Researchers discover new gene in colon cancer
...ors, have a lower incidence of colon cancer. COX-2 inhibitors have been shown to shrink the size of tumors in mice. Markowitz likens the 15-PGDH gene to a naturally occurring COX-2 inhibitor. (Celebrex, a popular arthritis drug, is also a COX-2 inhibitor.) Markowitz found that 15-PGDH is directly controlled a...Mutant gene linked to treatment-resistant depression
...hich often respond to serotonin selective reuptake inhibitors (SSRIs) antidepressants that block the re-absorption of serotonin, enhancing its availability to neurons. In the current study, a similar variant culled from human subjects produced 80 percent less serotonin in cell cultures than the common vers...JCI table of contents, December 15 2004
...rmal platelet function. Platelet-specific integrin inhibitors like Integrilin fall into this category. The study...ci.org/cgi/content/full/114/12/1693 . Caspase-3 inhibitors accelerate osteoporosis When our cells reach a certain age or state of cell health they undergo a ...Timing is everything for optimum combined cancer therapy
...wever, results of early clinical trials with these inhibitors have not yet exhibited the same success observed in animal models. Now, a new study published in the December issue of Cancer Cell demonstrates that a unique time period exists during which combined radiation and antiangiogenic therapy can exert a re...Growth of common skin cancer blocked in gene-switch mice
...nt given the current efforts to develop Hh pathway inhibitors as a means of combating human BCCs as well as other cancers. In contrast to other cancer models where inhibition of Hh signaling leads to durable tumor regression, Dr. Dlugosz's new work raises the possibility that Hh pathway inhibition in BCCs, whi...A key signaling molecule in osteoarthritis is identified
... of osteoarthritis." Dr. Li's results suggest that inhibitors of DDR2 signaling may be useful as drugs to slow down osteoarthritis progression. This comes as good news in the wake of several drugs used to treat arthritic pain being linked to severe side effects....Genetic polymorphisms, antidepressant use may be associated with altered tamoxifen activity
...ntidepressants called selective serotonin reuptake inhibitors (SSRIs) may be associated with altered tamoxifen a...ic variants and careful attention to use of CYP2D6 inhibitors may help identify a group of women who may experience greater benefit from tamoxifen and/or who migh...EB and IUPS - Where cures of tomorrow can be seen in the science of today
...ious diseases, neoplasia and angiogenesis; protein inhibitors in drug design; and gene and protein networks and medicine. Eight award lectures by leading experts include topics such as orphan nuclear receptors, lipid-protein interactions, and enzymes in the biosynthesis and tailoring of peptide natural products...Celebrex prevents adhesions after surgery
...Program at Children's Hospital Boston tested COX-2 inhibitors in an animal model of abdominal adhesion formation...gery, groups of 6 to 18 mice received either COX-2 inhibitors (Celebrex or Vioxx), non-selective COX inhibitors (such as ibuprofen and aspirin) or placebo for 10 ...Protein stops growth of brain tumor, OHSU study shows
...ave developed to confer resistance to the class of inhibitors that blocks the extracellular domain" on the glioblastoma cells. About a third of all glioblastomas derive from the mutant receptor, Neuwelt said. Although herstatin is not effective against the mutant EGF receptor, the study's results demonstrate hi...... The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice. In an accompanying commentary, Anthony Fauci and Mark Challberg from the National Institutes of Health point out that this approach "may serve to turn...Blocking cell signaling can stymie viral infections, study shows
...School. These findings open the way for developing inhibitors of other pathways in cells used by different viruses as well. In a commentary appearing in the same issue of the Journal of Clinical Investigation, Anthony S. Fauci, MD, director of NIAID, and Mark D. Challberg, PhD, emerging viral diseases program o...Stopping smallpox in its tracks: A new anti-viral approach
... The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice. In an accompanying commentary, Anthony Fauci and Mark Challberg from the National Institutes of Health point out that this approach "may serve to turn...Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study
...atients may also act as weak and nonspecific NF-kB inhibitors in addition to having many other activities. Give...tudy, drugs that are more potent and more specific inhibitors of NF-kB also need to be tested for their therapeutic effects on Crohn's disease patients. Karin, w...JCI Table of Contents, March 1, 2005
...on of harmful cells. Thus, administration of MMP inhibitors may be potentially useful for patients at risk of cardiac rupture after MI. TITLE: Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice AUTHOR CONTACT:Yasunori Okada Keio Univeris...Mouse model of leukemia yields exciting therapeutic implications for rare childhood cancer
...verning cell survival and proliferation. Specific inhibitors of Ras/Mek and Tor pathways interfered with mutant...l trials of currently available Ras/Mek and/or Tor inhibitors should be considered; at least until selective Shp2 inhibitors are developed. Our mouse model of Shp...New drug may be formidable adversary for hard to treat leukemia
...bility of novel, high potency, Abl tyrosine kinase inhibitors will usher in a new generation of clinical studies that may result in additional major advances in the therapy of hard to treat leukemia....Studies reveal methods viruses use to sidestep immune system
...o try to limit infection." Drugs called protease inhibitors currently are used to treat patients infected with... could help toward further developing the protease inhibitors and more effective therapies for hepatitis C and possibly other viral infections." A third paper, a...Study shows naturally occurring proteins protect against rapid tumor growth
...umstatin, endostatin and thrombospondin-1, natural inhibitors of angiogenesis found in blood, urine and tissues ...growth. Their results showed when any one of these inhibitors was removed from the mice, tumors grew at a rate two to three times faster when compared with normal......o or three new buds. When lungs were treated with inhibitors of the Rho pathway, lung bud formation was reduced by more than half when examined 48 hours later. When treated with agents that activate Rho and promote cytoskeletal contraction, budding increased. The agents had similar effects on the growth and de...