A genetic 'gang of 4' drives spread of breast cancer
... treat advanced colorectal cancer. Celecoxib is an inhibitor of COX2 that is used as an anti-inflammatory, and is being tested in clinical trials against many types of cancer. The researchers also tested whether cetuximab and celecoxib would work effectively in concert to reduce metastasis in mice. "We found t...Tumors stopped from spreading to new sites
... development of lung metastases. Treatment with an inhibitor of TGF-beta blocked the increased lung metastases. Furthermore, mice whose tumors did not express the receptor for TGF-beta did not develop increased incidence of lung metastases after treatment with radiation, indicating that TGF-beta affects the ca...JCI table of contents -- April 5, 2007
... development of lung metastases. Treatment with an inhibitor of TGF-beta blocked the increased lung metastases....hereas ASM cells from mice expressing a G-alpha-i2 inhibitor contracted more. By contrast, overexpression of G-alpha-i2 decreased airway relaxation by beta-agoni...Glucose triggers brain cell death in rats after hypoglycemic coma
...n death were prevented when the rats were given an inhibitor of NADPH oxidase, indicating a key role for this enzyme. "It is well-established that mitochondria can be a source of oxidative stress," says Swanson. "But in this setting, oxidative stress comes from an entirely different source." He adds that t...JCI table of contents: April 2, 2007
...tion could be reversed by the administration of an inhibitor of the angiotensin II receptor into the brain. Furthermore, production of angiotensin II was specifically detected in the SFO and eliminating the expression of human angiotensinogen in the SFO reversed the increased water and salt consumption. This s...Natural mechanism for immune suppression paves way for cancer trials
... NCI has produced kilogram quantities of the IDO inhibitor compound and contracted with a series of labs to d...an move from the laboratory to humans. "The IDO inhibitor should result and that is why we need to do the trials because we dont know for sure until we do i...JCI table of contents: March 15, 2007
...sinki, Finland, have found that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL. In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pivi Ojala and colleagues show that Nutlin...Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity
...ation of the enzyme. Structural examination of the inhibitor complexes, which included the drug gefitinib (Ires... that mutations of the EGFR dramatically influence inhibitor binding and suggest that the different EGFR mutations present distinct targets for application and d...Study reveals how some molecules inhibit growth of lung cancer cells
...er understanding of the effect of the mutations on inhibitor binding at a structural level, it may be possible ...rsions of EGFR bound to several different types of inhibitor molecules. They found that two inhibitors the drug gefitinib (marketed as Iressa(R), and a compoun...News tips from the Journal of Neuroscience
...ase domain and thus can act as a dominant-negative inhibitor of TrkB signaling. The authors overexpressed a green fluorescent protein (GFP)TrkB1.T1 fusion protein in their favorite presynaptic cells, Xenopus laevis retinal ganglion cells (RGCs). GFPTrkB.T1 did not disrupt axon pathfinding to the tectum. Howeve...Green tea and COX-2 inhibitors combine to slow growth of prostate cancer
...in-Madison demonstrate that low doses of the COX-2 inhibitor celecoxib, administered with a green tea polypheno...cancer cells. Alone, both EGCG and NS-398, a COX-2 inhibitor similar to celecoxib, demonstrated the ability to slow cancer cell growth and limit the presence of ...Treatment extends survival in mouse model of spinal muscular atrophy
...cells and that treating pregnant mice with an HDAC inhibitor can increase the survival of their babies with SMA. Preliminary clinical trials are now underway to test several HDAC inhibitors in children who have SMA. However, the drugs in those clinical trials are weak HDAC inhibitors with other biological ef...European approval of HIV drug darunavir will provide a potent new option with Fuzeon
...risation in the European Union of the new protease inhibitor (PI) darunavir (boosted with ritonivir) provides physicians with the opportunity to build a potent new treatment combination with the fusion inhibitor, FUZEON. The combination of FUZEON and boosted darunavir has been shown to give treatment-experienc...JCI table of contents: February 15, 2006
EDITOR'S PICK: Protein inhibitor tangles with Alzheimer's disease Mayo Clinic researchers have now shown that a drug that inhibits the function of the protein Hsp90 reduces brain levels in mice of the protein tau, the abnormal accumulation of which has been implicated in the path...Cholera pathogen reveals how bacteria generate energy to live
...f them might be targeted by novel antibiotics. "An inhibitor or drug would be specific," she said. "You could kill the bacteria without doing anything to the human host." But Barquera believes that the most important benefits of her research could develop in ways that cannot be foreseen: "From the basic sci...Disabling key protein may give physicians time to treat pneumonic plague
...opefully someone will start the search soon for an inhibitor of PLA that is specific and non-toxic enough to be used as an adjunct treatment," Goldman says. "That might give us enough time to use antibiotics to save patients afflicted with pneumonic plague."Goldman hopes to conduct follow-up studies to learn m...Drug strategy makes cancer genes get lost in translation
.... They also found evidence that the small molecule inhibitor exhibits activity against multiple cancer cell lin...said. However, they cautioned, the newly described inhibitor is not strong enough for use as a drug in itself. The researchers will next work to chemically modif...Estrogen interferes with immune surveillance in breast cancer
... report that estrogen induces the expression of an inhibitor that blocks immune cells' ability to kill tumor ce...tes production of a granzyme inhibitor, proteinase inhibitor 9 (PI-9). The inhibitor binds the granzyme, preventing it from initiating the molecular cascade that...Researchers develop new strategy for the treatment of CML
...184352, another clinically relevant small molecule inhibitor of a critical cellular survival pathway that inactivates an important survival protein known as ERK1/2 (extracellular-signal regulating kinase1/2). The article was pre-published as a First Edition Paper in Blood, the journal of the American Society o......leagues solved the crystal structure of the DARPin inhibitor in complex with AcrB. They were able to confirm that the AcrB pump is split into three subunits, each of which exhibit distinctly different conformations. Each subunit has a differently shaped substrate transport channel; these variable channels pr...