Preclinical study links gene to brain aneurysm formation
...xide synthase (NOS-3) or the plasminogen activator inhibitor (PAI-1). To determine whether absence of the genes resulted in an increased rate of aneurysm formation, researchers blocked one of the two carotid arteries that carry blood to the brain. They then examined brain artery samples for signs of aneurys...COX-2 inhibitors delay pancreatic cancer precursors in mice
...monstrate the effect of an anti-inflammatory COX-2 inhibitor on the development of pancreatic cancer. The stu...igh-risk for developing pancreatic cancer, a COX-2 inhibitor may offer some protection. In the future, Dr. Eibl and others plan to study the long-term effects...News tips from the Journal of Neuroscience
...al. show this week that G-substrate, an endogenous inhibitor of the serine/threonine phosphatases PP2A and PP1, may confer protection to A10 neurons. G-substrate got its name because it was first identified as a substrate for cGMP-dependent protein kinase. In rats and humans, A10 neurons expressed up to three ...New use for a cell toxin found to inhibit survival proteins in cancer cells
...r compound, 2-Methoxy antimycin, is the only Bcl-2 inhibitor reported with gain of function activity, which pro...strategy has already yielded one additional Bcl-xL inhibitor with "gain of function" activity, reported in the Molecular Cancer Therapeutics paper. Funding for t...Scientists follow familiar TRAIL to new cancer therapy
...e researchers also discovered that the multikinase inhibitor sorafenib prevented TRAIL-mediated induction of Mcl-1 and cIAP2, and although it had little effect on the killing of TRAIL-resistant cells when administered alone, combination with TRAIL caused significant death of previously TRAIL-resistant cancer c...Regulating alternative splicing during neural development
...midine-tract binding protein (PTB) is a well-known inhibitor of alternative splicing in various cell types. A neuronal version of PTB - called nPTB - is expressed solely in nerve cells, but its function has remained elusive. Dr. Black and colleagues now show that a switch in expression between PTB and nPTB ......thritis and diabetes. The team designed a specific inhibitor called ISO-1 to fit into this pro-inflammatory site. In an animal model of sepsis, ISO-1 abolishes MIFs potent inflammatory abilities and the animals respond dramatically. They lived through the once-fatal sepsis. In patients in the throes of seps...Frog molecule could provide drug treatment for brain tumors
...tions, ribonucleases are prevented from working by inhibitor molecules. But because Amphinase is an amphibian ribonuclease, it can evade the mammalian inhibitor molecules to attack the cancer cells. As a treatment, it is most likely to be injected into the ar...TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
... new light on the workings of the important cancer inhibitor topotecan. Little had been known about the underlying molecular mechanism, but the Delft scientists can now view the effects of the medicine live at the levelin of a single DNA molecule. The research is being published this week in the journal Natur...Alzheimer's drug based on Purdue -- designed inhibitor begins clinical trials
...irect CoMentis in the generation of beta-secretase inhibitor drugs. The treatment molecule, beta-secretase inhibitor CTS-21166, is the culmination of this work. "The molecule is both highly potent and highly selecti...New amfAR research grants to optimize HIV treatment
...alo Alto, CA $107,644 Immunologic benefits of CCR5 inhibitor intensification: The new antiretroviral maraviroc works by blocking the cell surface protein CCR5 and thus preventing the virus from entering cells. Dr. Shulman postulates that the drug might also prevent disease by reducing the activation state of t...Weill Cornell team identifies potential new cancer drug target
...ved in the NF-kappa B pathway called the "X-linked inhibitor of apoptosis" (XIAP). Scientists had already discovered that XIAP thwarts the apoptotic impulse by putting the brakes on key enzymes called caspases. XIAP is also known to be highly active in cancer cells, but it is found in relatively low levels in...Hepatitis B drug can compromise HIV treatment
...lly a very potent, but not particularly effective, inhibitor of HIV replication, he said. Altering the entecavir molecule to eliminate that plateau of effectiveness might well yield a new and effective anti-HIV drug, said Siliciano. Thus, he and his colleagues are further exploring the mechanism of the plate...LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
...c acid would affect inflammation, the team used an inhibitor to block retinoic acid in the mice. This led to the decrease of anti-inflammatory T cells, showing that reducing retinoic acid increased inflammation. In a third, particularly exciting approach, the scientists treated T cells with retinoic acid in ...News tips from the Journal of Neuroscience
...jection of either vehicle or the irreversible EGFR inhibitor PD168393 (4-[3(bromophenyl)-amino]-6-acrylamidoquinazoline) at the injury site. Treated rats showed greater and faster recovery in locomotion, sensory function, bladder control, and weight gain compared with control-treated rats. Drug-treated animals...U-M researchers discover gene switched off in cancer can be turned on
...me cancer cells. By exposing the BRM protein to an inhibitor drug, the researchers were able to turn the gene back on, allowing BRM to be expressed. The researchers found this gene is turned off in about 15 percent of tumors studied, including cells from lung, esophageal, ovarian, bladder, colon and breast can...Researchers shed light on mechanism of action used by anti-cancer drug
...ancer in adults. It was originally developed as an inhibitor of the oncogene, Raf, which is frequently mutated in numerous cancers, including leukemia. Oncogenes are typically responsible for promoting tumor growth. Previous findings by Grants team, reported in the Journal of Biologic Chemistry, showed that ...ChemGenex announces publication confirming activity of Ceflatonin in T315I-Positive CML
...evalent mutation in those who fail tyrosine kinase inhibitor therapy. The publication by Dr. Laurence Legros of the Hpital Archet, Nice, France and colleagues describes the treatment with Ceflatonin (homoharringtonine, HHT) of a Gleevec-resistant, chronic-phase CML patient with the T315I Bcr-Abl mutation. The ...Super fruit fly may lead to healthier humans
...California. First, it demonstrates that a single inhibitor can dramatically alterlifespan, a very complex trait. It is remarkable that you can alter it witha single genetic change. We dont really need to make fruit flies live longer, but if we understandhow to do this, our approach may have direct applicat......-term memory to be formed, Wood said. For the HDAC inhibitor to enhance memory, we need to administer the drug during this critical period when gene expression is required. The protein CBP must be present for HDAC inhibitors to improve memory, Wood and his colleagues discovered. Tested in mice genetically en...