Cardiac patches stimulate regeneration, improve function after heart attack
... been incubated with periostin was placed over the infarct site; the others received Gelfoam only. Twelve ... had less scarring of heart tissue, a reduction in infarct size and a denser network of blood vessels feeding the area. In contrast, the rats receiving Gelfoam...News tips from the Journal of Neuroscience
...r protection. Mice pretreated with LPS had reduced infarct size after middle cerebral artery occlusion and showed improved cerebral blood flow in spared regions. This protection required nitric oxide (NO) produced by inducible NO synthase (iNOS) and superoxide produced by NADPH oxidase (nox2). Peroxynitrite,...Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
...icantly increased ischemia and reperfusion-induced infarct size in left ventricles and significantly affected post-ischemic recovery of left ventricular function in both male and female offspring. However, the effect of nicotine was significantly more pronounced in females than in males. Conclusions T...Administering stem cells to patients with myocardial infarction leads to a reduction of the infarct
...recovery: in the patients studied, the size of the infarct was clearly reduced. The use of stem cells appears...nfarctions. Moreover, the reduction of the size of infarct was significantly greater in all patients in the 'stem cell group' and correlates with a better pres...Fantastic voyage into the heart delivers a protector against heart failure
...tegy protected cardiomyocytes from injury, reduced infarct size, and preserved cardiac function. This effect could not be achieved by injecting nanofibers or PDGF-BB alone. These nanofibers represent unique biomaterials able to deliver therapeutic agents directly to the injured tissue and as such hold great ...JCI table of contents: December 15, 2005
...tegy protected cardiomyocytes from injury, reduced infarct size, and preserved cardiac function. This effect could not be achieved by injecting nanofibers or PDGF-BB alone. These nanofibers represent unique biomaterials able to deliver therapeutic agents directly to the injured tissue and as such hold great ...Bone marrow stem cells may heal hearts even years after heart attacks
... percent, and there was a significant reduction of infarct size by 30 percent. Concerning all those parameter...presents myocardial metabolism and viability, into infarct tissue was observed," Dr. Strauer said. "The stem cell therapy demonstrates that restoration is poss...Survival of heart patients on beta-blockers varies greatly with genetic variation
...ective. They are known to decrease the size of the infarct and seem to prolong survival, on average." Recent research, however, reveals that variations in the beta-adrenergic receptor genes affect the benefit of beta-blockers in heart patients. Data indicate that variations of the genes influence such parame...The promise of new medical uses for sodium nitrite for heart attack and organ damage
...ed the size of the area of dead tissue known as an infarct by 67 percent compared to control animals given nitrate, another nitrogen compound. This potent protective effect was observed at concentrations of nitrite in blood that were only slightly higher than the physiological normal levels in blood. The st...In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage
...itment of more highly activated neutrophils to the infarct zone during an acute MI, leading to significantly ...ies from the Van Scott-Lust laboratory showed that infarct size is increased after an acute MI in both rabbit and mouse models of asthma, with enhanced neutrop...New effects of an antihistaminic against cerebral injury
...ns when there is a cerebral ischemia) caused by an infarct or a traumatism. When a lesion of this type occurs...treatments always take place after the time of the infarct or traumatism. The authors of the research, recently published in Stroke magazine, affirm that the ...Acetaminophen shows positive in vivo cardioprotective effects in heart attack, arrhythmia
...ical agent provides, specifically by measuring the infarct size" in a simulated heart attack, according to Ga...found that acetaminophen significantly reduced the infarct size by 60% or more by three different key measurements in treated dogs, compared with a physiologic...