University of Cincinnati receives $1.7M to research molecular treatment of brain injury
...Ts. We believe eicosanoids reduce the number of inflammatory cells that fester around the injury site and cause chronic tissue degeneration, Strauss says. We think this plays a role in impairment not only after trauma, but also after other brain injuries, including strokes, seizures and the chronic neurodegene...Gene variations directly link inflammation to an increased risk for lung cancer
...ly strong among heavy smokers, suggesting that the inflammatory response is important in modulating the damage cau...ch damage to the lung might trigger an overzealous inflammatory response by the immune system, leading to lung cancer. The variants, or polymorphisms, were found ...Skin rash actually signifies better outcomes for pancreatic and lung cancer patients
... with treatment. They are believed to be due to an inflammatory response as a result of EGFR inhibition in skin tissue, Wacker said. The analysis looked at two placebo-controlled, double-blind, randomized, Phase III clinical trials testing Tarceva in advanced non-small cell lung cancer and pancreatic cancer - s...JCI Table of Contents -- July 2, 2007
...w that the chemokine receptor D6 acts to sequester inflammatory molecules known as chemokines and as such is essen...iversity in New York comments that if a heightened inflammatory state in the skin can influence p53 gain-of-function status, this may have important implications fo...p53 gene mutations and inflammation trigger skin cancer
...w that the chemokine receptor D6 acts to sequester inflammatory molecules known as chemokines and as such is essen...iversity in New York comments that if a heightened inflammatory state in the skin can influence p53 gain-of-function status, this may have important implications fo......ce. MIF has now been linked to many autoimmune and inflammatory diseases - such as diabetes and sepsis - and Al-A...on the MIF protein surface that is crucial for the inflammatory response. Such a substance designed to target this area could be used to treat a variety of conditio...Bisphosphonate treatment is associated with jaw bone problems
...relationship. Do bisphosphonates predispose toward inflammatory conditions of the jaw, some of which may or may not be osteonecrosis of the jaw" Or do patients with metastatic cancerexperience more episodes of dental infection and therefore require more oral surgical procedures" the authors write....Omega-3 fatty acids protect eyes against retinopathy, study finds
... occurs because these mediators suppress a type of inflammatory protein called tumor necrosis factor alpha (TNF-al... to identify modifiable factors that may influence inflammatory processes implicated in the development of common sight-threatening retinal diseases. These stud...Stem cell licensing deal positions Toronto as world leader in technology
... in cell therapy include combating auto-immune and inflammatory diseases (Crohns, juvenile diabetes and rheumatoid...elopment program designed to treat auto-immune and inflammatory diseases offers parents a type of biological life insurance that could one day treat all the disease...Researchers develop buckyballs to fight allergy
...ssues except blood. When mast cells are activated, inflammatory substances such as histamine, heparin and a number of cytokines are rapidly released into the tissues and blood, promoting an allergic response. The researchers found that the unique structure of the buckyball enables it to bind to free radicals dr...Fever after smallpox vaccination tied to individual genetic variations
...ne variation in IL-4, a gene that dampens down the inflammatory response, also reduced fever risk. Interestingly, studies in mice have shown that immune system molecules produced by the IL-1 and IL-18 genes are linked to tissue damage in viral myocarditis, raising the question of whether a more severe complicat...Inflammation is at the origin and progression of diseases such as diabetes or cancer
...ffected tissue. Asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, Alzh... the production of cytokines, proteins involved in inflammatory processes that end up promoting insulin resistance. There are currently several drugs in clinical te...Cytokine resistance contributes to pathology of type 2 diabetes
...lin uptake and/or cytokine signaling in a balanced inflammatory response. This study supports earlier findings that inflammation is a key part of the pathology of diabetes, Freund said. Pro-inflammatory cytokines are elevated in type 2 diabetes, but the anti-inflammatory mechanisms are also impaired, leading to...JCI table of contents: June 14, 2007
...environmental irritants or other agents that cause inflammatory pain. PARs, also present on neurons, are known to ...n TRPA1 and PAR2 may be useful in the treatment of inflammatory pain. TITLE: Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain AU...LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
...w therapeutic approach for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, colitis, ps... blood cell responsible for several autoimmune and inflammatory diseases. The finding is an important first step that, if eventually found to be true in humans, po...University of Washington researchers play leading role in major study of human genome function
... common diseases, like prostate and colon cancer, inflammatory bowel disease, arthritis, and diabetes. By having a complete map of functional DNA within the genome, biomedical scientists will be able to track down the causes of these diseases far more rapidly than before, and will be better equipped to treat or ...Breakthrough developments in rheumatoid arthritis reported
...at makes these people susceptible to the disabling inflammatory condition. Dr. Gregersen has finally closed th... or genetic variants, that are associated with the inflammatory condition and can be used to understand the triggers of the disease. This will provide key insights ...Identification of genetic risk factor for coeliac disease promises improved treatment
...ium investigating the genetic causes of intestinal inflammatory conditions has identified a new genetic risk factor for coeliac disease. The findings, published online today (10 June 2007) in the science journal Nature Genetics, could pave the way towards improved diagnostics and treatments for the common, lifel...University of Manchester researchers reveal clues to new genes behind rheumatoid arthritis
...d evidence of several new genes behind the chronic inflammatory disease rheumatoid arthritis (RA), which affects 3... are working to validate others. RA is a chronic inflammatory disease that can affect nearly all joints in the body, particularly the hands and feet. Complication...UCLA researchers discover novel pathway that may promote immune system balance
...nal Cell, may lead to new ways to fight cancer and inflammatory diseases, said Ke Shuai, a professor of hematology...ry genes, resulting in the prevention of excessive inflammatory responses. In cancer, the immune system can be mobilized to kill tumor cells, for example, the d...