September/October 2004 Annals of Family Medicine tip sheet
...primary care research is extremely valuable, it is infused with complexities and requires additional effort, administrative skill and patience. Prevalence and Predictors of Night Sweats, Day Sweats, and Hot Flashes in Older Primary Care Patients: An OKPRN Study By James W. Mold, M.D., M.P.H., et al A cr...Six reporters reach the 'Pinnacle of Excellence'
...f the twin Mars Exploration Rovers (M.E.R.). Davis infused the storytelling with the scientists' personalities, emphasizing the human drama of what went on behind the scenes. The program provides a private look at a public project and shows the decision-making process while it is happening. Radio Cynthia ...Don't count on vitamin C to boost your exercise performance
... of ingesting 500 mg daily of vitamin C or getting infused with acute amounts just before exercise, the blood results were surprisingly uniform between ages and sexes. Indeed, the only major difference found throughout the experiment was that "irrespective of age, MAC, MCO and heart stroke volume were greate...FDA approves ABRAXANE(TM) for metastatic breast cancer
... 2003). Despite a 50% higher dose of chemotherapy infused over 30 minutes without premedication for hypersensitivity, ABRAXANE was well tolerated in the pivotal Phase III trial. Neutropenia (all grades) was experienced by 80% of patients treated with ABRAXANE and 82% of patients treated with Taxol. Less...Chemical engineer Kao explores antibiotic synthesis with DNA chips
...m cultures of erythromycin-producing bacteria were infused with fluorescent dye and applied to the microarray. "This experiment revealed that the RNA transcript abundance of the erythromycin-producing genes remained higher for longer times in the Saccharopolyspora erythraea mutant strain," Kao said. Searchi...Cure no quick fix for cancer survivors on long road to recovery
...ation therapy used to treat cancer. After they are infused into the bloodstream, stem cells take up residence in the bone marrow, where they give rise to the immune system's infection-fighting white blood cells, red blood cells or platelets. Worldwide, about 100,000 people who have undergone a successful tra...Genetically modified natural killer immune cells attack, kill leukemia cells
...lly modified. These modified NK cells will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained from a patient while in remission and then reinfused after genetic modification if the patient suffers a resurgenc...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
... of the faulty enzyme in those with the disease is infused weekly. In clinical trials of the replacement therapy, the infusions have already prolonged the lives of many babies with Pompe disease, Koeberl said. "A number of babies have been receiving enzyme replacement therapy for several years," said Koeberl...Stem cells bring fast direct improvement, without differentiation, in acute renal failure
... rats with ischemic/reperfusion (I/R) ARF. Animals infused with MSC either immediately or 24 hours after reperfusion had significantly better renal function, lower renal injury and cell-death scores, and higher cell division indices than vehicle-treated control animals," the paper stated. Indeed, administrat...Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'
...heir average pain ratings per volume of salt water infused -- in other words, the placebo effect was strong. The other five were classified as "low placebo responders." These subjective ratings are consistent with previous findings, Zubieta notes. But the simultaneous imaging of the participants' endogenous ...Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease
...iral vector with a human GAD gene (cDNA) were then infused at 0.5 microliters/minute, together with 15 microliters of 25% mannitol. After the 100-minute infusion period, the delivery catheter was withdrawn and the incision closed. No hardware was left behind following this procedure, and all patients were...Bone marrow stem cells may heal hearts even years after heart attacks
... After processing, stem cells from the marrow were infused through a catheter into the coronary artery where the patient's heart attack occurred. "The main results were at least threefold: an improvement in global left ventricular function by 15 percent, infarction wall movement velocity rose 57 percent, and...Calls for improved screening of colorectal cancer in Europe's aging population at ECCO 13
...z regimen, is used extensively, whereas in Europe, infused 5FU is preferred. Irinotecan with the bolus FU/FA...n day 1 and 2, 5FU bolus 400 mg/m2 on day 1, 2 and infused 5FU 1 200 mg/m2 per 48 hour. Results from the study were presented, with investigators highlighting ...Brain plays key role in diabetes therapy
...e organ unable to produce insulin. The researchers infused the brains of the diabetic rats with a chemical that limits the function of an enzyme involved in the normal insulin response before injecting the animals with the hormone. Without the normal brain response to insulin, the hormone therapy's efficacy ...News tips from The Journal of Neuroscience
...-NG2 monoclonal antibodies (mAbs). Antibodies were infused into the spinal cord over several days from gelfoam pledglets. In rats treated with non-neutralizing mAbs, afferent mechanosensory neuron axons usually stopped within the lesion penumbra and failed to enter the core. Neutralizing mAbs, however, allow...Study shows our ancestors survived 'Snowball Earth'
... 2.3 billion years since Earth's atmosphere became infused with enough oxygen to support life as we know it. About the same time, the planet became encased in ice that some scientists speculate was more than a half-mile deep. That raises questions about whether complex life could have existed before "Snowbal...Findings by Einstein scientists reveal possible strategy against obesity, diabetes and infertility
...s a cell-permeable peptide (short protein) that we infused into specific areas of the hypothalamus using fine needles. This technique can serve as a model for investigating all types of signaling pathways in selective regions of the brain." The researchers found that STAT3 production is essential for lept...A single sugar found responsible for an antibody's ability to treat inflammation
...lupus, arthritis and asthma. And yet, when IVIG is infused into people with those exact autoimmune conditions, it calms inflammation rather than causes it. Jeffery Ravetch, Theresa and Eugene M. Lang Professor and head of Rockefeller's Laboratory of Molecular Genetics and Immunology, was struck by this in......n that in both activated cells in culture and rats infused with angiotensin II, CaMKII phosphorylates a serine residue of a1H T-type Ca2+ channels, which leads to an increase in the intracellular Ca2+ concentration. Blocking this phosphorylation step in rats decreased the amount of aldosterone produced in re......tive. In contrast, when the basal forebrain was infused with a nitric oxide "donor" an agent that boosts nitric oxide levels during a normal sleep-wake cycle, adenosine levels increased and the rats fell into a sleep much like the "recovery" sleep that occurs after prolonged wakefulness. Blocking adenos...