New technique targets pesticide-resistant insects
...ck moth. The invention relies on the use of enzyme inhibitors such as piperonyl butoxide (PBO), a natural substance derived from sesame oil. Dr Gunning said previous efforts to use PBO failed, because the pesticide was inactivated by the insect's metabolic enzymes before the inhibitor had a chance to work. Dr ...UNC scientists identify sticky protein in sickle cell red blood cells
...use in diseases such as Crohn's disease, and these inhibitors are now attractive and rational therapies for sickle cell disease," said Parise. ...Anti-cholesterol drug treats Alzheimer's disease in mice
...hat slow-release biopolymer administration of ACAT inhibitors may be considered as a potential strategy for the treatment and prevention of Alzheimer's disease, alone or in combination with statins," they wrote. Birgit Hutter-Paier, Henri J. Huttunen, Luigi Puglielli, Christopher B. Eckman, Doo Yeon Kim, Alexan...Sniffing out the culprits of dust allergies
...responses or other disease processes and effective inhibitors that can be further developed for diagnostic or therapeutic research. Nicolas Winssinger, Robert Damoiseaux, David C. Tully, Bernhard H. Geierstanger, Keith Burdick, and Jennifer L. Harris: "PNA-Encoded Protease Substrate Microarrays" Jennifer Harr...Pushing the envelope to overcome HIV drug resistance
... resistance to currently prescribed HIV-1 protease inhibitors is devastating to patients and is surprising given the way these drugs work. Protease inhibitors are all small-molecule, competitive, active-site inhibitors--low molecular weight compounds that fit...Intracellular protein localization involved in new tumor progression pathway
...vivin is a member of a family of proteins that are inhibitors of apoptosis (IAPs), but the means by which survivin inhibits apoptosis remains largely unknown. Dario Altieri and colleagues, from the University of Massachusetts Medical School, investigated the where survivin is located within the cell to see whet...Antibiotic identified as potential anti-cancer candidate
...umor growth in mice can be suppressed by these Pdf inhibitors and suggest a mechanism of actinonin action. Taken together, these data have significant implications for the understanding and development of various Pdf-based therapeutic strategies for bacteria, mycobacteria, parasites, or cancer....Normal cells in tumors may aid cancer growth
... Loss of genes for such factors would remove those inhibitors and allow cancer cells to grow. "But those are only hypotheses," Eng says. "I think that the stroma plays an important role in enabling a tumor to invade neighboring tissue and spread. If that proves to be true, someone may someday develop a dr...Early life stress harms mental function and immune system in later years
... the effects of using selective serotonin reuptake inhibitors such as Prozac during early development on the emo...ems," says Richardson. Serotonin reuptake inhibitors (SSRI) such as Prozac are increasingly being used to treat psychiatric conditions in children and pr...Sandbagging cancer in the bloodstream
... of using a class of compounds known as Src kinase inhibitors to treat metastatic cancer in mice. Rather than co...ts showed that normal mice treated with Src kinase inhibitors also acquired a high degree of resistance to the metastasis of tumor cells. This suggests a possible...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...s by pharmaceutical companies to develop A peptide inhibitors -- mainly by screening for small molecules that wo...prevent neuronal cell death from toxic aggregates, inhibitors of aberrant molecular signaling pathways in Alzheimer's, and vaccines to trigger antibodies to rid t...Stress impairs thinking via mania-linked enzyme
...y problem is, namely in the PKC pathway. Since PKC inhibitors could act more directly, they might quench symptoms more quickly. Patients could carry PKC inhibitors and take them preventively, as soon as they sense a manic episode coming on." Clinical trials of a P...Elevated inflammatory enzyme, Lp-PLA2, significantly linked to ischemic stroke
...SmithKline (GSK) is actively investigating Lp-PLA2 inhibitors and the role they may play in further reducing the risk of stroke and coronary heart disease. Lp-PLA2 is an enzyme that helps process a form of low-density lipoprotein, or "bad," cholesterol (LDL-C) into products within atherosclerotic plaques and p...Drug may hinder recovery from heart attacks
Some new generation COX-2 inhibitors may not allow heart attack patients to recover fully, research indicates. Researchers at the University of Alberta have discovered a basic cellular process the body uses to balance pH in cells--also critical to recovery following a heart attack--is c...Researchers discover molecular timekeeper in bone development
...es, such as osteoporosis," he said. "In fact, HDAC inhibitors are currently being used for the treatment of cert...t will be interesting to investigate whether these inhibitors influence the process of bone formation." Other UT Southwestern contributors to this study include D...GlaxoSmithKline awards $250,000 in research grants for research on drug therapies for HIV/AIDS
...hird," Dr. Huang said. "The goal is to combine the inhibitors into a single, tri-active protein capable of block...ughput drug screening system to identify potential inhibitors of HIV transcription. "HIV gene expression is dependent on a unique viral protein, called HIV-1 tra...Other highlights in the November 17 JNCI
...colleagues show that pretreatment with proton pump inhibitors caused tumor cells resistant to cisplatin to become sensitive to the anticancer drugs. They suggest that this strategy may be useful for treating human solid tumors that are drug resistant or even for increasing the efficacy of antitumor drugs in dru...New protein structure may aid in design of therapeutics for autoimmune disease
...ly useful in the rational design of small molecule inhibitors of PKCΘ, which has been implicated in T-cell ...have the potential to aid in identifying selective inhibitors of kinase function that can act as therapeutics for diseases in which T cells are targeting native r...A new species of amyloid peptide
...ase. To date, more than one dozen γ-secretase inhibitors have been developed or identified."...Genetic defect confers risk of major depression, resistance to SSRI drug therapy
...nce to treatment with selective serotonin reuptake inhibitors (SSRIs), a class of drugs that includes paroxetine (Paxil TM ), sertraline (Zoloft TM ), and fluoxetine (Prozac TM ), the team found. In addition to its diagnostic use, the genetic marker might therefore also aid in identifying, in advance, those pat...