Tag: "inflammatory" at biology news
NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...itis and juvenile forms of myositis. Also known as inflammatory
myopathies, they are musculoskeletal disorders characterized by muscle weakness thought to be autoimmune diseases. This means that the bodys immune system, which normally fights infections and viruses, for reasons unknown turns on itself and attacks ...
Study begins to reveal clues to the cause and progression of sepsis
...ericans will develop sepsis, a result of the bodys inflammatory
response to an infection, which can lead to organ ...y understand the complexity and variability of the inflammatory
response to sepsis. To gain a better understanding into the mechanisms behind the condition, the res...
JCI table of contents: Aug. 9, 2007
...ne pathway of apoptosis activated by the sustained inflammatory
response the intrinsic apoptotic pathway of cell death. The extrinsic apoptotic pathway of cell death proceeded unchecked. These data led the authors to suggest that the extent of cardiomyocyte apoptosis is a critical factor in determining whether o...
Weizmann Institute scientists discover a control mechanism for metastasis
... tumor samples taken from around 300 patients with inflammatory
breast cancer, a rare but swift and deadly form of the disease, which is associated with elevated growth factor levels. The scientists found a strong correlation between high growth factor activity and levels of the 'plug' protein. High levels of thi...
Inflammation may cause preterm labor and fetal deaths
... two receptors as a possible link in producing the inflammatory
response that is believed to have brought about th...led Han and her colleagues to attempt to block the inflammatory
process by using synthetic TLR4 antagonist that prevented the receptor from sensing the bacteria. ...
Cornell scientists link E. coli bacteria to Crohn's disease
... Microbial Ecology. Crohns disease, an incurable inflammatory
disorder of the intestine most commonly found in ... specific bacterial characteristics that drive the inflammatory
response have remained elusive. Researchers at Cornell examined possible causes for the disease in ...
Penn researchers discover how key protein stops inflammation
...on for developing therapies to treat infectious or inflammatory
diseases, such as sepsis, diabetes, and rheumatoid...y be able to create an artificial way to block the inflammatory
response. In the laboratory of senior author Youhai Chen, PhD, Associate Professor of Pathology an...
MIT model could predict cells' response to drugs
...mental stimuli. The behavioral outcome-cell death, inflammatory
cytokine production, etc., was also measured. Using that data, they constructed a model correlating outcomes with the combined levels of activity in the multiple pathways. The model was then used to correctly predict what would happen to two other ...
JCI table of contents -- July 26, 2007
...- or Th2-type cells, and as such Th1- and Th2-type inflammatory
immune responses in the lung were also impaired. T...nd physiology. TITLE: SLAT regulates Th1 and Th2 inflammatory
responses by controlling Ca2+/NFAT signaling AUTHOR CONTACT: Amnon Altman La Jolla Institute f...
Effects of aging in stem cells
...blood cells. They found that genes involved in the inflammatory
and stress response became more active with age, w... stable. The finding that genes involved in the inflammatory
response are expressed more (called up-regulation) as HSCs age fits with evidence linking inflammati...
...ers milk. Ingestion of this toxic milk sets off an inflammatory
response in the skin of nursing pups, which ultimately disrupts the hair growth cycle and renders them largely bald. In fact, treatment with the common anti-inflammatory aspirin completely rescues hair loss in these pups....
'Preconditioning' helps protect brain's blood vessels from stroke
...a more toxic event occurs." Normal mice given an inflammatory
toxin called lipopolysaccharide (LPS) 24 hours before an induced stroke -- the preconditioning method used in this study -- had a 68 percent reduction in stroke intensity, the researchers found. Preconditioning also boosted blood flow in areas of ...
Mucins stand guard against gut infections
...ole of these proteins in epithelial infections and inflammatory
disease should be further examined. ...
JCI table of contents: July 19, 2007
...ole of these proteins in epithelial infections and inflammatory
disease should be further examined. TITLE: MUC1 ...self-glycolipid, sulfatide, and their relevance to inflammatory
liver disease. They show that activation of sulfatide-reactive type II NKT cells caused recruitment ...
Gene identified for Crohn's disease in children
...ts pile up within the cell, they may stimulate the inflammatory
response that characterizes Crohns disease. Although much research remains to be done, he added, better understanding of the disease process may guide doctors to new and improved therapies. If an excess of bacteria is the problem, we may find ant...
Crystal structure enables tailoring of pharmaceuticals against asthma
...ary tract. Asthma attacks are caused by an acute inflammatory
reaction in the airways, a reaction that is largely due to actions of LTC4 synthase. For this reason asthma medicines often aim at blocking the downstream effects of LTC4 synthase. However, there is a need for new pharmaceutical alternatives, since n...
Gene discovered for type 1 diabetes in children
... attention-deficit hyperactivity disorder, autism, inflammatory
bowel disease, hypertension, juvenile rheumatoid arthritis and the pediatric cancer neuroblastoma. The Center recently contributed 4,000 DNA samples to an industry-hosted database that serves as a free repository of control samples for researchers se...
...iving a lot attention. Interleukin-6 (IL6) is an inflammatory
cytokine (growth factor) that stimulates the immune system in response to injury. Dr. Counters team has demonstrated that Ras induces the secretion of IL6 in a number of different cell types. The scientists then showed that IL6 promotes tumorigenesi...
Small molecules may explain psoriasis
..., may play an important role in the development of inflammatory
skin diseases such as psoriasis and atopic eczema.... be significant in regulating other common chronic inflammatory
diseases such as arthritis and certain autoimmune diseases, says Andor Pivarcsi, who has directed th...
Fat horses face health problems
...y on the role of hormone levels, oxidative stress, inflammatory
biomarkers, and antioxidant mechanisms. However, the preliminary data clearly demonstrates that this research has important implications for both equine and human health. For example, the knowledge gained concerning the correlation between fortifi...
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