Doernbecher Children's Hospital scientist earns coveted Javits award
...orkin the cellular and molecular cause(s) of brain injury in prematureinfants. NINDS is a branch of the Nati...chanisms responsible for causing whitematter brain injury in developing infants. White matter brain injury isthe underlying basis for cerebral palsy, or CP, a...Testosterone replacement therapy: How safe for aging men?
...e supplementation of aging male SHR promotes renal injury and thereby exacerbates hypertension. The results ...hs) prevents the development of hypertensive renal injury without altering existing hypertension levels. The Big Picture The study is part of the research...Sugar and spice and everything nice: Health differences in newborn girls and boys
...um) to ischemia may increase its susceptibility to injury during ischemia and offer a potential explanation for the poorer clinical outcomes found in infant females following cardiac surgery. Study 2: Lower Success Rates When Using Female Newborn Liver Donors As many as 500 children undergo liver tran...News tips from the Journal of Neuroscience
...row in on genes affected in three peripheral nerve injury models of neuropathic pain. The most highly regula...ulated in the dorsal horn of the spinal cord after injury and were expressed only in microglia. The complement cascade culminates in C5 and C5a receptor (C5aR...New mechanism links smoking to lung damage
...and NAD, to leak out, leading, ultimately, to cell injury and death. Drugs that prevented hemichannels from opening protected the cells from similar exposures. Treating the cells with silencing RNA for the hemichannel protein also protected cells by preventing the creation of these channels. "It require...Cell damage caused by brushing may help keep gums healthy
...nd blood vessels leak out of injured cells. Cell injury also turns on expression of the c-fos gene, an early-response gene often activated under stress that may be the first step in a response such as cell division or growth, says Dr. Paul L. McNeil, MCG cell biologist and corresponding author. Its very...Nature's weapon against nerve agents
...rve agents or as a result of other forms of brain injury including stroke or disease they release far more...revent much of the brain damage caused after brain injury in rats. It appears that most of the damage that is caused is due to excess glutamate since we can e...JCI table of contents -- July 26, 2007
...r understanding of tissue damage after spinal cord injury Acute spinal cord injury can damage spinal cord tissue and result in loss of functions such as mobility or feeling. In a stud...Air pollution link to clogged arteries
... airborne pollutant particles cause cardiovascular injury is poorly understood. But it is known that these particles are generally coated with a number of chemicals such as organic hydrocarbons, transition metals, sulfates and nitrates. Organic hydrocarbons and transition metals inflame airways by generatin...UCLA study links air pollution to clogged arteries
... Exactly how air pollutants cause cardiovascular injury is poorly understood, Nel said. But we do know that these particles are coated with chemicals that damage tissue and cause inflammation of the nose and lungs. Vascular inflammation in turn leads to cholesterol deposits and clogged arteries, which can...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...to human injury, reveals that treatment soon after injury combining radiation therapy to destroy harmful cel...cure for human spinal cord injury. Treatment after injury is largely limited to steroids administered to prevent further deterioration. This research opens th...News tips from the Journal of Neuroscience
... Markelonis, and Tae H. Oh Traumatic spinal cord injury (SCI) leads not only to neuronal loss, but also to...hin receptor (p75NTR). Five days after a contusion injury at T10/11 in adult rats, the spinal cord showed elevated levels of proNGF (nerve growth factor). Pho...Accident-prone? Scientists link brain function to knee injuries
...lication for neurocognitive testing in the area of injury prevention, Swanik noted. It's hard to say at this...al for each individual to maximize performance and injury avoidance, but future studies will have to determine the relationship between our results and anxiet...Serica scientists win AOSSM Award for ACL (knee) tissue regeneration in preclinical study
...mmonly injured knee ligament, and is a very common injury among athletes. Female athletes are known to have a higher risk of injuring their ACL. Currently, 200,000 surgeries are performed each year in the U.S. to repair a torn or damaged ACL....JCI table of contents: July 12, 2007
...ed, platelets cluster together to plug the site of injury in the form of a blood clot (thrombus). In arterial disease, altered platelet aggregation can block blood vessels and cause heart attack or stroke. Platelet aggregation involves the binding of many molecules to platelet integrin alpha-IIb beta 3, and...Fat horses face health problems
... with the disorder as a result of his catastrophic injury at the 2006 Preakness. When that bond fails, and the hoof and bone start to fall apart, it is extremely painful to the horse, he continued. Laminitis is one of the most devastating and debilitating problems that we see with the horse. Funded in p...University of Cincinnati receives $1.7M to research molecular treatment of brain injury
...rch that could lead to better treatments for brain injury patients. Kenneth Strauss, PhD, will study two t...to harmful inflammation. COX-2 increases following injury and, to the brains detriment, remains elevated for many days. Strauss had originally been studyin...News tips from the Journal of Neuroscience
...n that pre-exposure or conditioning to a sublethal injury protects brain tissue against subsequent ischemia. If the phenomenon were better understood, it might be harnessed to treat stroke. Kunz et al. show this week that neuroprotection is twopronged, affecting the cerebral microvasculature as well as neur...Faulty cell membrane repair causes heart disease
...found that exercise exaggerated the stress-induced injury in these mice, suggesting that inadequate membrane repair led to cardiomyopathy. The research team also bred mice that lacked both dysferlin and the protein dystrophin, which is missing in patients with Duchenne muscular dystrophy. These "double kn......cts the heart from stress-induced left ventricular injury AUTHOR CONTACT: Kevin P. Campbell University of Iowa, Iowa City, Iowa, USA. Phone: (319) 335-7867 or (319) 335-6978; Fax: (319) 335-6957; E-mail: kevin-campbell@uiowa.edu View the PDF of this article at: https://www.the-jci.org/article.p...