation of efficient mitochondria. Civitarese and colleagues enrolled 36 healthy overweight but non-obese young people into their study. A third of them received 100% of their energy requirements in their diet; the caloric restriction (CR) gr...Studies force new view on biology of flavonoids
... of gearing up to get rid of unwanted compounds is inducing so-called Phase II enzymes that also help eliminate mutagens and carcinogens, and therefore may be of value in cancer prevention. "Flavonoids could also induce mechanisms that help kill cancer cells and inhibit tumor invasion," Frei added. It als...Sphingolipids with therapeutic ends
... is to apply them in an animal model, for example, inducing atherogenesis and trying to solve the problem in the whole organism using sphingolipids....Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
...ate how big a role greenhouse gases have played in inducing global warming," said Donahue. "Moreover, the new mechanism we found changes the chemical properties of particles, making them more likely to participate in cloud formation. Therefore, particulate matter may be having a stronger influence on global c...A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
... the featured article also presents techniques for inducing mutations into the DNA of flies. The article will be useful for biologists starting to work with flies in the laboratory, as well as for existing fly laboratories looking to reorganize. Other articles published today include methods for harvesting ...