Tag: "inhibits" at biology news

Penn researchers discover how key protein stops inflammation

...aled that Bcl-3 interacts with p50, a protein that inhibits gene transcription by binding to DNA. p50 turns off the DNA region coding for inflammation, halting the response to infection, explains Chen. Without Bcl-3, Chen says p50 cannot stop the inflammation response, but instead will become degraded very ...

Discovery in plant virus may help prevent HIV and similar viruses

...rchers is how blocking the function of one protein inhibits transcription and replication of the viruses. Discovering the answer could mean major advances for prevention of retroviruses and treatment of the diseases they cause in plants and animals....

A new brake on cellular energy production discovered

... new mitochondrial factor, MTERF3. This new factor inhibits the expression of mtDNA and can thus slow down the cell's energy production. The discovery, which is published in the journal Cell, may in future lead to completely new ways of treating various diseases. Impaired mitochondrial function gives rise ...

JCI table of contents: July 19, 2007

...g imatinib mesylate (also known as Gleevec), which inhibits the PDGF-BB receptor, and this resulted in reduced pericyte content and increased tumor growth compared to tumors left untreated. They believe that these effects are due to an increased number of pericytes in the tumor, which can actually limit tumor...

Piecing together the cyanobacteria puzzle

...ation during photosynthesis produces oxygen, which inhibits nitrogen fixation. Different species of blue green algae solve the problem in different ways and scientists still dont understand how some of the most important species can get both of these jobs done. To develop the new method, the researchers ...

New research shows vaginal bacteria vary among healthy women, need customized treatment

...y. The environment maintains a low pH balance that inhibits the growth of pathogens. The vagina is elegant in its simplicity, he said. A healthy vagina maintains itself and is able to self-correct when minor imbalances occur. When conditions in the vagina change the pH balance dramatically, harmful bacteri...

A compound from olive-pomace oil gets 80 percent slowing down of HIV spread

... extracted from dry olive-pomace oil in oil mills inhibits serin-protease, an enzyme used by HIV to release itself from the infected cell into the extracellular environment and, consequently, to spread the infection into the whole body. These scientists from Granada determined that the use of olive-pomace oi...

Elevated CO2 in atmosphere weakens defenses of soybeans to herbivores

...by soybeans when they are under insect attack. It inhibits further attack once the invader has ingested it. Our results suggest that elevated CO2 increased the susceptibility of soybean to invasive insects by down-regulating the expression of hormones related with defense, which down-regulate the importa...

Researchers discover method for identifying how cancer evades the immune system

...-production of B7-H4, a gene whose protein product inhibits immune activation. The human colorectal cancers, however, showed variations in their immune signatures, which researchers saw as an indication of the need to understand the signature for each patients individual cancer. I see it as the beginning s...

MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation

...g findings because the expression of the gene that inhibits PAK occurs in the third week after birth, which means that the neuronal abnormalities in the fragile X mouse are reversed after they appear," said Eric Klann, a professor at New York University's Center for Neural Science. "This is very exciting beca...

Alzheimer's drug based on Purdue -- designed inhibitor begins clinical trials

...built a molecule that binds to this key enzyme and inhibits its activity, a beta-secretase inhibitor. "These molecules fit together like puzzle pieces," Ghosh said. "We created a molecule that fits with a key piece of the Alzheimer's disease puzzle. When the treatment molecule binds to the enzyme, it change...

Weill Cornell team identifies potential new cancer drug target

...n relatively low levels in healthy cells. How XIAP inhibits caspases is known, but how XIAP induces NF-kappa B activation is entirely unclear. "We wondered if we could find out how XIAP induces the NF-kappa B pathway," explains lead researcher Dr. Miao Lu, a postdoctoral fellow of biochemistry at Weill Corn...

Autism-related proteins control nerve excitability, researchers find

...s the excitability of nerve cells, while the other inhibits cell activity. Most importantly, these effects dep...e second cell, while at other synapses, the signal inhibits the second cell. Infants are born with far more synapses, both excitatory and inhibitory, than ad...

Hepatitis B drug can compromise HIV treatment

...sting part of this study was that, while entecavir inhibits HIV infection at a very low concentrationmeaning that it has a very high affinity for reverse transcriptase, much better than the drugs that we currently useit is actually not a very good HIV drug. The inhibition doesn't increase with dosage; it just...

News tips from the Journal of Neuroscience

... has at least two distinct molecular functions: it inhibits Ras activity via a GTPase-activating protein (GAP)-related domain (GRD), and it regulates cAMP by activation of adenylyl cyclase. This week, Ho et al. asked how loss of these functions affected learning and memory in flies. In a pavlovian olfactory c...

Cytokine resistance contributes to pathology of type 2 diabetes

...tion of other anti-inflammatory cytokines. It also inhibits secretion of the pro-inflammatory cytokines. When IL-4 binds to its receptor on a target cell, it sets off one of two cascades of intracellular events. The first of these signal transduction pathways, the Jak-STAT pathway, is well studied and wel...

Other highlights in JNCI, June 12

...ston, and colleagues investigated whether deguelin inhibits the function of Hsp90. Mice with transplanted huma...s showed that deguelin directly binds to Hsp90 and inhibits its functional activity, which results in a reduction in the expression of its client proteins. Addi...

Researchers shed light on mechanism of action used by anti-cancer drug

...earchers identified a mechanism by which sorafenib inhibits protein translation, and which may be involved in reducing expression of pro-survival factors, such as Mcl-1, and other proteins. The findings were published online in the journal Molecular and Cellular Biology on June 4. According to Grant, sorafe...

Talcum powder stunts growth of lung tumors

...d by the presence of talc to produce a factor that inhibits the growth of blood vessels and kills the tumor ce...using the normal cells to produce this factor that inhibits the growth of the tumor. The antitumor effects of talc appear to be long-lasting, said Antony, who...

Every moment counts: Predicting treatment responses earlier for brain tumor patients

...drug bevacizumab is an antiangiogenic agent, which inhibits the development of blood vessels that supply blood and oxygen that contribute to a tumor's growth, said Chen. "Until this study, there were no reliable predictors of therapeutic response for patients with primary brain tumors undergoing treatment wit...

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